Results 151 to 160 of about 5,742,584 (242)

Substandard and Falsified Medicines, Regulatory Capacity and Public Health: A Narrative Review With a Focus on Africa

Public Health Challenges, Volume 5, Issue 3, September 2026.
Weak medicines regulation in Africa enables the circulation of substandard and falsified medicines, undermining treatment outcomes, accelerating antimicrobial resistance and eroding public trust. This narrative review synthesised 38 studies from 2000 to 2025, highlighting regulatory gaps, public health harms and regional disparities.
Ahmed Vandy, Nancy Oluwakemi Samai, Onome Thomas Abiri, Michael Lahai, Fawzi Thomas, Tamba Buffa, Sheku Mansaray, Alvin Turay, Augustus Osborne   +8 more
wiley   +1 more source

Artemisinin: A Panacea Eligible for Unrestrictive Use?

Frontiers in Pharmacology, 2017
Although artemisinin has been used as anti-malarial drug, accumulating evidence on the extended therapeutic potential of artemisinin emerges. Apart from anti-malaria and anti-tumor, artemisinin can also exert beneficial effects on some metabolic ...
Dong-Sheng Yuan, Yan-Ping Chen, Li-Li Tan, Shui-Qing Huang, Chang-Qing Li, Qi Wang, Qing-Ping Zeng   +6 more
doaj   +1 more source

The consequences of artemisinin resistance in falciparum malaria [PDF]

Malaria Journal, 2012
ظهرت مقاومة الأرتيميسينين في المتصورة المنجلية في جنوب شرق آسيا. تم توثيق أدلة على المقاومة في غرب كمبوديا منذ أكثر من ست سنوات، وفي العام الماضي تم الإبلاغ عن أدلة واضحة على المقاومة على الحدود بين تايلاند وميانمار. وبما أن مشتقات الأرتيميسينين هي حجر الزاوية في العلاج المضاد للملاريا سواء للملاريا غير المعقدة أو الشديدة، فإن فقدانها سيزيد من الاعتلال
openaire   +2 more sources

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, Volume 59, Issue 9, September 2026.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Acquired resistance of malarial parasites against artemisinin-based drugs: social and economic impacts

, 2010
Johanna M Porter-Kelley1, Joann Cofie2, Sophonie Jean2, Mark E Brooks1, Mia Lassiter1, DC Ghislaine Mayer21Life Sciences Department, ­Winston-Salem State University, Winston Salem, NC, USA; 2Department of Biology, Virginia Commonwealth University,
Sophonie Jean, et al, Johanna M Porter-Kelley, Joann Cofie   +3 more
core  

Age‐Related and Seasonal Variation in Malaria and Other Causes of Fever and Their Association With Clinical Outcomes in Southern Angola: A Hospital‐Based Study

Tropical Medicine &International Health, Volume 31, Issue 9, Page 1273-1283, September 2026.
ABSTRACT Background Acute febrile illnesses in sub‐Saharan Africa are often attributed to malaria, yet many patients test negative for malaria parasites. The aetiology of nonmalarial fevers remains understudied. Here, we examine likely causes of febrile illnesses and their association with poor clinical outcomes in Angola.
Helga E. M. Gonçalves, Maria Lina Antunes, Jorge Seixas, Marcelo U. Ferreira   +3 more
wiley   +1 more source

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

Routine delivery of artemisinin-based combination treatment at fixed health facilities reduces malaria prevalence in Tanzania: an observational study. [PDF]

, 2012
: BACKGROUND: Artemisinin-based combination therapy (ACT) has been promoted as a means to reduce malaria transmission due to their ability to kill both asexual blood stages of malaria parasites, which sustain infections over long periods and the immature
Mwita, A., Elling, B.F., Mwita, Alex, Mills, Anne, Tanner, M., Goodman, C. A., Roberts, J.M., Skarbinski, J., Elling, B. F., Elling, Berty F, Kahigwa, E., Roberts, J. M., Lyimo, T., Khatib, R.A., Njau, J. D., Somi, Masha F, Kahigwa, Elizeus, Njau, J.D., Macarthur, J. R., Somi, M.F., Kachur, S Patrick, Roberts, Jacquelin M, Skarbinski, Jacek, Goodman, Catherine A, Kabanywanyi, Abdunoor M, Smith, Ernest E, Goodman, C.A., Genton, B., Abdulla, S. M., Bloland, Peter B, Gutman, J. R., Kabanywanyi, A.M., Gutman, J.R., Lyimo, Thomas, Kachur, S.P., Bloland, P.B., Njau, Joseph D, Bloland, P. B., Mshinda, Hassan, Genton, Blaise, Tanner, Marcel, MacArthur, J.R., Somi, M. F., Abdulla, Salim M, Smith, E. E., Smith, E.E., Kachur, S. P., Kabanywanyi, A. M., Khatib, R. A., Mshinda, H., Gutman, Julie R, Abdulla, S.M., Mills, A., Khatib, Rashid A, Catherine A Goodman, Masha F Somi, Skarbinski, J, Njau Joseph D, Blaise Genton, Somi Masha F, Skarbinski Jacek, Kahigwa, E, Abdulla Salim M, Elizeus Kahigwa, Khatib, RA, Goodman, CA, Joseph D Njau, Lyimo Thomas, Kabanywanyi Abdunoor M, Njau, JD, Bloland Peter B, MacArthur John R, Jacquelin M Roberts, Elling Berty F, Roberts, JM, Marcel Tanner, Mshinda Hassan, Smith Ernest E, Genton Blaise, Gutman, JR, Rashid A Khatib, Kahigwa Elizeus, Alex Mwita, Julie R Gutman, Gutman Julie R, Kachur S, Abdunoor M Kabanywanyi, Ernest E Smith, Hassan Mshinda, Khatib Rashid A, Roberts Jacquelin M, Tanner Marcel, Mwita Alex, John R MacArthur, Peter B Bloland, MacArthur, JR, Macarthur, John R, Berty F Elling, Goodman Catherine A, Mills Anne, S Kachur, Thomas Lyimo, Jacek Skarbinski, Anne Mills, Elling, BF, Kabanywanyi, AM, Salim M Abdulla   +106 more
core   +1 more source

Development of artemisinin resistance in malaria therapy

Pharmacological Research, 2019
Malaria affects 200 million people worldwide. Today, the most successful treatments are artemisinin-based combination therapies (ACT). Resistance has already been described for the elder anti-malarials chloroquine, sulfadoxine-pyrimethamine and mefloquine.
Janine, Naß, Thomas, Efferth
openaire   +2 more sources

Rapid microarray-based method for monitoring of all currently known single-nucleotide polymorphisms associated with parasite resistance to antimalaria drugs. [PDF]

, 2007
Parasite drug resistance is partly conferred by single-nucleotide polymorphisms (SNPs), and monitoring them has been proposed as an alternative to monitoring drug resistance.
Regös, Attila, Beck, Hans-Peter, Puijalon, Odile, Huber, E., Crameri, A., Regos, A., Crameri, Andreas, Mugittu, K., Felger, Ingrid, Sismeiro, Odile, Laubscher, Daniel, Marfurt, J., Genton, B., Laubscher, D., Puijalon, O., Felger, I., Burki, Richard, Beck, H. P., Coppee, Jean Yves, Genton, Blaise, Maire, N., Coppee, J. Y., Marfurt, Jutta, Mugittu, Kefas, Maire, Nicolas, Burki, R., Huber, Eric, Sismeiro, O.   +27 more
core   +1 more source