Artemisinins inhibit oral candidiasis caused by Candida albicans through the repression on its hyphal development [PDF]
International Journal of Oral Science, 2023 Candida albicans is the most abundant fungal species in oral cavity. As a smart opportunistic pathogen, it increases the virulence by switching its forms from yeasts to hyphae and becomes the major pathogenic agent for oral candidiasis.
Xiaoyue Liang +12 more
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ER Stress Induced by Artemisinin and Its Derivatives Determines the Susceptibility to Their Synergistic Apoptotic Killing With TRAIL [PDF]
Cancer MedicineAim Artemisinins are a class of antimalarial drugs that are lately being researched for their antitumor activity. We previously reported that artesunate, an artemisinin derivative, can induce ferroptosis and enhance TRAIL (Tumor necrosis factor‐Related ...
Snigdha Bhowmick, Yong J. Lee
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Potential applications of artemisinins in ocular diseases [PDF]
International Journal of Ophthalmology, 2019 Artemisinin, also named qinghaosu, is a family of sesquiterpene trioxane lactone originally derived from the sweet wormwood plant (Artemisia annua), which is a traditional Chinese herb that has been universally used as anti-malarial agents for many years.
Bing-Wen Lu, Li-Ke Xie
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The contrasting effects of two antimalarial drugs on insulin secretion [PDF]
Cellular and Molecular Life SciencesQuinolines and artemisinins are the two most important antimalarial drugs worldwide. In addition to antimalarial effects, quinine has been extensively documented to directly stimulate insulin secretion, potentially causing hypoglycemia in malaria ...
Jing Lu +6 more
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Frontiers in Pharmacology, 2020 Artemisinin and its derivatives have shown broad-spectrum antitumor activities in vitro and in vivo. Furthermore, outcomes from a limited number of clinical trials provide encouraging evidence for their excellent antitumor activities.
Xiaoping Yang
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4-Aminoquinolines block heme iron reactivity and interfere with artemisinin action [PDF]
eLifeArtemisinin-based combination therapies (ACTs) remain the mainstay of treatment for Plasmodium falciparum malaria, despite reports of ACT treatment failure. ACTs consist of an artemisinin and a longer-lived partner drug, which is often a quinoline. Given
Melissa Rosenthal, Daniel E Goldberg
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Recent Progresses in Cancer Nanotherapeutics Design Using Artemisinins as Free Radical Precursors
Frontiers in Chemistry, 2020 Artemisinin and its derivatives (ARTs) are sort of important antimalarials, which exhibit a wide range of biological activities including anticancer effect.
Zhiwen Qi, Fang Liu
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Artemisinin-resistant malaria. [PDF]
Clin Microbiol RevSUMMARY The artemisinin antimalarials are the cornerstone of current malaria treatment. The development of artemisinin resistance in Plasmodium falciparum poses a major threat to malaria control and elimination.
White NJ, Chotivanich K.
europepmc +4 more sources
Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background [PDF]
Nature CommunicationsThe emergence of Plasmodium falciparum parasites resistant to artemisinins compromises the efficacy of Artemisinin Combination Therapies (ACTs), the global first-line malaria treatment.
Sourav Nayak +24 more
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Chemie in unserer Zeit, 2014 AbstractArtemisinin ist der modernste Wirkstoff gegen Malaria, eine Infektionskrankheit, die den Menschen durch seine gesamte Entwicklungsgeschichte begleitete. Experimentelle Hinweise auf antike Malaria‐Epidemien gelangen durch Vervielfältigung von DNA‐Fragmenten des Erregers mit Hilfe der Polymerasekettenreaktion und dem Abgleich mit dem inzwischen ...
Paul May, Simon Cotton
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