Results 111 to 120 of about 5,742,584 (242)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Culture-adapted Plasmodium falciparum isolates from UK travellers: in vitro drug sensitivity, clonality and drug resistance markers. [PDF]

, 2013
BACKGROUND: The screening of lead compounds against in vitro parasite cultures is an essential step in the development of novel anti-malarial drugs, but currently relies on laboratory parasite lines established in vitro during the last century.
Sutherland, CJ, van Schalkwyk, DA, Wright, Stephen G, Henriques, G, Burrow, Rebekah, Beshir, Khalid B, Beshir, KB, Hasford, Christian, Hasford, C, Ding, XC, Gadalla, Nahla B, Chiodini, Peter L, Sutherland, Colin J, van Schalkwyk, Donelly A, Henriques, Gisela, Gadalla, NB, Wright, SG, Ding, Xavier C, Chiodini, PL   +18 more
core   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

Artemisinin-based combination therapy does not measurably reduce human infectiousness to vectors in a setting of intense malaria transmission [PDF]

, 2012
<p>Background: Artemisinin-based combination therapy (ACT) for treating malaria has activity against immature gametocytes. In theory, this property may complement the effect of terminating otherwise lengthy malaria infections and reducing the ...
Huho, B. J., Charlwood, J Derek, Kihonda, Japhet, Adriana Tami, Christian Lengeler, Huho, B.J., Huho Bernadette J, Heather M Ferguson, Smith, T., Tami, A., Lengeler Christian, Killeen, G. F., Abdulla, Salim M. K., Killeen, Gerard F., J Derek Charlwood, Lengeler, Christian, Aniset Kihonda, Smith, T. A., Salim MK Abdulla, Huho, Bernadette J., Kachur, S Patrick, Charlwood J Derek, Japhet Kihonda, Charlwood, J D, Charlwood, D.J., Smith, Thomas A, Thomas A Smith, Ferguson, Heather M, Killeen, G.F., Abdulla, S. M., Abdulla, S.K., Abdulla, Salim MK, Ferguson, H., Killeen Gerard F, Kihonda, A., Kachur, S.P., Huho, Bernadette J, Kihonda, J., Killeen, Gerry, Abdulla Salim MK, Kachur S Patrick, Smith, Thomas A., Killeen, Gerard F, Kihonda Japhet, Tami, Adriana, Kihonda Aniset, Gerard F Killeen, Tami Adriana, S Patrick Kachur, Charlwood, J. Derek, Lengeler, C., Ferguson, Heather M., Kachur, S. Patrick, Kihonda, Anisette, Ferguson Heather M, Abdulla, Salim M, Kihonda, Aniset, Ferguson, H. M., Charlwood, J. D., Kachur, S. P., Tami, Adriana; id_orcid, Smith Thomas A, Bernadette J Huho   +62 more
core   +2 more sources

High-level artemisinin-resistance with quinine co-resistance emerges in P. falciparum malaria under in vivo artesunate pressure

BMC Medicine, 2018
Background Humanity has become largely dependent on artemisinin derivatives for both the treatment and control of malaria, with few alternatives available.
Rajeev K. Tyagi, Patrick J. Gleeson, Ludovic Arnold, Rachida Tahar, Eric Prieur, Laurent Decosterd, Jean-Louis Pérignon, Piero Olliaro, Pierre Druilhe   +8 more
doaj   +1 more source

Time to scale up molecular surveillance for anti-malarial drug resistance in sub-saharan Africa

Malaria Journal, 2021
Artemisinin resistance has emerged and spread in the Greater Mekong Sub-region (GMS), followed by artemisinin-based combination therapy failure, due to both artemisinin and partner drug resistance.
Christian Nsanzabana
doaj   +1 more source

Targeting the NR3C1‐ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer

Cancer Science, EarlyView.
The glucocorticoid receptor NR3C1 drives prostate cancer radioresistance by upregulating ACSL4. High ACSL4 levels create a lipid metabolic vulnerability. The clinical agent DHA synergizes with ACSL4 to induce lipid peroxidation and ferroptosis, effectively overcoming radioresistance.
Jing Yang, Puyuan Chen, Yawen Zheng, Feiyue Shi, Min Wang, Luwei Xu, Xiaowei Wei, Xiumei Wang   +7 more
wiley   +1 more source

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. [PDF]

, 2008
BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Hastings, Ian M, Day, Nicholas PJ, White, Nicholas J., Dondorp, AM, Hastings, Ian M., Dondorp, Arjen M, Dondorp, Adrianus, Hastings, Ian, Day, Nicholas P. J., Pongtavornpinyo, W, Hastings, IM, Pongtavornpinyo, Wirichada, White, Nicholas J, Day, Nicholas, Day, Nicholas P.J., Yeung, Shunmay, Day, NP, White, NJ, White, Nicholas, Dondorp, Arjen M., Yeung, S, Hastings Ian M, Dondorp Arjen M, Pongtavornpinyo Wirichada, Day Nicholas PJ, Yeung Shunmay, White Nicholas J   +26 more
core   +1 more source

Pyrvinium pamoate can overcome artemisinin’s resistance in anaplastic thyroid cancer

BMC Complementary Medicine and Therapies, 2021
Background Anaplastic thyroid carcinoma is a highly lethal subtype of thyroid cancer without effective therapies. Drug resistance in anaplastic thyroid carcinoma poses a significant problem. Although artemisinin exerts antitumor effects, but its efficacy
Yitian Li
doaj   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source