Results 51 to 60 of about 6,373 (213)

In Vitro and In Silico Antimalarial Evaluation of FM-AZ, a New Artemisinin Derivative

Medicines, 2022
Artemisinin-based Combination Therapies (ACTs) are currently the frontline treatment against Plasmodium falciparum malaria, but parasite resistance to artemisinin (ART) and its derivatives, core components of ACTs, is spreading in the Mekong countries ...
Ioannis Tsamesidis, Farnoush Mousavizadeh, Chinedu O. Egwu, Dionysia Amanatidou, Antonella Pantaleo, Françoise Benoit-Vical, Karine Reybier, Athanassios Giannis   +7 more
doaj   +1 more source

Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target. [PDF]

PLoS ONE, 2009
Heme (Fe2+ protoporphyrin IX) is an essential molecule that has been implicated the potent antimalarial action of artemisinin and its derivatives, although the source and nature of the heme remain controversial.
Shiming Zhang, Glenn S Gerhard
doaj   +1 more source

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source

A single amino acid residue can determine the sensitivity of SERCAs to artemisinins

, 2005
Artemisinins are the most important class of antimalarial drugs. They specifically inhibit PfATP6, a SERCA-type ATPase of Plasmodium falciparum. Here we show that a single amino acid in transmembrane segment 3 of SERCAs can determine susceptibility to ...
Brady, L, Cameron, A, Zuniga, Felipe A., East, M, Fischbarg, J, Iserovich, P, East, Malcolm, Malcolm East, Eckstein-Ludwig, U, Iserovich, Pavel, Lee, A, Anne-Catrin Uhlemann, Jorge Fischbarg, Ursula Eckstein-Ludwig, Brady, Leo, Pavel Iserovich, Zuniga, FA, Cameron, Angus, Krishna, S, Eckstein-Ludwig, Ursula, Fischbarg, Jorge, Lee, Anthony, Uhlemann, Anne Catrin, Sanjeev Krishna, Leo Brady, Richard K Haynes, Krishna, Sanjeev, Haynes, Richard K., Uhlemann, A-C, Angus Cameron, Felipe A Zuniga, Anthony Lee, Haynes, RK   +32 more
core   +1 more source

The absence of women's scientific contributions in core UK pre‐university science qualifications

British Educational Research Journal, EarlyView.
Abstract Despite their groundbreaking contributions to our understanding of the natural world and the universe, women's roles in biology, chemistry, physics, astronomy, environmental science and geology remain largely absent from standard educational specifications in the United Kingdom (UK), particularly at Key Stage 4 (KS4) and Key Stage 5 (KS5), or ...
G. J. Cooke, S. B. White, S. Buttigieg, N. Lowson, S. Galaudage, A. Battisti, L. Kelsey, K. Ross   +7 more
wiley   +1 more source

Hybrid Gold(I) NHC-Artemether Complexes to Target Falciparum Malaria Parasites

Molecules, 2020
The emergence of Plasmodium falciparum parasites, responsible for malaria disease, resistant to antiplasmodial drugs including the artemisinins, represents a major threat to public health.
Manel Ouji, Guillaume Barnoin, Álvaro Fernández Álvarez, Jean-Michel Augereau, Catherine Hemmert, Françoise Benoit-Vical, Heinz Gornitzka   +6 more
doaj   +1 more source

Applicability of Redirecting Artemisinins for New Targets

Global Challenges, 2023
Employing new therapeutic indications for drugs that are already approved for human use has obvious advantages, including reduced costs and timelines, because some routine steps of drug development and regulation are not required.
Jacob Golenser, Nicholas H. Hunt, Ida Birman, Charles L. Jaffe, Johanna Zech, Karsten Mäder, Daniel Gold   +6 more
doaj   +1 more source

Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine

Engineering, 2019
Artemisinin and its derivatives represent the most important and influential class of drugs in the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global community has made great strides in characterizing and ...
Jigang Wang, Chengchao Xu, Yin Kwan Wong, Yujie Li, Fulong Liao, Tingliang Jiang, Youyou Tu   +6 more
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Letter to Nature. Artemisinins target the SERCA of plasmodium falciparum

, 2003
Artemisinins are extracted from sweet wormwood (Artemisia annua) and are the most potent antimalarials available1, rapidly killing all asexual stages of Plasmodium falciparum2.
U. Eckstein-Ludwig, Lee, A.G., Bray, P.G., Van Goethem, I. D.A., R. J. Webb, S. A. Ward, P. M. O'Neill, Ward, S.A., Ward, Steve, East, J.M., O'Neill, P.M., Webb, R. J., A. G. Lee, M. Kimura, Bray, P. G., S. Krishna, East, J. M., Lee, A. G., I. D. A. van Goethem, Kimura, M., Webb, R.J., Krishna, S., J. M. East, Eckstein-Ludwig, U., O'Neill, P. M., van Goethem, I.D.A, P. G. Bray   +26 more
core   +1 more source