Results 71 to 80 of about 432,257 (295)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

The genome sequence of the Bird-cherry Ermine moth, Yponomeuta evonymella (Linnaeus, 1758) [version 2; peer review: 2 approved, 1 approved with reservations]

open access: yesWellcome Open Research
We present a genome assembly from an individual female Yponomeuta evonymella (the Bird-cherry Ermine; Arthropoda; Insecta; Lepidoptera; Yponomeutidae). The genome sequence has a total length of 572.70 megabases. Most of the assembly is scaffolded into 32
Douglas Boyes, Callum Murray
doaj   +1 more source

Wall-thickness reduction of AP1000 primary coolant pipes subjected to cold roll-forming

open access: yes工程科学学报, 2016
A modified Johnson-Cook model was proposed based on the true stress-strain data of 316LN stainless steel and it was successfully used to describe the deformation characteristic of the steel at room temperature and low strain rate.
WANG Peng   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Laboratory Testing of FBGs for Pipeline Monitoring

open access: yesSensors, 2020
The monitoring of the effects of geohazards on pipelines can be addressed by optical fiber Bragg gratings (FBGs). They are sensitive to strain and bending, and are installed on the external surface of pipelines at discrete locations.
Andrea Carlino, Alberto Godio
doaj   +1 more source

Predicting computational reproducibility of data analysis pipelines in large population studies using collaborative filtering

open access: yes, 2018
Evaluating the computational reproducibility of data analysis pipelines has become a critical issue. It is, however, a cumbersome process for analyses that involve data from large populations of subjects, due to their computational and storage ...
Barghi, Soudabeh   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

PREDICTION OF THE GROUNDS TEMPERATURE BEHAVIOR OF THE SURFACE LAYING PIPELINE SUPPORT FOUNDATIONS FOR ENSURING THE TROUBLE-FREE OPERATION OF THE PIPELINE SYSTEM «ZAPOLYARIE — NPS PURPE»

open access: yesИзвестия высших учебных заведений: Нефть и газ, 2014
The problems of modeling of thermal interaction of the pipeline support pile foundation with the permafrost ground are considered. The article provides technical solutions for maintenance of the frozen condition of the grounds of pile foundations and ...
V. V. Pavlov   +3 more
doaj  

The anaesthesia gas supply system

open access: yesIndian Journal of Anaesthesia, 2013
The anaesthesia gas supply system is designed to provide a safe, cost-effective and convenient system for the delivery of medical gases at the point of-use. The doctrine of the anaesthesia gas supply system is based on four essential principles: Identity,
Sabyasachi Das   +2 more
doaj   +1 more source

Application of fiber optics in water distribution networks for leak detection and localization: a mixed methodology-based review

open access: yesH2Open Journal, 2021
This study reviews the state-of-the-art application of fiber optics in water distribution networks for leak detection and localization. The use of fiber optics in the oil and gas sector has been well established; however, its potential in water pipelines
Kabir Ibrahim   +3 more
doaj   +1 more source

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