Results 41 to 50 of about 5,742,584 (242)

Molecular monitoring of Plasmodium falciparum resistance to artemisinin in Tanzania. [PDF]

, 2006
Artemisinin-based combination therapies (ACTs) are recommended for use against uncomplicated malaria in areas of multi-drug resistant malaria, such as sub-Saharan Africa.
Mugittu, Kefas, Beck, Hans Peter, Mugittu Kefas, Hassan Mshinda, Hans Beck, Mshinda Hassan, Blaise Genton, Kefas Mugittu, Genton Blaise, Beck Hans, Mshinda, Hassan, Genton, Blaise   +11 more
core   +1 more source

Artemisinin antimalarials: preserving the "magic bullet" [PDF]

, 2010
The artemisinins are the most effective antimalarial drugs known. They possess a remarkably wide therapeutic index. These agents have been used in traditional Chinese herbal medicine for more then 2,000 years but were not subjected to scientific scrutiny
White, Lisa, Maude, Richard J., Maude, RJ, Richard J. Maude, White, LJ, Woodrow, CJ, White, Lisa J., Charles J. Woodrow, Lisa J. White, Woodrow, Charles J.   +9 more
core   +1 more source

Epidrugs as Promising Tools to Eliminate Plasmodium falciparum Artemisinin-Resistant and Quiescent Parasites

Pharmaceutics, 2023
The use of artemisinin and its derivatives has helped reduce the burden of malaria caused by Plasmodium falciparum. However, artemisinin-resistant parasites are able, in the presence of artemisinins, to stop their cell cycles.
Thibaud Reyser, Lucie Paloque, Michel Nguyen, Jean-Michel Augereau, Matthew John Fuchter, Marie Lopez, Paola B. Arimondo, Storm Hassell-Hart, John Spencer, Luisa Di Stefano, Françoise Benoit-Vical   +10 more
doaj   +1 more source

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

New England Journal of Medicine, 2014
BACKGROUND Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria.
Elizabeth A. Ashley, M. Dhorda, Rick M. Fairhurst, Chanaki Amaratunga, P. Lim, Seila Suon, Sokunthea Sreng, Jennifer M. Anderson, S. Mao, Baramey Sam, Chantha Sopha, Char Meng Chuor, C. Nguon, S. Sovannaroth, S. Pukrittayakamee, P. Jittamala, K. Chotivanich, K. Chutasmit, C. Suchatsoonthorn, R. Runcharoen, H. Tran, Thuy-Nhien Nguyen, Thanh Viet Ngo, P. H. Nguyen, Y. Htut, K. Han, K. H. Aye, O. Mokuolu, Rasaq R. Olaosebikan, O. Folaranmi, M. Mayxay, Maniphone Khanthavong, B. Hongvanthong, P. Newton, M. Onyamboko, Caterina I. Fanello, A. Tshefu, N. Mishra, N. Valecha, A. P. Phyo, F. Nosten, P. Yi, R. Tripura, S. Borrmann, Mahfudh Bashraheil, J. Peshu, M. Faiz, A. Ghose, M. Hossain, Rasheda Samad, M. Rahman, M. Hasan, Akhterul Islam, Olivo Miotto, R. Amato, B. MacInnis, J. Stalker, D. Kwiatkowski, Zbynek Bozdech, Atthanee Jeeyapant, Phaik Yeong Cheah, Tharisara Sakulthaew, Jeremy Chalk, B. Intharabut, K. Silamut, Sue J. Lee, Benchawan Vihokhern, Chanon Kunasol, M. Imwong, J. Tarning, W. R. Taylor, S. Yeung, C. Woodrow, J. Flegg, D. Das, Jeffery L. Smith, M. Venkatesan, C. Plowe, K. Stepniewska, P. Guérin, A. Dondorp, N. Day, Nicholas J. White   +82 more
semanticscholar   +1 more source

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

eLife, 2021
The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium falciparum malaria parasites has led to widespread treatment failures across Southeast Asia.
Barbara H. Stokes, S. K. Dhingra, Kelly Rubiano, Sachel Mok, J. Straimer, Nina F. Gnädig, Ioanna Deni, Kyra A. Schindler, Jade R. Bath, Kurt E. Ward, Josefine Striepen, Tomas Yeo, Leila S Ross, E. Legrand, F. Ariey, C. Cunningham, I. M. Souleymane, A. Gansane, R. Nzoumbou-Boko, Claudette Ndayikunda, A. Kabanywanyi, A. Uwimana, S. Smith, Olimatou Kolley, M. Ndounga, M. Warsame, R. Leang, F. Nosten, T. Anderson, Philip J. Rosenthal, D. Ménard, D. Fidock   +31 more
semanticscholar   +1 more source

Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria : a literature review and meta-analysis of individual patient data [PDF]

, 2015
Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong sub-region and poses a major global public health threat. Slow parasite clearance is a key clinical manifestation of reduced susceptibility to artemisinin.
Wwarn Artemisinin based Combination Therapy Africa Baseline Stud,
core   +1 more source

Pre-existing partner-drug resistance to artemisinin combination therapies facilitates the emergence and spread of artemisinin resistance: a consensus modelling study

The Lancet Microbe, 2022
Summary Background Artemisinin-resistant genotypes of Plasmodium falciparum have now emerged a minimum of six times on three continents despite recommendations that all artemisinins be deployed as artemisinin combination therapies (ACTs).
O. Watson, B. Gao, Tran Dang Nguyen, T. N. Tran, M. Penny, David L Smith, L. Okell, R. Águas, M. F. Boni   +8 more
semanticscholar   +1 more source

The Threat of Artemisinin-Resistant Malaria [PDF]

New England Journal of Medicine, 2011
Since the 1970s, when Chinese researchers demonstrated the artemisinins' antimalarial potency, artemisinin-based combination therapy has become key to malaria control. But reduced susceptibility of Plasmodium falciparum to artemisinin is now being seen in some places.
Dondorp, A, Fairhurst, R, Slutsker, L, Macarthur, JR, Breman, J, Guerin, P, Wellems, T, Ringwald, P, Newman, R, Plowe, C   +9 more
openaire   +2 more sources

Molecular surveillance of Plasmodium falciparum drug-resistance markers in Vietnam using multiplex amplicon sequencing (2000–2016)

Scientific Reports, 2023
Emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapies (ACT) is a major challenge for Greater Mekong Subregion countries in their goal to eliminate malaria by 2030. Tools to efficiently monitor drug resistance
Eduard Rovira-Vallbona, Johanna Helena Kattenberg, Nguyen Van Hong, Pieter Guetens, Hideo Imamura, Pieter Monsieurs, Driss Chiheb, Annette Erhart, Bui Quang Phuc, Nguyen Xuan Xa, Anna Rosanas-Urgell   +10 more
doaj   +1 more source

Compensating P. falciparum artemisinin resistance [PDF]

Cell Host & Microbe, 2021
Amino acid deprivation from reduced hemoglobin degradation in Pfkelch13 artemisinin-resistant parasites reduces fitness. In this issue of Cell Host & Microbe, Mesén-Ramírez et al. decipher the role of nutrient permeable channel activity within the parasitophorous vacuolar membrane to compensate for this fitness cost in asexual blood-stage Plasmodium ...
Platon, Lucien, Cao, Jun, Menard, Didier
openaire   +3 more sources