Results 41 to 50 of about 5,305 (182)
In Vitro and In Silico Antimalarial Evaluation of FM-AZ, a New Artemisinin Derivative
Medicines, 2022 Artemisinin-based Combination Therapies (ACTs) are currently the frontline treatment against Plasmodium falciparum malaria, but parasite resistance to artemisinin (ART) and its derivatives, core components of ACTs, is spreading in the Mekong countries ...
Ioannis Tsamesidis +7 more
doaj +1 more source
Truncation of Samroiyotmycin: Tailored seco‐Acids as Novel Antimalaria Compounds
European Journal of Organic Chemistry, EarlyView.Six truncated samroiyotmycin‐derived antimalarials were synthesized by replacing the tosyloxazole unit with electron‐deficient aryl groups. The most active seco‐acid with EWG = 2 × CF3 outperformed the natural product SamA. Its enhanced activity supports a donor–acceptor interaction involving the electron‐poor aryl unit, consistent with inhibition of ...
Anton Czuczkowski +10 more
wiley +1 more source
Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target. [PDF]
PLoS ONE, 2009 Heme (Fe2+ protoporphyrin IX) is an essential molecule that has been implicated the potent antimalarial action of artemisinin and its derivatives, although the source and nature of the heme remain controversial.
Shiming Zhang, Glenn S Gerhard
doaj +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider +3 more
wiley +1 more source
Biological Actions of Artemisinin: Insights from Medicinal Chemistry Studies
Molecules, 2010 Artemisinins have become essential antimalarial drugs for increasingly widespread drug-resistant malaria strains. Although tremendous efforts have been devoted to decipher how this class of molecules works, their exact antimalarial mechanism is still an ...
Jian Li, Bing Zhou
doaj +1 more source
Hybrid Gold(I) NHC-Artemether Complexes to Target Falciparum Malaria Parasites
Molecules, 2020 The emergence of Plasmodium falciparum parasites, responsible for malaria disease, resistant to antiplasmodial drugs including the artemisinins, represents a major threat to public health.
Manel Ouji +6 more
doaj +1 more source
Applicability of Redirecting Artemisinins for New Targets
Global Challenges, 2023 Employing new therapeutic indications for drugs that are already approved for human use has obvious advantages, including reduced costs and timelines, because some routine steps of drug development and regulation are not required.
Jacob Golenser +6 more
doaj +1 more source
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine
Engineering, 2019 Artemisinin and its derivatives represent the most important and influential class of drugs in the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global community has made great strides in characterizing and ...
Jigang Wang +6 more
doaj +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source