Artemisinin resistance and malaria elimination: Where are we now? [PDF]
Frontiers in Pharmacology, 2022 The emergence of artemisinin resistance is a major obstacle to the global malaria eradication/elimination programs. Artemisinin is a very fast-acting antimalarial drug and is the most important drug in the treatment of severe and uncomplicated malaria ...
Borimas Hanboonkunupakarn +9 more
doaj +5 more sources
Antimalarial Mechanisms and Resistance Status of Artemisinin and Its Derivatives
Tropical Medicine and Infectious DiseaseArtemisinin is an endoperoxide sesquiterpene lactone isolated from Artemisia annua and is often used to treat malaria. Artemisinin’s peroxide bridge is the key structure behind its antimalarial action.
Dan Zheng +5 more
doaj +5 more sources
K13, the Cytostome, and Artemisinin Resistance [PDF]
Trends in Parasitology, 2020 Artemisinins - the frontline antimalarial drug class - are compromised by emerging resistance, putting at risk the lives of hundreds of thousands of people each year. Resistance is associated with mutations in a malaria parasite protein, called Kelch 13 (
Stanley Xie +2 more
exaly +4 more sources
Machine learning for artemisinin resistance in malaria treatment across in vivo-in vitro platforms [PDF]
iScience, 2022 Summary: Drug resistance has been rapidly evolving with regard to the first-line malaria treatment, artemisinin-based combination therapies. It has been an open question whether predictive models for this drug resistance status can be generalized across ...
Hanrui Zhang +3 more
doaj +3 more sources
Molecular markers of artemisinin resistance during falciparum malaria elimination in Eastern Myanmar [PDF]
Malaria JournalBackground Artemisinin resistance in Plasmodium falciparum threatens global malaria elimination efforts. To contain and then eliminate artemisinin resistance in Eastern Myanmar a network of community-based malaria posts was instituted and targeted mass ...
Aung Myint Thu +21 more
doaj +4 more sources
Escalating <i>Plasmodium falciparum K13</i> marker prevalence indicative of artemisinin resistance in southern Rwanda. [PDF]
Antimicrob Agents Chemother, 2023 In 2023, we updated data collected since 2010 on Plasmodium falciparum K13 and MDR1 drug resistance markers in Huye district, southern Rwanda. Artemisinin resistance-associated PfK13 markers occurred in 17.5% of 212 malaria patients (561H, 9.0%; 675V, 5 ...
van Loon W +9 more
europepmc +2 more sources
Molecular insights into artemisinin resistance in Plasmodium falciparum: An updated review
Infection, Genetics and Evolution, 2023 Malaria still poses a major burden on human health around the world, especially in endemic areas. Plasmodium resistance to several antimalarial drugs has been one of the major hindrances in control of malaria.
Yenny Djuardi, I Made Artika
exaly +2 more sources
Screening for K13-Propeller Mutations Associated with Artemisinin Resistance in Plasmodium falciparum in Yambio County (Western Equatoria State, South Sudan). [PDF]
Am J Trop Med Hyg, 2023 . Artemisinin-combined treatments are the recommended first-line treatment of Plasmodium falciparum malaria, but they are being threatened by emerging artemisinin resistance.
Molina-de la Fuente I +11 more
europepmc +2 more sources
Scientific Reports, 2021 Plasmodium falciparum has evolved resistance to almost all front-line drugs including artemisinin, which threatens malaria control and elimination strategies.
Mukul Rawat +5 more
doaj +2 more sources
Slowing artemisinin resistance in Africa. [PDF]
Sci AdvDiversifying antimalarial drug use across Africa offers the most immediate strategy to slow antimalarial resistance and limit potential increases in treatment failure rates.
Boni MF +4 more
europepmc +3 more sources