Results 51 to 60 of about 5,742,584 (242)

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]

, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Kamugisha, Erasmus, Piola, Patrice, Faucher, Jean-François, El-Sayed, Badria, Houzé, Sandrine, Somé, A Fabrice, Sutherland, Colin, Checchi, Francesco, Plowe, Christopher, V, Sutherland, Colin J, Otienoburu, Sabina Dahlström, Berens-Riha, Nicole, Grivoyannis, Anastasia, Davis, Timothy ME, Björkman, Anders, Asaq Molecular Marker Study Group, Rosenthal, Philip, Eyase, Frederick, Malmberg, Maja, Kariuki, Simon, Mårtensson, Andreas,, Hamour, Sally, Ogutu, Bernhards, Davis, Timothy, Wong, Rina, Sibley, Carol Hopkins, Gadalla, Nahla B, Ngasala, Billy, Ménard, Didier, Oguike, Mary, Venkatesan, Meera, Arze, Cesar, Djimdé, Abdoulaye A, Baliraine, Frederick N, Fröberg, Gabrielle, Ursing, Johan, LeBras, Jacques, Desai, Meghna, Mårtensson, Andreas, Ouédraogo, Jean-Bosco, El-Sayed, Badria B, Mwai, Leah, Thwing, Julie, Kironde, Fred, Djimde, Abdoulaye, Price, Ric, Dorsey, Grant, Johnson, Jacob, Guérin, Philippe, Somé, A. Fabrice, Oguike, Alexis Nzila Mary, LeBras, Poul-Erik Kofoed Jacques, Moriera, Clarissa, Kiechel, Jean-René, Kofoed, Poul-Erik, Dahal, Prabin, Nsanzabana, Christian, Nzila, Alexis, Wong, Rina PM, Rosenthal, Philip J, Ademowo, George, Falade, Catherine, Nsobya, Samuel L, Schramm, Birgit, Zongo, Issaka, Gadalla, Nahla, Wong, Rina P M, Plowe, Christopher V, Eshetu, Teferi, Davis, Timothy M E, Dhorda, Meghna Desai Mehul, Plowe, Christopher,, Rombo, Lars,, Dhorda, Mehul, Stepniewska, Kasia, Adam, Ishag, Price, Ric N, Borrmann, Steffen, Nosten, Francois, Rombo, Lars, Baliraine, Frederick, Zeynudin, Ahmed, Nsobya, Samuel   +82 more
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Worldwide Research Trends on Artemisinin: A Bibliometric Analysis From 2000 to 2021

Frontiers in Medicine, 2022
ObjectiveArtemisinin is an organic compound that comes from Artemisia annua. Artemisinin treatment is the most important and effective method for treating malaria.
Yankai Dong, Lina Liu, Jie Han, Lianqing Zhang, Yi Wang, Juan Li, Yuexiang Li, He Liu, Kun Zhou, Luyao Li, Xin Wang, Xue Shen, Meiling Zhang, Bo Zhang, Xiaofei Hu   +14 more
doaj   +1 more source

Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. [PDF]

, 2012
BACKGROUND: Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins.
Rosalba Lepore, LEPORE, ROSALBA, Pillai, DR, Via Allegra, K. Khairnar, Khairnar Krishna, Rachel Lau, Pillai Dylan R, D. R. Pillai, VIA, ALLEGRA, Dylan R Pillai, Henry M Staines, Krishna Sanjeev, S. Krishna, Lau, R, Khairnar, K, Lau Rachel, Via, A, Staines, HM, H. M. Staines, Krishna, S, Sanjeev Krishna, Krishna Khairnar, Lepore, R, Allegra Via, R. Lau, Lepore Rosalba, Staines Henry M   +27 more
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Functional analysis of Plasmodium falciparum subpopulations associated with artemisinin resistance in Cambodia

Malaria Journal, 2017
Background Plasmodium falciparum malaria is one of the most widespread parasitic infections in humans and remains a leading global health concern. Malaria elimination efforts are threatened by the emergence and spread of resistance to artemisinin-based ...
Ankit Dwivedi, Christelle Reynes, Axel Kuehn, Daniel B. Roche, Nimol Khim, Maxim Hebrard, Sylvain Milanesi, Eric Rivals, Roger Frutos, Didier Menard, Choukri Ben Mamoun, Jacques Colinge, Emmanuel Cornillot   +12 more
doaj   +1 more source

Mapping genetic markers of artemisinin resistance in Plasmodium falciparum malaria in Asia: a systematic review and spatiotemporal analysis

The Lancet Microbe, 2022
Summary Background The increase in artemisinin resistance threatens malaria elimination in Asia by the target date of 2030 and could derail control efforts in other endemic regions.
F. Kagoro, K. Barnes, K. Marsh, N. Ekapirat, Chris Erwin G. Mercado, I. Sinha, G. Humphreys, M. Dhorda, P. Guérin, R. Maude   +9 more
semanticscholar   +1 more source

Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. [PDF]

, 2005
BACKGROUND: Drug resistance in Plasmodium falciparum poses a major threat to malaria control. Combination antimalarial therapy including artemisinins has been advocated recently to improve efficacy and limit the spread of resistance, but artemisinins are
Albert Kilian, Sarah G Staedke (18026), Grant Dorsey, Yeka Adoke, Dorsey Grant, Kilian Albert, Kristin Banek (18020), Rosenthal Philip J, Grant Dorsey (18025), Moses R Kamya (18018), Reingold, Arthur, Nathan Bakyaita, Banek, Kristin, Staedke, Sarah G, Rosenthal, Philip J., Arthur Reingold (275222), Philip J Rosenthal (18023), Samuel L Nsobya (275219), Banek Kristin, Fred Wabwire-Mangen (18024), Kamya, Moses.R, Albert Kilian (275220), Madeline Slater (275221), Kamya Moses R, Arthur Reingold, Wabwire-Mangen Fred, Fred Wabwire-Mangen, Wabwire-Mangen, Fred, Staedke Sarah G, Sarah G Staedke, Moses R Kamya, Kristin Banek, Kironde, Fred, Slater, Madeline, Dorsey, Grant, Nsobya, Samuel L., Reingold Arthur, Ambrose Talisuna, Fred Kironde (44975), Kilian, Albert, Talisuna, Ambrose, Bakyaita, Nathan, Fred Kironde, Madeline Slater, Rosenthal, Philip J, Nsobya, Samuel L, Ambrose Talisuna (18019), Slater Madeline, Yeka, Adoke, Nsobya Samuel L, Bakyaita Nathan, Kironde Fred, Philip J Rosenthal, Talisuna Ambrose, Adoke Yeka, Samuel L Nsobya, Kamya, Moses R, Staedke, Sarah G., Nathan Bakyaita (18021), Adoke Yeka (18017)   +59 more
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Identifying artemisinin resistance from parasite clearance half-life data with a simple Shiny web application. [PDF]

PLoS ONE, 2017
The emergence of artemisinin-resistant Plasmodium falciparum malaria is a major threat to malaria elimination. New tools for supporting the surveillance of artemisinin resistance are critical for current and future malaria control and elimination ...
Sai Thein Than Tun, Yoel Lubell, Arjen M Dondorp, Tom Fieldman, Kyaw Myo Tun, Olivier Celhay, Xin Hui Chan, Sompob Saralamba, Lisa J White   +8 more
doaj   +1 more source

In Vitro Confirmation of Artemisinin Resistance in Plasmodium falciparum from Patient Isolates, Southern Rwanda, 2019

Emerging Infectious Diseases, 2022
Artemisinin resistance in Plasmodium falciparum is conferred by mutations in the kelch 13 (K13) gene. In Rwanda, K13 mutations have increased over the past decade, including mutations associated with delayed parasite clearance.
Welmoed van Loon, Rafael Oliveira, C. Bergmann, F. Habarugira, J. Ndoli, Augustin Sendegeya, C. Bayingana, F. Mockenhaupt   +7 more
semanticscholar   +1 more source

Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. [PDF]

, 2006
OBJECTIVES: To compare the efficacy and safety of artemisinin combination therapies for the treatment of uncomplicated falciparum malaria in Uganda. DESIGN: Randomized single-blind controlled trial.
Staedke Sarah G, Rosenthal, Philip J, Yeka, Adoke, Banek, Kristin, Yeka Adoke, Dorsey, Grant, Staedke, Sarah G, Bakyaita Nathan, Dorsey Grant, Banek Kristin, Bukirwa, Hasifa, Talisuna Ambrose, Rosenthal Philip J, Talisuna, Ambrose, Rwakimari, John Bosco, Kamya Moses R, Kamya, Moses R, Bukirwa Hasifa, Wabwire-Mangen Fred, Bakyaita, Nathan, Wabwire-Mangen, Fred, Rwakimari John Bosco   +21 more
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Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum.

PLoS Pathogens, 2023
Resistance of the human malaria parasites, Plasmodium falciparum, to artemisinins is now fully established in Southeast Asia and is gradually emerging in Sub-Saharan Africa.
Michal Kucharski, Grennady Wirjanata, Sourav Nayak, Josephine Boentoro, Jerzy Michal Dziekan, Christina Assisi, Rob W van der Pluijm, Olivo Miotto, Sachel Mok, Arjen M Dondorp, Zbynek Bozdech   +10 more
doaj   +1 more source