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Investigation of reproductive toxicity of piperaquine in mice
Reproductive Toxicology, 2010Reproductive toxicity data for the antimalarial drug piperaquine (PQ) were obtained in pregnant mice (F(0)) and their offspring (F(1) and F(2)). PQ phosphate (0-300 mg/kg/day) was given to pregnant Swiss mice from gestational days 14-18. Two F(1) pups from each litter (one male and one female) proceeded to maturity and were mated within dose groups ...
Batty, KT +9 more
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Chinese Journal of Integrative Medicine, 2009
The study aimed to evaluate and compare the efficacy and safety of dihydroartemisinin-piperaquine phosphate (Artekin) and artemisinin-piperaquine (Artequick) in the treatment of uncomplicated falciparum malaria.A total of 103 uncomplicated falciparum malaria patients were enrolled and randomly assigned to two groups: 52 cases in the Artequick group ...
Trieu Nguyen, Trung +3 more
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The study aimed to evaluate and compare the efficacy and safety of dihydroartemisinin-piperaquine phosphate (Artekin) and artemisinin-piperaquine (Artequick) in the treatment of uncomplicated falciparum malaria.A total of 103 uncomplicated falciparum malaria patients were enrolled and randomly assigned to two groups: 52 cases in the Artequick group ...
Trieu Nguyen, Trung +3 more
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Dihydroartemisinin–Piperaquine Failure in Cambodia
New England Journal of Medicine, 2014This letter suggests that rising treatment failures and parasite clearance times and decreasing piperaquine sensitivity 3 years after widespread introduction of artemisinin–piperaquine indicate rapidly emerging resistance to both artemisinin and piperaquine.
David L. Saunders +2 more
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A Comprehensive Review on the Pharmacokinetics and Bioanalysis of Piperaquine
Current Drug MetabolismPiperaquine is an important partner drug in artemisinin-based combination therapy, which is highly effective for the treatment of uncomplicated malaria. Several studies have been reported on its pharmacokinetic profiles in different populations, as well as its bioanalytical methods.
Yuewu, Xie +5 more
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Artenimol + piperaquine. Very slow piperaquine elimination: cardiovascular risks and interactions.
Prescrire international, 2014For the treatment of uncomplicated Plasmodium falciparum malaria, drug combinations based on artemisinin derivatives (such as artemether + lumefantrine in France) are an alternative to atovaquone + proguanil, especially when there is a high risk of resistance to drugs commonly used for malaria prevention.
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