Results 91 to 100 of about 5,742,584 (242)

In Vitro and In Silico Antimalarial Evaluation of FM-AZ, a New Artemisinin Derivative

Medicines, 2022
Artemisinin-based Combination Therapies (ACTs) are currently the frontline treatment against Plasmodium falciparum malaria, but parasite resistance to artemisinin (ART) and its derivatives, core components of ACTs, is spreading in the Mekong countries ...
Ioannis Tsamesidis, Farnoush Mousavizadeh, Chinedu O. Egwu, Dionysia Amanatidou, Antonella Pantaleo, Françoise Benoit-Vical, Karine Reybier, Athanassios Giannis   +7 more
doaj   +1 more source

Evidence of artemisinin partial resistance in northwestern Tanzania: clinical and molecular markers of resistance

Lancet. Infectious Diseases (Print)
Summary Background In 2021, nationwide malaria molecular surveillance revealed a high prevalence of a validated artemisinin resistance marker, the kelch13 (k13) Arg561His mutation, in the Kagera region of northwestern Tanzania.
D. Ishengoma, C. Mandara, C. Bakari, A. Fola, R. Madebe, M. D. Seth, F. Francis, Creyton C Buguzi, R. Moshi, I. Garimo, S. Lazaro, A. Lusasi, Sijenunu Aaron, Frank Chacky, A. Mohamed, Ritha J. A. Njau, J. Kitau, Charlotte Rasmussen, J. A. Bailey, Jonathan J. Juliano, M. Warsame   +20 more
semanticscholar   +1 more source

Artemisinin Bioactivity and Resistance in Malaria Parasites

Trends in Parasitology, 2019
Artemisinin is the most widely-used compound against malaria and plays a critical role in the treatment of malaria worldwide. Resistance to artemisinin emerged about a decade ago in Southeast Asia and it is paramount to prevent its spread or emergence in Africa. Artemisinin has a complex mode of action and can cause widespread injury to many components
Talman, Arthur, Clain, Jérôme, Duval, Romain, Ménard, Robert, Ariey, Frédéric   +4 more
openaire   +3 more sources

Truncation of Samroiyotmycin: Tailored seco‐Acids as Novel Antimalaria Compounds

European Journal of Organic Chemistry, EarlyView.
Six truncated samroiyotmycin‐derived antimalarials were synthesized by replacing the tosyloxazole unit with electron‐deficient aryl groups. The most active seco‐acid with EWG = 2 × CF3 outperformed the natural product SamA. Its enhanced activity supports a donor–acceptor interaction involving the electron‐poor aryl unit, consistent with inhibition of ...
Anton Czuczkowski, Anja Schäfer, Juliana A. Hüther, Bianca Wank, Robert Toews, Fotios Fotakis, Andreas Köhn, Markus Rehm, Matthias Rottmann, Anna Zens, Sabine Laschat   +10 more
wiley   +1 more source

Induction of high tolerance to artemisinin by sub-lethal administration: A new in vitro model of P. falciparum. [PDF]

PLoS ONE, 2018
Artemisinin resistance is a major threat to malaria control efforts. Resistance is characterized by an increase in the Plasmodium falciparum parasite clearance half-life following treatment with artemisinin-based combination therapies (ACTs) and an ...
Serena De Lucia, Ioannis Tsamesidis, Maria Carmina Pau, Kristina R Kesely, Antonella Pantaleo, Francesco Turrini   +5 more
doaj   +1 more source

Emergence of Plasmodium falciparum strains with artemisinin partial resistance in East Africa and the Horn of Africa: is there a need to panic?

Malaria Journal
The emergence and spread of artemisinin partial resistance in East and Horn of Africa is alarming. However, artemisinin-based combination therapy (ACT) generally remains efficacious for the treatment of falciparum malaria.
A. Assefa, A. Fola, G. Tasew
semanticscholar   +1 more source

Bridging Worlds: Can Evidence, Regulation and Indigenous Leadership Shape the Future of Traditional, Complementary and Integrative Medicine?

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Background and need As the WHO Global Traditional Medicine Strategy 2025–2034 encourages countries to consider integrating traditional, complementary and integrative medicine (TCIM) into health systems, there is a need to clarify the principal scientific, regulatory, ethical, and governance challenges involved. Renewed global attention to TCIM,
Abdul‐Basit Abdul‐Samed, Dina Balabanova, Neil Spicer, Martin McKee   +3 more
wiley   +1 more source

Efficacy of Artemether-Lumefantrine in Treatment of Malaria Among Under-Fives and Prevalence of Drug Resistance Markers in Igombe-Mwanza, North-Western Tanzania. [PDF]

, 2012
\ud \ud Drug resistance to anti-malarials is a major public health problem worldwide. This study aimed at establishing the efficacy of artemether-lumefantrine (ACT) in Igombe-Mwanza, north-western Tanzania after a few years of ACT use, and establish the ...
Kamugisha, Erasmus, Minde Mercy, Kataraihya Johaness, Kironde, Fred, Kamugisha Erasmus, Erasmus Kamugisha, Jing, Sun, Kongola Gilbert, Mercy Minde, Kironde Fred, Jing Sun, Swedberg, Göte, Johaness Kataraihya, Kataraihya, Johaness, Swedberg Göte, Sun Jing, Gilbert Kongola, Kongola, Gilbert, Minde, Mercy, Fred Kironde, Göte Swedberg   +20 more
core   +1 more source

Pre-existing partner-drug resistance facilitates the emergence and spread of artemisinin resistance: a consensus modelling study

bioRxiv, 2021
Background Artemisinin-resistant genotypes have now emerged a minimum of five times on three continents despite recommendations that all artemisinins be deployed as artemisinin combination therapies (ACTs).
O. Watson, B. Gao, Tran Dang Nguyen, T. N. Tran, M. Penny, David L. Smith, L. Okell, R. Águas, M. F. Boni   +8 more
semanticscholar   +1 more source

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source