Results 21 to 30 of about 5,742,584 (242)

Artemisinin resistance in Plasmodium falciparum [PDF]

The Lancet Infectious Diseases, 2014
Artemisinin resistance in Plasmodium falciparum is observed in young (0-3 h) ring-stage parasites, which have a high parasite survival rate in the in-vitro ring-stage survival assay (RSA0-3h), but then become susceptible as they mature to late rings in the RSA9-12h and early trophozoites in the TSA18-21h.
Chanaki, Amaratunga, Benoit, Witkowski, Nimol, Khim, Didier, Menard, Rick M, Fairhurst   +4 more
core   +7 more sources

The newly discovered role of endocytosis in artemisinin resistance

Medicinal Research Reviews, 2021
Artemisinin and its derivatives (ART) are the cornerstone of malaria treatment as part of artemisinin combination therapy (ACT). However, reduced susceptibility to artemisinin as well as its partner drugs threatens the usefulness of ACTs.
Tobias Spielmann, Sabine Schmidt, Hannah Michaela Behrens   +2 more
exaly   +2 more sources

Molecular profiling of the artemisinin resistance Kelch 13 gene in Plasmodium falciparum from Nigeria. [PDF]

PLoS One, 2022
Accurate assessment and monitoring of the Plasmodium falciparum Kelch 13 (pfk13) gene associated with artemisinin resistance is critical to understand the emergence and spread of drug-resistant parasites in malaria-endemic regions.
Ajogbasile FV, Oluniyi PE, Kayode AT, Akano KO, Adegboyega BB, Philip C, Ogbulafor N, Okafor HU, Oguche S, Wammanda RD, Mokuolu OA, Folarin OA, Happi CT.   +12 more
europepmc   +2 more sources

Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum. [PDF]

Malar J, 2021
The devastating public health impact of malaria has prompted the need for effective interventions. Malaria control gained traction after the introduction of artemisinin-based combination therapy (ACT).
Owoloye A, Olufemi M, Idowu ET, Oyebola KM.   +3 more
europepmc   +2 more sources

Artemisinin Action and Resistance in Plasmodium falciparum [PDF]

Trends in Parasitology, 2016
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in recent years to a substantial reduction in deaths resulting from Plasmodium falciparum malaria. Resistance to artemisinins, however, has emerged in Southeast Asia. Clinically, resistance is defined as a slower rate of parasite clearance in patients treated with an ...
David Fidock, Leann Tilley, Nina Gnädig   +2 more
exaly   +3 more sources

Enhanced cell stress response and protein degradation capacity underlie artemisinin resistance in Plasmodium falciparum [PDF]

mSphere
Malaria remains a global health burden, killing over half a million people each year. Decreased therapeutic efficacy to artemisinin, the most efficacious antimalarial, has been detected in sub-Saharan Africa, a worrying fact given that over 90% of deaths
Melissa R. Rosenthal, Sukhithasri Vijayrajratnam, Tessa M. Firestone, Caroline L. Ng   +3 more
doaj   +2 more sources

Artemisinin resistance in Africa: How urgent is the threat? [PDF]

Med, 2021
SUMMARY Malaria is unrelenting in its impact on sub-Saharan Africa, with an estimated 215 million cases and 384,000 deaths in 2019, mostly in young children. Although devastating, this situation represents a halving in incidence and mortality compared to
Fidock DA, Rosenthal PJ.
europepmc   +2 more sources

Detection of Artemisinin Resistance Marker Kelch-13 469Y in Plasmodium falciparum, South Kivu, Democratic Republic of the Congo, 2022. [PDF]

Am J Trop Med Hyg
Partial artemisinin resistance has emerged in East Africa, posing a threat to malaria control across the continent. The Democratic Republic of the Congo carries one of the heaviest malaria burdens globally, and the South Kivu province directly borders ...
van Loon W, Bisimwa BC, Byela V, Kirby R, Bugeme PM, Balagizi A, Lupande D, Malembaka EB, Mockenhaupt FP, Bahizire E.   +9 more
europepmc   +2 more sources

Updates on k13 mutant alleles for artemisinin resistance in Plasmodium falciparum

Journal of Microbiology, Immunology and Infection, 2018
Background: In the fight against malaria caused by Plasmodium falciparum, the successes achieved by artemisinin were endangered by resistance of the parasites to the drug. Whole genome sequencing approach on artemisinin resistant parasite line discovered
Myo Thura Zaw, Nor Amalina Emran, Zaw Lin   +2 more
doaj   +3 more sources

Preventing antimalarial drug resistance with triple artemisinin-based combination therapies [PDF]

Nature Communications, 2023
Increasing levels of artemisinin and partner drug resistance threaten malaria control and elimination globally. Triple artemisinin-based combination therapies (TACTs) which combine artemisinin derivatives with two partner drugs are efficacious and well ...
Tran Dang Nguyen, Bo Gao, Chanaki Amaratunga, Mehul Dhorda, Thu Nguyen-Anh Tran, Nicholas J. White, Arjen M. Dondorp, Maciej F. Boni, Ricardo Aguas   +8 more
doaj   +2 more sources