Results 31 to 40 of about 5,742,584 (242)

Expansion of artemisinin partial resistance mutations and lack of histidine rich protein-2 and -3 deletions in Plasmodium falciparum infections from Rukara, Rwanda

Malaria Journal
Background Emerging artemisinin partial resistance and diagnostic resistance are a threat to malaria control in Africa. Plasmodium falciparum kelch13 (k13) propeller-domain mutations that confer artemisinin partial resistance have emerged in Africa.
Cecile Schreidah, David Giesbrecht, Pierre Gashema, Neeva Wernsman Young, Tharcisse Munyaneza, Claude Mambo Muvunyi, Kyaw Thwai, Jean-Baptiste Mazarati, Jeffrey A. Bailey, Jonathan J. Juliano, Corine Karema   +10 more
doaj   +2 more sources

Resistance to Artemisinin Combination Therapies (ACTs): Do Not Forget the Partner Drug!

Tropical Medicine and Infectious Disease, 2019
Artemisinin-based combination therapies (ACTs) have become the mainstay for malaria treatment in almost all malaria endemic settings. Artemisinin derivatives are highly potent and fast acting antimalarials; but they have a short half-life and need to be ...
Christian Nsanzabana
doaj   +3 more sources

The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background [PDF]

Nature Communications, 2018
Mechanisms underlying increasing artemisinin resistance of Plasmodium in Southeast Asia remain unclear. Here, Zhu et al. integrate TWAS, GWAS and eQTL analyses for 773 P.
Lei Zhu, Jaishree Tripathi, Frances Maureen Rocamora, Olivo Miotto, Rob van der Pluijm, Till S. Voss, Sachel Mok, Dominic P. Kwiatkowski, François Nosten, Nicholas P. J. Day, Nicholas J. White, Arjen M. Dondorp, Zbynek Bozdech, Tracking Resistance to Artemisinin Collaboration I   +13 more
doaj   +2 more sources

A Temporizing Solution to “Artemisinin Resistance” [PDF]

New England Journal of Medicine, 2019
A Temporizing Solution to “Artemisinin Resistance” Three-day therapeutic courses are losing their efficacy against malarial parasites in the Greater Mekong Subregion. But continued rational and strategic use of artemisinin combination treatments is the best, and possibly the only, solution for the foreseeable future.
Chan, X-HS, White, NJ, Hien, TT
openaire   +5 more sources

Selection and spread of artemisinin-resistant alleles in Thailand prior to the global artemisinin resistance containment campaign. [PDF]

PLoS Pathogens, 2015
The recent emergence of artemisinin resistance in the Greater Mekong Subregion poses a major threat to the global effort to control malaria. Tracking the spread and evolution of artemisinin-resistant parasites is critical in aiding efforts to contain the
Eldin Talundzic, Sheila Akinyi Okoth, Kanungnit Congpuong, Mateusz M Plucinski, Lindsay Morton, Ira F Goldman, Patrick S Kachur, Chansuda Wongsrichanalai, Wichai Satimai, John W Barnwell, Venkatachalam Udhayakumar   +10 more
doaj   +1 more source

The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant Plasmodium falciparum

eLife, 2022
The effectiveness of artemisinin-based combination therapies (ACTs) to treat Plasmodium falciparum malaria is threatened by resistance. The complex interplay between sources of selective pressure—treatment properties, biological factors, transmission ...
Thiery Masserey, Tamsin Lee, Monica Golumbeanu, Andrew J Shattock, Sherrie L Kelly, Ian M Hastings, Melissa A Penny   +6 more
doaj   +1 more source

The Plasmodium falciparum artemisinin resistance-associated protein Kelch 13 is required for formation of normal cytostomes

bioRxiv, 2023
Artemisinin (ART) is a quick-killing and effective antimalarial activated by the haem derived from haemoglobin digestion. Mutations in the parasite’s Kelch 13 (K13) protein compromise the efficacy of this drug.
Madel V. Tutor, Gerald J. Shami, G. Siddiqui, D. Creek, Leann Tilley, Stuart A. Ralph   +5 more
semanticscholar   +1 more source

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

Communications Biology, 2022
The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions.
Lei Zhu, R. W. van der Pluijm, M. Kucharski, Sourav Nayak, Jaishree Tripathi, N. White, Nicholas P. J. Day, A. Faiz, A. P. Phyo, Chanaki Amaratunga, Dysoley Lek, E. Ashley, F. Nosten, F. Smithuis, H. Ginsburg, L. von Seidlein, K. Lin, M. Imwong, K. Chotivanich, M. Mayxay, M. Dhorda, Hoang Chau Nguyen, Thuy-Nhien Nguyen, Olivo Miotto, P. Newton, P. Jittamala, R. Tripura, S. Pukrittayakamee, T. Peto, H. Tran, A. Dondorp, Zbynek Bozdech   +31 more
semanticscholar   +1 more source

A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa

International Journal for Parasitology: Drugs and Drug Resistance, 2021
Artemisinin resistance (AR) emerged in South East Asia 13 years ago and the identification of the resistance conferring molecular marker, Plasmodium falciparum Kelch 13 (Pfk13), 7 years ago has provided an invaluable tool for monitoring AR in malaria ...
L. Ndwiga, K. Kimenyi, K. Wamae, Victor Osoti, M. Akinyi, Irene Omedo, D. Ishengoma, N. Duah-Quashie, B. Andagalu, A. Ghansah, A. Amambua-Ngwa, S. Tukwasibwe, S. Tessema, C. Karema, A. Djimdé, A. Dondorp, J. Raman, R. Snow, P. Bejon, L. Ochola-Oyier   +19 more
semanticscholar   +1 more source

Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance

Genome Biology, 2017
Background Artemisinin-based combination therapies are the first line of treatment for Plasmodium falciparum infections worldwide, but artemisinin resistance has risen rapidly in Southeast Asia over the past decade.
Gustavo C. Cerqueira, Ian H. Cheeseman, Steve F. Schaffner, Shalini Nair, Marina McDew-White, Aung Pyae Phyo, Elizabeth A. Ashley, Alexandre Melnikov, Peter Rogov, Bruce W. Birren, François Nosten, Timothy J. C. Anderson, Daniel E. Neafsey   +12 more
doaj   +1 more source