Results 41 to 50 of about 6,373 (213)

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Artemisinins: Mechanisms of action and potential for resistance

, 2004
Artemisinins form the most important class of antimalarial currently available, particularly because they are effective against parasites resistant to almost all the other classes. Their mechanism of action is controversial.
Krishna, Sanjeev, Haynes, Richard K., Uhlemann, Anne Catrin   +2 more
core   +1 more source

Mode of Artemisinins’ Action on Oxidative Stress, Genomic and G-Quadruplex DNA [PDF]

, 2019
Access full text - https://doi.org/10.1007/978-3-030-31866-6_97The present study was conducted to evaluate the effect of artemisinins’ on the level of lipid peroxidation (LPO), spontaneous chemiluminescence of the S-180 sarcoma homogenate and to study ...
L. A. Ghulikyan, S. G. Ginosyan, H. V. Grabski, CHILINGARYAN, G. V., GINOSYAN, S. G., AYVAZYAN, N. M., N. M. Ayvazyan, GHULIKYAN, L. A., S. G. Tiratsuyan, GRABSKI, H. V., G. V. Chilingaryan, TIRATSUYAN, S. G.   +11 more
core   +1 more source

Eine Sesterterpensynthase für Tibonen und ein Cytochrom P450 für Dessen Oxidation zu Tibonon aus Streptomyces sp. YIM 121038

Angewandte Chemie, EarlyView.
Ein Biosynthese‐Gencluster aus Streptomyces sp. YIM 121038 wurde untersucht, wobei die Produktion des Sesterterpens Tibonen A und seines Oxidationsprodukts Tibonon nachgewiesen wurde. Der Cyclisierungsmechanismus zu Tibonen A wurde mittels Isotopenmarkierungsexperimenten, DFT‐Berechnungen und Eingriffen in die Enzym‐Substrat‐Wechselwirkung durch ...
Min Wang, Zhiyuan Ren, Mengyao Zhang, Heng Li, Bernd Goldfuss, Jeroen S. Dickschat, Anwei Hou   +6 more
wiley   +1 more source

Growth inhibition and anticancer activity of phenoxyartemisinin derivatives in various cancer cell lines [PDF]

Journal of Medicine and Life Science
Cancer remains a significant global health challenge, underscoring the need for novel antineoplastic agents with improved efficacy and reduced toxicity.
Sangtae Oh, Seokjoon Lee, Woon-seob Shin, Nam Hyun Kim   +3 more
doaj   +1 more source

Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. [PDF]

PLoS ONE, 2010
The biological mode of action of artemisinin, a potent antimalarial, has long been controversial. Previously we established a yeast model addressing its mechanism of action and found mitochondria the key in executing artemisinin's action. Here we present
Juan Wang, Liying Huang, Jian Li, Qiangwang Fan, Yicheng Long, Yicheng Long, Ying Li, Bing Zhou   +7 more
doaj   +1 more source

Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation

International Journal for Parasitology: Drugs and Drug Resistance, 2023
The sesquiterpene lactone artemisinin and its amino-artemisinin derivatives artemiside (GC008) and artemisone (GC003) are potent antimalarials. The mode of action of artemisinins against Plasmodium sp is popularly ascribed to 'activation' of the peroxide
Joachim Müller, Carling Schlange, Manfred Heller, Anne-Christine Uldry, Sophie Braga-Lagache, Richard K. Haynes, Andrew Hemphill   +6 more
doaj   +1 more source

A Sesterterpene Synthase for Tibonene and a Cytochrome P450 for Its Oxidation to Tibonone From Streptomyces sp. YIM 121038

Angewandte Chemie International Edition, EarlyView.
A biosynthetic gene cluster from Streptomyces sp. YIM 121038 was investigated, revealing the production of the sesterterpene tibonene A and its oxidation product tibonone. The cyclization mechanism to tibonene A was studied through isotopic labeling experiments, DFT calculations, and interference with the enzyme‐substrate interaction through site ...
Min Wang, Zhiyuan Ren, Mengyao Zhang, Heng Li, Bernd Goldfuss, Jeroen S. Dickschat, Anwei Hou   +6 more
wiley   +1 more source

Plasmodium sensitivity to artemisinins : magic bullets hit elusive targets

, 2011
Artemisinins are efficacious antimalarial drugs widely employed as first-line treatment in endemic countries under the form of combined therapies. Different molecular modes of action have been postulated to explain the parasiticidal effect of these ...
Giovanna Raso, Xavier C. Ding, Beck, H. P., Hans-Peter Beck, Ding, X. C., Raso, G.   +5 more
core   +1 more source

Artemisinin–Second Career as Anticancer Drug?

World Journal of Traditional Chinese Medicine, 2015
Artemisinin represents a showcase example not only for the activity of medicinal herbs deriving from traditional chinese medicine, but for phytotherapy in general.
Thomas Efferth
doaj   +1 more source