Results 11 to 20 of about 5,742,584 (242)

Spatio-temporal spread of artemisinin resistance in Southeast Asia. [PDF]

PLoS Computational Biology
Current malaria elimination targets must withstand a colossal challenge-resistance to the current gold standard antimalarial drug, namely artemisinin derivatives.
Jennifer A Flegg, Sevvandi Kandanaarachchi, Philippe J Guerin, Arjen M Dondorp, Francois H Nosten, Sabina Dahlström Otienoburu, Nick Golding   +6 more
doaj   +5 more sources

Artemisinin resistance, some facts and opinions [PDF]

Journal of Infection in Developing Countries, 2015
Resistance to artemisinin derivatives (ARTs) in malaria disease is currently defined as a delayed parasite clearance following artemisinin combined therapy (ACT).
Antonella Pantaleo, Maria Carmina Pau, Huynh Dinh Chien, Francesco Turrini   +3 more
doaj   +9 more sources

Artemisinin Resistance in Plasmodium falciparum Malaria [PDF]

New England Journal of Medicine, 2009
BACKGROUND Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.
A. Dondorp, F. Nosten, P. Yi, D. Das, Aung P. Phyo, J. Tarning, K. Lwin, F. Ariey, W. Hanpithakpong, Sue J. Lee, P. Ringwald, K. Silamut, M. Imwong, K. Chotivanich, Pharath Lim, T. Herdman, S. An, S. Yeung, P. Singhasivanon, N. Day, N. Lindegårdh, Socheat Duong, N. White   +22 more
semanticscholar   +3 more sources

Parasite proteostasis and artemisinin resistance

Research Square, 2023
The continued emergence and spread of resistance to artemisinins, the cornerstone of first line antimalarials, threatens significant gains made toward malaria elimination.
M. Rosenthal, Caroline L. Ng
semanticscholar   +3 more sources

Identification of Co-Existing Mutations and Gene Expression Trends Associated With K13-Mediated Artemisinin Resistance in Plasmodium falciparum

Frontiers in Genetics, 2022
Plasmodium falciparum infects millions and kills thousands of people annually the world over. With the emergence of artemisinin and/or multidrug resistant strains of the pathogen, it has become even more challenging to control and eliminate the disease ...
Mukul Rawat, Abhishek Kanyal, Deepak Choubey, Bhagyashree Deshmukh, Rashim Malhotra, DV Mamatharani, Anjani Gopal Rao, Krishanpal Karmodiya   +7 more
doaj   +2 more sources

Inaccurate communication in health sciences: The case of ‘partial artemisinin resistance’ for the treatment of malaria [PDF]

New Microbes and New Infections
Background: Accurate scientific terminology is crucial in health sciences to avoid misinterpretations. The use of ‘artemisinin resistance’ to describe delayed parasite clearance may be inaccurately equated with full resistance, as is typically the case ...
T. Hanscheid, Sara M. Mahomed, Maria Rebelo, Susana Oliveira Henriques, Martin P. Grobusch   +4 more
doaj   +2 more sources

tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum. [PDF]

Nat Microbiol
Plasmodium falciparum artemisinin (ART) resistance is driven by mutations in kelch-like protein 13 (PfK13). Quiescence, a key aspect of resistance, may also be regulated by a yet unidentified epigenetic pathway.
Small-Saunders JL, Sinha A, Bloxham TS, Hagenah LM, Sun G, Preiser PR, Dedon PC, Fidock DA.   +7 more
europepmc   +2 more sources

Lumefantrine attenuates Plasmodium falciparum artemisinin resistance during the early ring stage

International Journal for Parasitology: Drugs and Drug Resistance, 2021
Emerging artemisinin resistance in Plasmodium falciparum malaria has the potential to become a global public health crisis. In Southeast Asia, this phenomenon clinically manifests in the form of delayed parasite clearance following artemisinin treatment.
Krittikorn Kümpornsin, Duangkamon Loesbanluechai, Cristina de Cozar, Namfon Kotanan, Kesinee Chotivanich, Nicholas J. White, Prapon Wilairat, Maria G. Gomez-Lorenzo, Francisco Javier Gamo, Laura Maria Sanz, Marcus C.S. Lee, Thanat Chookajorn   +11 more
doaj   +2 more sources

New insights into the spread of resistance to artemisinin and its analogues

Journal of Global Antimicrobial Resistance, 2021
: Plasmodium falciparum, the causative agent of malaria, has been developing resistance to several drugs worldwide for more than five decades. Initially, resistance was against drugs such as chloroquine, pyrimethamine, sulfadoxine, mefloquine and quinine.
Noreen Noreen, Asad Ullah, Syed Muhammad Salman, Yahia Mabkhot, Abdulrhman Alsayari, Syed Lal Badshah   +5 more
doaj   +3 more sources

Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background. [PDF]

Nat Commun
The emergence of Plasmodium falciparum parasites resistant to artemisinins compromises the efficacy of Artemisinin Combination Therapies (ACTs), the global first-line malaria treatment.
Nayak S, Peto TJ, Kucharski M, Tripura R, Callery JJ, Quang Huy DT, Gendrot M, Lek D, Nghia HDT, van der Pluijm RW, Dong N, Long LT, Vongpromek R, Rekol H, Hoang Chau N, Miotto O, Mukaka M, Dhorda M, von Seidlein L, Imwong M, Roca X, Day NPJ, White NJ, Dondorp AM, Bozdech Z.   +24 more
europepmc   +2 more sources