Results 61 to 70 of about 6,373 (213)
A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors
EMBO Molecular Medicine, 2023 The natural compound Artemisinin is the most widely used antimalarial drug worldwide. Based on its cytotoxicity, it is also used for anticancer therapy.
Jasmin Taubenschmid‐Stowers +21 more
doaj +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li +6 more
wiley +1 more source
Neurotoxicity of Artemisinin Derivatives [PDF]
Clinical Infectious Diseases, 2006 tion to a recent letter published in this journal by Toovey [ 1 ] regarding the alleged neurotoxicity of the artemisinin derivatives. The letter was in response to a reply by Newton et al. [2] to a case reported by Franco-Paredes et al. [3]. This letter makes reference to our congress presentation [4], but Toovey has changed the title of our abstract ...
Adjei, George Obeng +2 more
openaire +3 more sources
Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy
Phytotherapy Research, EarlyView.This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi +9 more
wiley +1 more source
Phytotherapy Research, EarlyView.This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren +10 more
wiley +1 more source
Artemisinin anti-malarial drugs in China
Acta Pharmaceutica Sinica B, 2016 Discovered by Youyou Tu, one of the 2015 Nobel Prize winners in Physiology or Medicine, together with many other Chinese scientists, artemisinin, artemether and artesunate, as well as other artemisinins, have brought the global anti-malarial treatment to
Zongru Guo
doaj +1 more source
Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine
Phytotherapy Research, EarlyView.By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao +11 more
wiley +1 more source
Parasite, 2018 The use of artemisinin-based combination therapies (ACTs), which combine an artemisinin derivative with a partner drug, in the treatment of uncomplicated malaria has largely been responsible for the significant reduction in malaria-related mortality in ...
Ouji Manel +3 more
doaj +1 more source
Phytotherapy Research, EarlyView.DHT directly binds to MIF and subsequently blunts AKT signaling, which restores the kinase activity of GSK‐3β. The reactivated GSK‐3β then promotes the phosphorylation (Ser33/37/Thr41) and proteasomal degradation of β‐catenin, thereby preventing its nuclear translocation and inhibiting the transcription of EMT‐related genes (e.g., Snail and Twist ...
Chuhang Wang +10 more
wiley +1 more source
Molecules, 2009 Preclinical studies in rodents have demonstrated that artemisinins, especially injectable artesunate, can induce fetal death and congenital malformations at a low dose range.
Qigui Li, Peter J. Weina
doaj +1 more source