Results 81 to 90 of about 5,742,584 (242)

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Saleability of Anti-malarials in Private Drug Shops in Muheza, Tanzania: A Baseline study in an era of assumed Artemisinin Ccombination Therapy (ACT). [PDF]

, 2011
Artemether-lumefantrine (ALu) replaced sulphadoxine-pymimethamine (SP) as the official first-line anti-malarial in Tanzania in November 2006. So far, artemisinin combination therapy (ACT) is contra-indicated during pregnancy by the national malaria ...
Massawe Isolide S, Bygbjerg Ib C, Ib C Bygbjerg, Martha M Lemnge, Ringsted Frank M, Lemnge Martha M, Lemnge, Martha M, Isolide S Massawe, Ringsted, Frank M, Massawe, Isolide S, Bygbjerg, Ib C, Frank M Ringsted   +11 more
core   +1 more source

Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance

eLife, 2020
Antimalarial drug resistance has historically arisen through convergent de novo mutations in Plasmodium falciparum parasite populations in Southeast Asia and South America.
L. Mathieu, H. Cox, A. Early, Sachel Mok, Y. Lazrek, Jeanne-Celeste Paquet, M. Ade, N. Lucchi, Quacy Grant, V. Udhayakumar, Jean S F Alexandre, M. Demar, P. Ringwald, D. Neafsey, D. Fidock, L. Musset   +15 more
semanticscholar   +1 more source

Assessment of Plasmodium falciparum Artemisinin Resistance Independent of kelch13 Polymorphisms and with Escalating Malaria in Bangladesh

mBio, 2022
Malaria elimination is a Millennium Development Goal. Artemisinins, fast-acting antimalarial drugs, have played a key role in malaria elimination. ABSTRACT Emerging resistance to artemisinin drugs threatens the elimination of malaria.
Maisha Khair Nima, A. Mukherjee, Saiful Arefeen Sazed, M. R. Hossainey, C. S. Phru, F. Johora, I. Safeukui, Anjan Saha, A. Khan, A. S. Marma, R. Ware, N. Mohandas, Barbara Calhoun, R. Haque, W. Khan, M. Alam, K. Haldar   +16 more
semanticscholar   +1 more source

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source

Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia. [PDF]

, 2012
Recent studies have shown that Plasmodium falciparum malaria parasites in Pailin province, along the border between Thailand and Cambodia, have become resistant to artemisinin derivatives. To better define the epidemiology of P.
Yeang, Chhiang, Shunmay Yeung, Nguon, Sokomar, Chea, Nguon, Thomson Andrew, Chhiang Yeang (130756), Steven Bjorge (130709), Khim Nimol, Samphornarann Top (130727), Habib, Najibullah, Robert D Newman, Andrew Thomson (23309), Menard, Didier, Sovann Yok, Kim Saorin, Kim, Saorin, Sophal, Uth, Bjorge Steven, Benoit Witkowski, Didier Menard (2577220), Najibullah Habib, Michelle M Thompson, Steven Bjorge, Sarorn Sum, Didier Menard, Nimol Khim (130700), Andrew Thomson, Christophel Eva-Maria, Ros, Seyha, Mellor Steve, Top Samphornarann, Hoyer Stefan, Bjorge, Steven, Socheat Duong, Saorin Kim, Menard Didier, Kheng, Sim, Nguon Chea, Hoyer, Stefan, Top, Samphornarann, Sokomar Nguon, Najibullah Habib (130696), Thompson Michelle M., Robert D. Newman (130763), Sarorn Sum (130703), Sophal Uth, Witkowski Benoit, Witkowski, Benoit, Sovann Yok (130723), Socheat Duong (130761), Newman, Robert D, Nguon Sokomar, Uth Sophal, Michelle M. Thompson, Michelle M. Thompson (130739), Duong, Socheat, Kheng Sim, Seyha Ros (130731), Mellor, Steve, Yeung, Shunmay, Chhiang Yeang, Ariey Frédéric, Seyha Ros, Samphornarann Top, Saorin Kim (130692), Christophel, Eva-Maria, Khim, Nimol, Steve Mellor, Sim Kheng (130715), Uth Sophal (130734), Chea Nguon, Eva-Maria Christophel, Nguon Chea (130719), Yok Sovann, Frédéric Ariey (92228), Ros Seyha, Sum, Sarorn, Nimol Khim, Thomson, Andrew, Frédéric Ariey, Yeang Chhiang, Newman Robert D., Sum Sarorn, Thompson, Michelle M, Habib Najibullah, Ariey, Frédéric, Duong Socheat, Yeung Shunmay, Eva-Maria Christophel (130705), Sim Kheng, Sokomar Nguon (130689), Stefan Hoyer (130687), Stefan Hoyer, Yok, Sovann, Robert D. Newman, Steve Mellor (130744), Benoit Witkowski (130751), Shunmay Yeung (53391)   +97 more
core   +1 more source

The emergence of artemisinin partial resistance in Africa: how do we respond?

Lancet. Infectious Diseases (Print)
Malaria remains one of the most important infectious diseases in the world, with the greatest burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The treatment and control of malaria is challenged by resistance to most available
Philip J. Rosenthal, V. Asua, J. A. Bailey, M. Conrad, D. Ishengoma, M. Kamya, Charlotte Rasmussen, F. Tadesse, A. Uwimana, D. Fidock   +9 more
semanticscholar   +1 more source

Integration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparum

International Journal for Parasitology: Drugs and Drug Resistance, 2021
Resistance to antimalarial drugs, and in particular to the artemisinin derivatives and their partner drugs, threatens recent progress toward regional malaria elimination and eventual global malaria eradication.
J. Oberstaller, L. Zoungrana, Carl D. Bannerman, S. Jahangiri, A. Dwivedi, Joana C. Silva, J. Adams, Shannon Takala-Harrison   +7 more
semanticscholar   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Are Tanzanian patients attending public facilities or private retailers more likely to adhere to artemisinin-based combination therapy? [PDF]

, 2015
BACKGROUND: Artemisinin combination therapy (ACT) is first-line treatment for malaria in most endemic countries and is increasingly available in the private sector. Most studies on ACT adherence have been conducted in the public sector, with minimal data
Catherine Goodman, Schellenberg, David, Kalolella, Admirabilis, Katia Bruxvoort, Bruxvoort, Katia, Matthew Cairns, Festo, Charles, Charles Festo, David Schellenberg, Peter Lyaruu, S Kachur, Goodman, Catherine, Kenani, Mitya, Kachur, S Patrick, Lyaruu, Peter, Admirabilis Kalolella, Mitya Kenani, Cairns, Matthew   +17 more
core   +1 more source