Results 71 to 80 of about 6,373 (213)

Dihydroartemisinin Engages NQO1 and Promotes Ferroptosis‐Related Oxidative Stress in Non‐Small Cell Lung Cancer

Phytotherapy Research, EarlyView.
Dihydroartemisinin Engages NQO1 and Promotes Ferroptosis‐Related Oxidative Stress in Non‐Small Cell Lung Cancer. ABSTRACT Dihydroartemisinin (DHA), a bioactive derivative of Artemisia annua L. (AAL), has shown antitumor activity in several malignancies, including non‐small cell lung cancer (NSCLC).
Xiuli Guo, Gan Tao, Mini Zhang, Linzhi Han, Sisi Yan, Chunsheng Wang, Jianguo Zhang, Xiaowan Guo, Kehua Hu, Yan Gong, Qiuji Wu, Conghua Xie   +11 more
wiley   +1 more source

The case for development of 11-aza-artemisinins for malaria

, 2015
The current treatment regimens for uncomplicated malaria comprise an artemisinin in combination with another drug (ACT). However, the recent emergence of resistance to ACTs in South East Asia dramatically emphasizes the need for new artemisinins.
Smit, Frans, Wong, Ho Ning, Haynes, Richard, N'Da, David D., Harmse, Rozanne, Haynes, Richard K.   +5 more
core   +1 more source

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins [PDF]

, 2016
Current first-line artemisinin antimalarials are threatened by the emergence of resistant Plasmodium falciparum. Decreased sensitivity is evident in the initial (early ring) stage of intraerythrocytic development, meaning that it is crucial to understand
Yang, Tuo, Tilley, Leann, Charman, Susan, Batinovic, Steven, Dogovski, Con, Teguh, Silvia, Crespo, Maria P., Stafford, Che, Klonis, Nectarios, Chiu, Francis, Hanssen, Eric, Xie, Stanley C.; id_orcid   +11 more
core   +1 more source

4′‐Hydroxywogonin Attenuates Hepatocellular Carcinoma Progression by Suppressing Gas6/Axl‐PI3K/AKT Signaling

Phytotherapy Research, EarlyView.
4′‐Hydroxywogonin, a flavonoid derived from Scutellaria baicalensis, inhibits hepatocellular carcinoma progression partly by suppressing Gas6/Axl‐PI3K/AKT signaling, inducing cell cycle arrest and apoptosis, and reducing metastatic potential. It also suppresses xenograft tumor growth without evident hepatotoxicity.
Chi‐Yuan Chen, Chin‐Chuan Chen, Chau‐Ting Yeh, Chieh‐Wen Chan, Yu‐De Chu, Yann‐Lii Leu, Roshan B. Satange, Li‐Fang Chou, Wen‐Yu Chuang, Chuen Hsueh, Tzong‐Ming Shieh, Tong‐Hong Wang   +11 more
wiley   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

“The Smell Makes Us Hungry”: When Food Is Not Medicine in Highland Madagascar

Culture, Agriculture, Food and Environment, EarlyView.
ABSTRACT In the wake of major disruptions to global supply chains during the Covid‐19 pandemic, the island nation of Madagascar pursued initiatives for auto‐suffisance, self‐sufficiency, in food supplies and medical treatments. Farming communities in the central highlands experienced an injunction to expand cultivation of both subsistence crops and ...
Gabrielle Robbins
wiley   +1 more source

Artemisinin

HIMALAYA, 2019
Malaria is a disease that has blighted humankind since early times. The first antimalarial treatment available to Europeans was the dried bark of the cinchona tree from Peru. The main problem in its use was adulteration by other material. The ‘active principle’ was first extracted in 1820 and named quinine.
openaire   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Nutrient Sensing and Growth Control in Plasmodium: Beyond mTOR Signaling

Molecular Microbiology, EarlyView.
Plasmodium parasites lack the canonical mTOR kinase and associated signaling complexes, yet retain key mTOR‐like functions. Parasite‐specific nutrient sensors, kinases, and translational regulators coordinate growth, stress adaptation, metabolic plasticity, and developmental decisions through a distributed regulatory network.
Felix Müller, Gabriele Pradel
wiley   +1 more source

Molecular screening for <i>Plasmodium falciparum</i> resistance markers for artemisinins in Mbita, Kenya [PDF]

, 2011
Artemisinins-based combination therapies (ACTs) are being recommended against uncomplicated malaria in endemic areas of Africa. However, in these areas data on their long term usefulness is limited.
Omar, S, FT Kimani, Wangai, LN, Kimani, FT, Maina, N, M Geoffrey, G Magoma, Geoffrey, M, MW Burugu, Mwangi, JM, S Omar, Magoma, G, LN Wangai, N Maina, JM Mwangi, Burugu, MW   +15 more
core   +1 more source