Results 131 to 140 of about 5,742,584 (242)

Trichomes in Plant Defence, Development and Metabolic Integration Under Environmental Stress

Plant, Cell &Environment, EarlyView.
ABSTRACT Among various plant defence strategies, trichomes are tiny hair‐like structures on the epidermis that aid in defence, environmental adaptation and the production of valuable secondary metabolites. This review features trichomes as frontline guards for plant survival, integrating their structural, physiological and metabolic roles in ...
Debdatta Chatterjee, Madhabi Das, Sanjib Patra, Srijib Chatterjee, Amit Roy, Arunava Mandal   +5 more
wiley   +1 more source

Artemisinin resistance and stage dependency of parasite clearance in Falciparum malaria [PDF]

, 2019
Background Artemisinin resistance in falciparum malaria is associated with kelch13 propeller mutations, reduced ring stage parasite killing, and, consequently, slow parasite clearance.
Ashley, Elizabeth A., Dondorp, AM, Dhorda, M, Kingston, HW, Woodrow, C, Ashley, EA, Srinamon, K, Stepniewska, K, Dhorda, Mehul, Imwong, M, Silamut, K, Day, Nicholas P.J., White, NJ, Day, NPJ, Dondorp, Arjen M., White, Nicholas, Intharabut, B, Tracking Resistance To Artemisinin Collaboration   +17 more
core   +1 more source

Polymorphisms in the K13-Propeller Gene in Artemisinin-Resistant Plasmodium in Mice

Infection and Drug Resistance, 2022
Shaoqin Zheng1,2 *, Yuan Liang2 *, Zhaojia Wang,1 Min Liu,1 Yingyi Chen,1 Ying Ai,1 Wenfeng Guo,1,3 Guoming Li,1 Yueming Yuan,1,2 Zhiyong Xu,2 Wanting Wu,1 Xinan Huang,1,3 Zhibing Wu,3 Qin Xu,1,3 Jianping Song,1,3 Changsheng Deng1,3 1Artemisinin ...
Zheng S, Liang Y, Wang Z, Liu M, Chen Y, Ai Y, Guo W, Li G, Yuan Y, Xu Z, Wu W, Huang X, Wu Z, Xu Q, Song J, Deng C   +15 more
doaj  

SbWRKY62 Coordinates With SbERF096 to Activate Pterostilbene Biosynthesis and Targets a Xylanase Inhibitor Protein for Anthracnose Resistance in Sorghum

Plant, Cell &Environment, EarlyView.
ABSTRACT Sorghum anthracnose caused by Colletotrichum sublineola (C. sublineola) is a destructive disease leading to severe crop damages. Pterostilbene is a phytoalexin that contributes to defence responses in sorghum, but the transcriptional regulation of its biosynthesis remained poorly understood.
Yajing Li, Bofu Deng, Yiming Gan, Nan Lin, Dan Zhou, Clive Lo   +5 more
wiley   +1 more source

Artemisinin-Naphthoquine Combination (ARCO®): An Overview of the Progress

Pharmaceuticals, 2010
With the rapidly spreading resistance of Plasmodium falciparum to available non-artemisinin antimalarial drugs, new and novel pharmaceuticals are needed.
Qingyun Huang, Francis W. Hombhanje
doaj   +1 more source

Perspective: Artemisinin-Resistant Malaria and the Wolf [PDF]

The American Society of Tropical Medicine and Hygiene, 2012
The emergence of artemisinin-resistant malaria has been widely reported in scientific journals as well as the lay press. But how strong is the scientific evidence? It makes sense that artemisinin-resistant malaria would be emerging. Falciparum malaria has become resistant to every other drug.1 Why should artemisinin be different?
openaire   +2 more sources

N8‐Modified Quino[4,3,2‐Kl]acridines as Promising Antimalarial G‐Quadruplex Ligands

ChemBioChem, Volume 27, Issue 17, 14 September 2026.
A series of extended aromatic compounds with tunable substituents was synthesized using a multistep methodology which allows various substitutions of the 8H‐quino[4,3,2‐kl]acridine scaffold. This chemical series appeared as a promising way to new antimalarial drug candidates with high activity (IC50 < 100 nM), exhibiting a novel mechanism of action ...
Steve Saulnier, Marco Antônio G. B. Gomes, Mariam Salim, Maxime Guichonnet, Michel Nguyen, Laure Vendier, Flore Nardella, Jean‐Michel Augereau, Dennis Gomez, Anne Robert, Françoise Benoit‐Vical   +10 more
wiley   +1 more source

Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensity. [PDF]

, 2008
BACKGROUND: Artemisinin derivatives used in recently introduced combination therapies (ACTs) for Plasmodium falciparum malaria significantly lower patient infectiousness and have the potential to reduce population-level transmission of the parasite. With
Drakeley, Chris J, Bousema, Teun, Lucy C Okell, Bousema, T, Ghani, Azra C, Drakeley Chris J, Drakeley, CJ, Christopher J M Whitty, Okell Lucy C, Bousema Teun, Okell, Lucy C, Azra C Ghani, Ghani, AC, Whitty Christopher J. M, Ghani Azra C, Teun Bousema, Whitty, Christopher JM, Okell, LC, Whitty, CJ, Christopher J. M Whitty, Chris J Drakeley   +20 more
core   +1 more source

Genetic association between the Pfk13 gene mutation and artemisinin resistance phenotype in Plasmodium falciparum isolates from Yunnan Province, China

Malaria Journal, 2018
Background The problem of anti-malarial drug resistance is a long-term challenge faced by malaria control in Yunnan Province. Recently, the detection rates of chloroquine-resistant molecular markers (Plasmodium falciparum chloroquine resistant ...
Ying Dong, Jian Wang, Aiming Sun, Yan Deng, Mengni Chen, Yanchun Xu, Jingpo Xue   +6 more
doaj   +1 more source

Transcriptomic Analysis Reveals Core Genes and Mechanisms Linking Grilled Food Toxicants (4‐HNE, BaP, PhIP) to NASH‐HCC Progression

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
This study identifies a six‐gene signature (GSTA1, EPHX1, CYP2E1, GPX3, ALB, TF) that mediates how grilled food toxicants (4‐HNE, BaP, PhIP) synergistically drive NASH‐to‐HCC progression via oxidative stress, metabolic dysfunction, and immune microenvironment remodeling, providing a robust diagnostic nomogram for early risk stratification.
Bingbing Qin, Ye Zhang, Na Li, Jing Li, Yuehua Luo, Xi Tang, Ruisheng Zhou, Tianqi Cui, Ying Tang   +8 more
wiley   +1 more source