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Potential Applications of Artemisinins in Ocular Diseases [PDF]
International Journal of Ophthalmology, 2019 Artemisinin, also named qinghaosu, is a family of sesquiterpene trioxane lactone originally derived from the sweet wormwood plant (Artemisia annua), which is a traditional Chinese herb that has been universally used as anti-malarial agents for many years.
Bing-Wen Lu, Li-Ke Xie
exaly +4 more sources
Postgraduate Medical Journal, 2005 Abstract Artemisinins were discovered to be highly effective antimalarial drugs shortly after the isolation of the parent artemisinin in 1971 in China. These compounds combine potent, rapid antimalarial activity with a wide therapeutic index and an absence of clinically important resistance.
Woodrow, CJ, Haynes, RK, Krishna, S.
openaire +5 more sources
The contrasting effects of two antimalarial drugs on insulin secretion [PDF]
Cellular and Molecular Life SciencesQuinolines and artemisinins are the two most important antimalarial drugs worldwide. In addition to antimalarial effects, quinine has been extensively documented to directly stimulate insulin secretion, potentially causing hypoglycemia in malaria ...
Jing Lu +6 more
doaj +2 more sources
ER Stress Induced by Artemisinin and Its Derivatives Determines the Susceptibility to Their Synergistic Apoptotic Killing With TRAIL [PDF]
Cancer MedicineAim Artemisinins are a class of antimalarial drugs that are lately being researched for their antitumor activity. We previously reported that artesunate, an artemisinin derivative, can induce ferroptosis and enhance TRAIL (Tumor necrosis factor‐Related ...
Snigdha Bhowmick, Yong J. Lee
doaj +2 more sources
4-Aminoquinolines block heme iron reactivity and interfere with artemisinin action [PDF]
eLifeArtemisinin-based combination therapies (ACTs) remain the mainstay of treatment for Plasmodium falciparum malaria, despite reports of ACT treatment failure. ACTs consist of an artemisinin and a longer-lived partner drug, which is often a quinoline. Given
Melissa Rosenthal, Daniel E Goldberg
doaj +2 more sources
Artemisinin-resistant malaria. [PDF]
Clin Microbiol RevSUMMARY The artemisinin antimalarials are the cornerstone of current malaria treatment. The development of artemisinin resistance in Plasmodium falciparum poses a major threat to malaria control and elimination.
White NJ, Chotivanich K.
europepmc +4 more sources
Chemie in unserer Zeit, 2014 AbstractArtemisinin ist der modernste Wirkstoff gegen Malaria, eine Infektionskrankheit, die den Menschen durch seine gesamte Entwicklungsgeschichte begleitete. Experimentelle Hinweise auf antike Malaria‐Epidemien gelangen durch Vervielfältigung von DNA‐Fragmenten des Erregers mit Hilfe der Polymerasekettenreaktion und dem Abgleich mit dem inzwischen ...
Paul May, Simon Cotton
+7 more sources
Molecules, 2022 The rich source of heme within malarial parasites has been considered to underly the action specificity of artemisinin. We reasoned that increasing intraparasitic free heme levels might further sensitize the parasites to artemisinin.
Pan Zhu, Bing Zhou
doaj +1 more source
Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics
Acta Pharmaceutica Sinica B, 2021 Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed world. Despite considerable research, few therapies have proven effective and been approved clinically for treatment of fibrosis.
David Dolivo +2 more
openaire +3 more sources
Artemether treatment improves islet function and metabolic homeostasis in diabetic nonhuman primates
Journal of Diabetes, 2023 Highlights Artemether increased the serum concentration of c‐peptide and decreased the usage of insulin in the diabetic monkey. Artemether downregulated the serum concentration of total cholesterol and low‐density lipoprotein cholesterol in the diabetic ...
Wei Fu, Jiang Hongwei, Jin Li
doaj +1 more source