Results 31 to 40 of about 6,373 (213)

Recent Progresses in Cancer Nanotherapeutics Design Using Artemisinins as Free Radical Precursors

Frontiers in Chemistry, 2020
Artemisinin and its derivatives (ARTs) are sort of important antimalarials, which exhibit a wide range of biological activities including anticancer effect.
Yalan Wu, Yalan Wu, Qingping Zeng, Zhiwen Qi, Tao Deng, Fang Liu   +5 more
doaj   +1 more source

Expanding the Chemical Space of Analytes in the 2G Crystalline Sponge Method: Size‐Compensation Strategy for the Structural Analysis of Low‐Polarity Small Molecules

Angewandte Chemie, EarlyView.
The accessible chemical space of second‐generation crystalline sponges (2G‐CSs) is extended to low‐polarity small molecules via a modulator‐enabled strategy. The key is the size compensation between guest and modulator to achieve a snug fit within the cage cavity.
Wei He, Luc Soliman, Hiroki Takezawa, Makoto Fujita   +3 more
wiley   +2 more sources

Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities

Molecules, 2018
According to the precepts that C-10 amino-artemisinins display optimum biological activities for the artemisinin drug class, and that attachment of a sugar enhances specificity of drug delivery, polarity and solubility so as to attenuate toxicity, we ...
Yuet Wu, Silvia Parapini, Ian D. Williams, Paola Misiano, Ho Ning Wong, Donatella Taramelli, Nicoletta Basilico, Richard K. Haynes   +7 more
doaj   +1 more source

Special Issue “Artemisinin (Qinghaosu): Commemorative Issue in Honor of Professor Youyou Tu on the Occasion of Her 80th Anniversary” in International Molecules Published in 2010

Molecules, 2021
It has been more than 10 years since we published the Special Issue “Artemisinin (Qinghaosu): commemorative issue in honor of Professor Youyou Tu on the occasion of her 80th anniversary” (Abbreviated as “the Artemisinins Special Issue”) [...]
Yan He, Shu-Kun Lin
doaj   +1 more source

Capacity Development through the US President’s Malaria Initiative–Supported Antimalarial Resistance Monitoring in Africa Network

Emerging Infectious Diseases, 2017
Antimalarial drug resistance is an evolving global health security threat to malaria control. Early detection of Plasmodium falciparum resistance through therapeutic efficacy studies and associated genetic analyses may facilitate timely implementation of
Eric S. Halsey, Meera Venkatesan, Mateusz M. Plucinski, Eldin Talundzic, Naomi W. Lucchi, Zhiyong Zhou, Celine I. Mandara, Hawela Moonga, Busiku Hamainza, Abdoul Habib Beavogui, Simon Kariuki, Aaron M. Samuels, Laura C. Steinhardt, Don P. Mathanga, Julie Gutman, Yves Eric Denon, Aline Uwimana, Ashenafi Assefa, Jimee Hwang, Ya Ping Shi, Pedro Rafael Dimbu, Ousmane Koita, Deus S. Ishengoma, Daouda Ndiaye, Venkatachalam Udhayakumar   +24 more
doaj   +1 more source

Design and De Novo Synthesis of 6‑Aza-artemisinins

, 2018
Development of designer natural product variants, 6-aza-artemisinins, enabled us to achieve structural modification of the hitherto unexplored cyclohexane moiety of artemisinin and concise de novo synthesis of the tetracyclic scaffold in just four steps ...
Satoshi O̅mura (1577326), Kazuhiko Otoguro (1652044), Hideaki Oikawa (822472), Kyohei Ochiai (5116853), Takahisa Hiruma (2201287), Shun Suzuki (5545832), Rei Hokari (2862743), Masato Iwatsuki (1652047), Hiroki Oguri (1843054), Karunakar Reddy Bonepally (5545829), Haruki Mizoguchi (1322250), Aki Ishiyama (1652050)   +11 more
core   +1 more source

Making artemisinin☆

Phytochemistry, 2008
The possibilities for the production of the antimalarial artemisinin by biological and chemical means are explored. These include native biosynthesis, genetic modification of Artemisia annua and other plants, engineering of microbes, total and partial chemical synthesis and combinations of the above.
openaire   +3 more sources

Dihydroartemisinin induces apoptosis in human bladder cancer cell lines through reactive oxygen species, mitochondrial membrane potential, and cytochrome C pathway

International Journal of Preventive Medicine, 2017
Background: Dihydroartemisinin (DHA) is a semisynthetic derivative of artemisinin and has antiproliferative effect. However, such effects of DHA have not yet been revealed for bladder cancer cells. Methods: We used as bladder cancer cell lines to examine
Farhad Poupel, Mahmoud Aghaei, Ahmad Movahedian, Seyyed Mehdi Jafari, Mohammad Keyvanloo Shahrestanaki   +4 more
doaj   +1 more source

Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance [PDF]

, 2006
There are more than half a billion cases of malaria every year. Combinations of an artemisinin with other antimalarial drugs are now recommended treatments for Plasmodium falciparum malaria in most endemic areas.
Staines, Henry M., Krishna, Sanjeev, Mercereau-Puijalon, O, Haynes, Richard K., Staines, HM, Woodrow, CJ, Krishna, S, Haynes, RK, Mercereau-Puijalon, Odile, Woodrow, Charles J.   +9 more
core   +1 more source

Methylene homologues of artemisone: an unexpected structure-activity relationship and a possible implication for the design of C10-substituted artemisinins [PDF]

, 2016
We sought to establish if methylene homologues of artemisone are biologically more active and more stable than artemisone. The analogy is drawn with the conversion of natural O- and N-glycosides into more stable C-glycosides that may possess enhanced ...
Krishna, Sanjeev, Haynes, Richard K., Wu, Ronald Wai Kung, Wu, Yuet, Williams, Ian D.   +4 more
core   +2 more sources