International Journal of Oral Science, 2023 Candida albicans is the most abundant fungal species in oral cavity. As a smart opportunistic pathogen, it increases the virulence by switching its forms from yeasts to hyphae and becomes the major pathogenic agent for oral candidiasis.
Xiaoyue Liang +12 more
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More than anti-malarial agents: therapeutic potential of artemisinins in neurodegeneration [PDF]
Neural Regeneration Research, 2019 Artemisinin, also called qinghaosu, is originally derived from the sweet wormwood plant (Artemisia annua), which is used in traditional Chinese medicine. Artemisinin and its derivatives (artemisinins) have been widely used for many years as anti-malarial
Bing-Wen Lu +4 more
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Safety, pharmacokinetics and efficacy of artemisinins in pregnancy [PDF]
Infectious Disease Reports, 2011 Malaria in pregnancy can lead to serious maternal and fetal morbidity and mortality. Access to the most effective antimalarials in pregnancy is essential.
Veronica Ades
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Artemether resistance
Malaria Journal, 2012 Background Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins. Methods Plasmodium falciparum
Pillai Dylan R +6 more
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Biological Actions of Artemisinin: Insights from Medicinal Chemistry Studies
Molecules, 2010 Artemisinins have become essential antimalarial drugs for increasingly widespread drug-resistant malaria strains. Although tremendous efforts have been devoted to decipher how this class of molecules works, their exact antimalarial mechanism is still an ...
Jian Li, Bing Zhou
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Profiling of the anti-malarial drug candidate SC83288 against artemisinins in Plasmodium falciparum [PDF]
Malaria Journal, 2018 Background The increased resistance of the human malaria parasite Plasmodium falciparum to currently employed drugs creates an urgent call for novel anti-malarial drugs.
Maëlle Duffey +2 more
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Selective Inhibition of Plasmodium falciparum ATPase 6 by Artemisinins and Identification of New Classes of Inhibitors after Expression in Yeast [PDF]
, 2022 Treatment failures with artemisinin combination therapies (ACTs) threaten global efforts to eradicate malaria. They highlight the importance of identifying drug targets and new inhibitors and of studying how existing antimalarial classes work.
Krishna, Sanjeev +7 more
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Preprint: Selective inhibition of PfATP6 by artemisinins and identification of new classes of inhibitors after expression in yeast [PDF]
, 2021 Treatment failures with artemisinin combination therapies (ACTs) threaten global efforts to eradicate malaria. They highlight the importance of identifying drug targets and new inhibitors and of studying how existing antimalarial classes work. Herein we
Sanjeev Krishna +16 more
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Antimicrobial Agents and Chemotherapy, 2003 A recent Letter to the Editor (R. K. Haynes, D. Monti, D. Taramelli, N. Basilico, S. Parapini, and P. Olliaro, Letter, Antimicrob. Agents Chemother. 47:1175, 2003) presented cogent evidence that artemisinin and its derivatives do not inhibit hemozoin formation in vitro.
Haynes, Richard K. +5 more
openaire +5 more sources
Evidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugs. [PDF]
PLoS ONE, 2012 Plasmodium falciparum malaria is a major global health problem, causing approximately 780,000 deaths each year. In response to the spreading of P. falciparum drug resistance, WHO recommended in 2001 to use artemisinin derivatives in combination with a ...
Benoit Witkowski +8 more
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