Results 71 to 80 of about 5,742,584 (242)

Rational deployment of antimalarial drugs in Africa: should first-line combination drugs be reserved for paediatric malaria cases? [PDF]

, 2011
Artemisinin-based combination therapy is exerting novel selective pressure upon populations of Plasmodium falciparum across Africa. Levels of resistance to non-artemisinin partner drugs differ among parasite populations, and so the artemisinins are not ...
Mackinnon, Margaret J, Sutherland, CJ, Ranford-Cartwright, L, COLIN J. SUTHERLAND, MARGARET J. MACKINNON, Babiker, H., MacKinnon, M.J., El Sayed, BB, HAMZA BABIKER, Sutherland, Colin J, Ranford-Cartwright, Lisa, Mackinnon, Margaret, El Sayed, Badria Babiker, Sayed, B.B., Sutherland, C.J., Babiker, H, Ranford-Cartwright, L.C., LISA RANFORD-CARTWRIGHT, BADRIA BABIKER EL SAYED, Babiker, Hamza   +19 more
core   +1 more source

Piloting the global subsidy: the impact of subsidized artemisinin-based combination therapies distributed through private drug shops in rural Tanzania. [PDF]

, 2009
BACKGROUND: WHO estimates that only 3% of fever patients use recommended artemisinin-based combination therapies (ACTs), partly reflecting their high prices in the retail sector from where many patients seek treatment.
Catherine Goodman, Ward Lorrayne, Mwita, Alex, Oliver J Sabot, Odhiambo, Moses, Odhiambo Moses, Ipuge, Yahya, Sabot Oliver J., Cohen Justin M., Gordon Megumi, Bishop David, Justin M Cohen, Bishop, David, Moses Odhiambo, Megumi Gordon, Goodman Catherine, Ipuge Yahya, Gordon, Megumi, Cohen, Justin M, Sabot, Oliver J, Lorrayne Ward, Ward, Lorrayne, Mwita Alex, Goodman, Catherine, David Bishop, Yahya Ipuge, Alex Mwita   +26 more
core   +2 more sources

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children. [PDF]

, 2008
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with implications for changes in treatment policy.
Pinoges Loretxu, Balkan, S, Grant Dorsey, Pinoges, Loretxu, Hasifa Burkirwa, Olliaro, P, Pedro Pablo Palma Urruta, Checchi, Francesco, Ingrid van den Broek, Dorsey Grant, Urruta, P P P, Walter R Taylor, Michel van Herp, Ashley Elizabeth A, Dorsey, G, van Herp Michel, Turyakira, Eleanor, Guthmann, Jean-Paul, Ashley, Elizabeth A, Zongo Issaka, Taylor Walter R, van Herp, M, Francesco Checchi, Issaka Zongo, Turyakira, E, Zongo, I, Taylor, W R J, Balkan Suna, Dorsey, Grant, van den Broek Ingrid, van Herp, Michel, Ashley, E A, van den Broek, Ingrid, Taylor, Walter R, Urruta, Pedro Pablo Palma, Elizabeth A Ashley, Eleanor Turyakira, Olliaro Piero, Pinoges, L, Jean-Paul Guthmann, Guthmann, J P, Guthmann Jean-Paul, van den Broek, I, Piero Olliaro, Zongo, Issaka, Checchi Francesco, Bukirwa, H, Checchi, F, Loretxu Pinoges, Bukirwa, Hasifa, Turyakira Eleanor, Suna Balkan, Bukirwa Hasifa, Urruta Pedro, Balkan, Suna, Olliaro, Piero   +55 more
core   +1 more source

Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine

International Journal for Parasitology: Drugs and Drug Resistance, 2019
Artemisinin derivatives and their partner drugs in artemisinin combination therapies (ACTs) have played a pivotal role in global malaria mortality reduction during the last two decades.
Duangkamon Loesbanluechai, Namfon Kotanan, Cristina de Cozar, Theerarat Kochakarn, Megan R. Ansbro, Kesinee Chotivanich, Nicholas J. White, Prapon Wilairat, Marcus C.S. Lee, Francisco Javier Gamo, Laura Maria Sanz, Thanat Chookajorn, Krittikorn Kümpornsin   +12 more
doaj   +1 more source

Artemisinin-resistant malaria

Clinical Microbiology Reviews
SUMMARY The artemisinin antimalarials are the cornerstone of current malaria treatment. The development of artemisinin resistance in Plasmodium falciparum poses a major threat to malaria control and elimination.
N. J. White, K. Chotivanich
openaire   +3 more sources

Nicotiana benthamiana as a Production Platform for Artemisinin Precursors [PDF]

, 2010
Background Production of pharmaceuticals in plants provides an alternative for chemical synthesis, fermentation or natural sources. Nicotiana benthamiana is deployed at commercial scale for production of therapeutic proteins.
Herpen, T.W.J.M., van, Nogueira, M., Teun W J M van Herpen, van Herpen Teun W. J. M., Harro J. Bouwmeester, Cankar, Katarina, Katarina Cankar, Harpen, Teun W. J. M. van, Marilise Nogueira, Dirk Bosch, Harro J Bouwmeester, Bouwmeester Harro J., Beekwilder, Jules, Jules Beekwilder, Teun W. J. M. van Herpen, Nogueira Marilise, Cankar, K., van Herpen, T.W.J.M., Cankar Katarina, Beekwilder Jules, Bouwmeester, Harro, Nogueira, Marilise, Bosch, H.J., Bosch Dirk, Bouwmeester, H.J., Beekwilder, M.J., Bosch, Dirk   +26 more
core   +1 more source

K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair

Cell Reports, 2020
Summary: Southeast Asia has been the hotbed for the development of drug-resistant malaria parasites, including those with resistance to artemisinin combination therapy.
Aoli Xiong, Prem Prakash, Xiaohong Gao, Marvin Chew, Ian Jun Jie Tay, Charles J. Woodrow, Bevin P. Engelward, Jongyoon Han, Peter R. Preiser   +8 more
doaj   +1 more source

Mutation in the Plasmodium falciparum BTB/POZ Domain of K13 Protein Confers Artemisinin Resistance

Antimicrobial Agents and Chemotherapy, 2021
Partial artemisinin resistance, defined in patients as a delayed parasite clearance following artemisinin-based treatment, is conferred by non-synonymous mutations in the Kelch beta-propeller domain of the Plasmodium falciparum k13 (pfk13) gene. Here, we
L. Paloque, R. Coppée, Barbara H. Stokes, Nina F. Gnädig, K. Niaré, J. Augereau, D. Fidock, J. Clain, F. Benoit-Vical   +8 more
semanticscholar   +1 more source

Plasmodium falciparum: multifaceted resistance to artemisinins [PDF]

Malaria Journal, 2016
Plasmodium falciparum resistance to artemisinins, the most potent and fastest acting anti-malarials, threatens malaria elimination strategies. Artemisinin resistance is due to mutation of the PfK13 propeller domain and involves an unconventional mechanism based on a quiescence state leading to parasite recrudescence as soon as drug pressure is removed.
Paloque, Lucie, Ramadani, Arba Pramundita, Mercereau-Puijalon, Odile, Augereau, Jean-Michel, Benoit-Vical, Françoise   +4 more
openaire   +3 more sources

Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials. [PDF]

, 2008
BACKGROUND: Artemisinin combination therapies (ACT), which are increasingly being introduced for treatment of Plasmodium falciparum malaria, are more effective against sexual stage parasites (gametocytes) than previous first-line antimalarials and ...
Drakeley, Chris J, Bousema, Teun, Sutherland, CJ, Lucy C Okell, Bousema, T, Ghani, Azra C, Sutherland Colin J, Drakeley Chris J, Drakeley, CJ, Colin J Sutherland, Okell Lucy C, Bousema Teun, Okell, Lucy C, Azra C Ghani, Sutherland, Colin J, Ghani Azra C, Ghani, AC, Teun Bousema, Okell, LC, Chris J Drakeley   +19 more
core   +1 more source