Results 61 to 70 of about 5,742,584 (242)

Putting the genie back in the bottle? Availability and presentation of oral artemisinin compounds at retail pharmacies in urban Dar-es-Salaam. [PDF]

, 2006
BACKGROUND\ud \ud Recently global health advocates have called for the introduction of artemisinin-containing antimalarial combination therapies to help curb the impact of drug-resistant malaria in Africa.
Catherine Goodman, Black, Carolyn, Carolyn Black, Goodman, Catherine, Abdulla, Salim, Kachur, S Patrick, Salim Abdulla, S Patrick Kachur   +7 more
core   +1 more source

Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That Is Reversed by Proteasome Inhibition

mBio, 2020
The recent emergence of Plasmodium falciparum parasite resistance to the first line antimalarial drug artemisinin is of particular concern. Artemisinin resistance is primarily driven by mutations in the P.
Nelson V. Simwela, Barbara H. Stokes, Dana Aghabi, Matt Bogyo, David A. Fidock, Andrew P. Waters   +5 more
doaj   +1 more source

Artemisinins [PDF]

, 2005
Artemisinins were discovered to be highly effective antimalarial drugs shortly after the isolation of the parent artemisinin in 1971 in China. These compounds combine potent, rapid antimalarial activity with a wide therapeutic index and an absence of ...
C J Woodrow, S Krishna, Woodrow, C. J., Haynes, R. K., Woodrow, CJ, Krishna, S., Haynes, RK, Krishna, S, R K Haynes   +8 more
core   +1 more source

Artemisinin resistance: Cause for worry?

Journal of Marine Medical Society, 2019
Background: Artemisinin resistance is being reported from certain regions of the world. Globally, the scientific community is engaged in tracing the epidemiology of this resistance while also working on possible interventions to curb the spread.
Anurag Khera, Reema Mukherjee
doaj   +1 more source

Evidence of Artemisinin-Resistant Malaria in Africa

New England Journal of Medicine, 2021
In the six Southeast Asian countries that make up the Greater Mekong Subregion, Plasmodium falciparum has developed resistance to derivatives of artemisinin, the main component of first-line treatments for malaria. Clinical resistance to artemisinin monotherapy in other global regions, including Africa, would be problematic.In this longitudinal study ...
Betty Balikagala, Naoyuki Fukuda, Mie Ikeda, Osbert T. Katuro, Shin-Ichiro Tachibana, Masato Yamauchi, Walter Opio, Sakurako Emoto, Denis A. Anywar, Eisaku Kimura, Nirianne M.Q. Palacpac, Emmanuel I. Odongo-Aginya, Martin Ogwang, Toshihiro Horii, Toshihiro Mita   +14 more
openaire   +3 more sources

The costs of introducing artemisinin-based combination therapy: evidence from district-wide implementation in rural Tanzania. [PDF]

, 2008
BACKGROUND\ud \ud The development of antimalarial drug resistance has led to increasing calls for the introduction of artemisinin-based combination therapy (ACT).
Goodman Catherine A, Mulligan Jo, Abdulla, Salim, Bloland, Peter, McHomvu, Naiman, Mills, Anne, Mills Anne, Mchomvu Naiman, Munkondya John S, Njau Joseph D, Abdulla Salim, Munkondya, John S, Bloland Peter, Kachur, S Patrick, Njau, Joseph D, Goodman, Catherine A, Kachur S Patrick, Mulligan, Jo   +17 more
core   +1 more source

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites.

PLoS Pathogens, 2018
Due to their remarkable parasitocidal activity, artemisinins represent the key components of first-line therapies against Plasmodium falciparum malaria. However, the decline in efficacy of artemisinin-based drugs jeopardizes global efforts to control and
Frances Rocamora, Lei Zhu, Kek Yee Liong, Arjen Dondorp, Olivo Miotto, Sachel Mok, Zbynek Bozdech   +6 more
doaj   +1 more source

Dimeric Artesunate Glycerophosphocholine Conjugate Nano-Assemblies as Slow-Release Antimalarials to Overcome Kelch 13 Mutant Artemisinin Resistance

Antimicrobial Agents and Chemotherapy, 2022
Current best practice for the treatment of malaria relies on short half-life artemisinins that are failing against emerging Kelch 13 mutant parasite strains.
Yawei Du, Carlo Giannangelo, Wei He, Gerald J. Shami, Wen-Ya Zhou, Tuo Yang, D. Creek, C. Dogovski, Xin-Song Li, Leann Tilley   +9 more
semanticscholar   +1 more source

In vivo parasitological measures of artemisinin susceptibility [PDF]

, 2010
Parasite clearance data from 18,699 patients with falciparum malaria treated with an artemisinin derivative in areas of low (n=14,539), moderate (n=2077), and high (n=2083) levels of malaria transmission across the world were analyzed to determine the ...
Smithuis, F, Olliaro, P., Mayxay, Mayfong, Stepniewska, K., Newton, Paul N., de Vries, Peter J, Olliaro, P, Taylor, Walter R. J., Binh, Tran Quang, Ashley, E., de Vries, P. J., Newton, Paul N, Day, Nicholas PJ, D'Alessandro, U., Rowland, Mark, Mayxay, M, Guthmann, J. P., Ashley, E, Anstey, N., Dorsey, G, Barnes, K. I., Binh, TQ, Newton, PN, Guthmann, Jean-Paul, Lee, S. J., Stepniewska, K, Lee, Sue J, de Vries, Peter J., White, Nicholas, Lee, Sue J., Nosten, François, Anstey, N, White, Nicholas J., Guthmann, JP, Nosten, F., Lee, Sue, Barnes, KI, Taylor, W. R. J., White, N. J., Taylor, WR, Dorsey, Grant, Newton, P. N., de Vries, PJ, Osorio, L., Day, Nicholas P. J., Barnes, Karen I., White, Nicholas J, Rowland, M, Binh, T. Q., Taylor, Walter RJ, Day, NP, Smithuis, F., Nosten, F, Smithuis, Frank, Osorio, Lyda, Newton, Paul, Lee, SJ, Mayxay, M., Day, N. P. J., Barnes, Karen I, Dorsey, G., D'Alessandro, Umberto, Price, Ric N., Anstey, Nicholas, Day, Nicholas P J, Price, RN, Stepniewska, Kasia, Rowland, M., Day, Nicholas, Ashley, Elizabeth, Price, Ric N, Taylor, Walter R J, Osorio, L, D'Alessandro, U, White, NJ, Olliaro, Piero   +75 more
core   +1 more source

Molecular Evidence of Drug Resistance in Asymptomatic Malaria Infections, Myanmar, 2015

Emerging Infectious Diseases, 2017
Artemisinin resistance containment in Myanmar was initiated in 2011 after artemisinin-resistant Plasmodium falciparum malaria was reported. Molecular evidence suggests that asymptomatic malaria infections harboring drug resistance genes are present among
Myat Htut Nyunt, Thinzar Shein, Ni Ni Zaw, Soe Soe Han, Fauzi Muh, Seong-Kyun Lee, Jin-Hee Han, Kyaw Zin Thant, Eun-Taek Han, Myat Phone Kyaw   +9 more
doaj   +1 more source