Results 101 to 110 of about 5,742,584 (242)

Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells. [PDF]

, 2011
Breast cancer is the most common cancer and the second leading cause of cancer death in industrialized countries. Systemic treatment of breast cancer is effective at the beginning of therapy.
Ulrich Pfeffer, Killian, Peter H., Fichtner Iduna, Efferth, Thomas, Iduna Fichtner, Pfeffer Ulrich, Pfeffer, U., Emanuel Kronski, Bachmeier Beatrice, Killian, P.H., Fichtner, I., Beatrice Bachmeier, Bachmeier, B., Thomas Efferth, Kronski, Emanuel, Efferth Thomas, Kronski, E., Pfeffer, Ulrich, Fichtner, Iduna, Bachmeier, Beatrice, Peter H. Killian, Peter H Killian, Efferth, T., Kronski Emanuel, Killian Peter H.   +24 more
core   +1 more source

Detection of mutations associated with artemisinin resistance at k13-propeller gene and a near complete return of chloroquine susceptible falciparum malaria in Southeast of Tanzania

Scientific Reports, 2020
In Tanzania, chloroquine was replaced by sulphadoxine- pyrimethamine (SP) as a first-line for treatment of uncomplicated malaria. Due to high resistance in malaria parasites, SP lasted for only 5 years and by the end of 2006 it was replaced with the ...
G. Bwire, B. Ngasala, W. Mikomangwa, M. Kilonzi, Appolinary A. R. Kamuhabwa   +4 more
semanticscholar   +1 more source

Country wide surveillance reveals prevalent artemisinin partial resistance mutations with evidence for multiple origins and expansion of high level sulfadoxine-pyrimethamine resistance mutations in northwest Tanzania

medRxiv, 2023
Background: Emergence of artemisinin partial resistance (ArtR) in Plasmodium falciparum in East Africa is a growing threat to the efficacy of artemisinin combination therapies (ACT) and the global efforts for malaria elimination.
J. Juliano, D. Giesbrecht, A. Simkin, A. Fola, B. Lyimo, D. Perus, C. Bakari, R. Madebe, M. D. Seth, C. Mandara, Z. R. Popkin-Hall, R. Moshi, R. B. Mbwambo, K. Niaré, B. MacInnis, F. Francis, D. Mbwambo, I. Garimo, Frank Chacky, S. Aaron, A. Lusasi, F. Molteni, R. Njau, S. Lazaro, A. Mohamed, J. A. Bailey, D. Ishengoma   +26 more
semanticscholar   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Coartem: the Journey to the Clinic. [PDF]

, 2009
Artemisinin, from which the artemether component of Coartem (artemether/lumefantrine, AL) is derived, is obtained from the plant sweet wormwood (Artemisia annua) which has been used for over 2,000 years as a Chinese herbal remedy.
Premji, Zulfiqarali G, Premji, Z.G., Premji, Zul   +2 more
core   +1 more source

Antimalarial qinghaosu/artemisinin: The therapy worthy of a Nobel Prize

Asian Pacific Journal of Tropical Biomedicine, 2016
Malaria is a major cause of human morbidity and mortality in the tropical endemic countries worldwide. This is largely due to the emergence and spread of resistance to most antimalarial drugs currently available.
Jerapan Krungkrai, Sudaratana Rochanakij Krungkrai   +1 more
doaj   +1 more source

Resistance screening and trend analysis of imported falciparum malaria in NSW, Australia (2010 to 2016). [PDF]

PLoS ONE, 2018
BACKGROUND:The World Health Organization currently recommends artemisinin (along with a partner drug) as the global frontline treatment for Plasmodium falciparum malaria. Artemisinin resistant P.
Christiane Prosser, Wieland Meyer, John Ellis, Rogan Lee   +3 more
doaj   +1 more source

Implicating extracellular vesicles in Plasmodium falciparum artemisinin resistance development

Traffic : the International Journal of Intracellular Transport, 2021
Plasmodium falciparum malaria remains a disease of significant public health impact today. With the risk of emerging artemisinin resistance stalling malaria control efforts, the need to deepen our understanding of the parasite's biology is dire ...
K. Tandoh, M. Wilson, N. Quashie, N. Duah-Quashie   +3 more
semanticscholar   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

"Plasmodium falciparum" Drug Resistance, Molecular Genotyping and Generation of a Malaria Resistance Genogram by DNA Microarray-Based Technology [PDF]

, 2006
Prior to the 2001 malarial treatment policy change in Tanzania, studies were conducted to assess the efficacy of sulfadoxine-pyrimethamine (SP) and usefulness of molecular markers in monitoring SP resistance.
Mugittu, Kefas Nasongelya
core   +1 more source