Results 161 to 170 of about 5,742,584 (242)

K13-propeller gene polymorphisms in Plasmodium falciparum parasite population: a systematic review protocol of burden and associated factors

Systematic Reviews, 2018
Background Malaria control and prevention efforts continue to rely heavily on the use of medicines especially artemisinin agents. However, currently, the emergence of artemisinin resistance threatens this effort globally.
Moses Ocan, Dickens Akena, Sam Nsobya, Moses R. Kamya, Richard Senono, Alison Annet Kinengyere, Ekwaro Obuku   +6 more
doaj   +1 more source

Artemisinin Resistance and the Blame Game [PDF]

Clinical Infectious Diseases, 2016
Krishna, S, Staines, HM, Kremsner, PG
openaire   +2 more sources

Artemisinin resistance is a clear and present danger

Trends in Parasitology, 2013
Krishna and Kremsner suggest in their opinion piece on artemisinin resistance in falciparum malaria that the severe slowdown in parasite clearance after treatment with artemisinins, as observed in Southeast Asia, does not denote resistance and that the threat of the problem is being exaggerated by public health professionals who are ‘crying wolf’ [1 ...
Dondorp, A, Ringwald, P
openaire   +4 more sources

Chemical proteomics approach reveals the direct targets and the heme-dependent activation mechanism of artemisinin in Plasmodium falciparum using an activity-based artemisinin probe

, 2016
Artemisinin and its analogues are currently the most effective anti-malarial drugs. The activation of artemisinin requires the cleavage of the endoperoxide bridge in the presence of iron sources. Once activated, artemisinins attack macromolecules through
Qingsong Lin, Jigang Wang
core   +1 more source

Polymorphisms in Pfkelch13 domains before and after the introduction of artemisinin-based combination therapy in Southwest Nigeria.

PLoS ONE
Emergence of artemisinin resistance in East Africa has greatly necessitated surveillance of artemisinin resistance in other African countries with great malaria burden.
Abiodun Amusan, Olugbenga Akinola, Kazeem Akano, María Hernández-Castañeda, Jenna K Dick, Akintunde Sowunmi, Geoffrey Hart, Grace Gbotosho   +7 more
doaj   +1 more source

Photoaffinity probe‐based antimalarial target identification of artemisinin in the intraerythrocytic developmental cycle of Plasmodium falciparum

iMeta
Malaria continues to pose a serious global health threat, and artemisinin remains the core drug for global malaria control. However, the situation of malaria resistance has become increasingly severe due to the emergence and spread of artemisinin ...
Peng Gao, Jianyou Wang, Chong Qiu, Huimin Zhang, Chen Wang, Ying Zhang, Peng Sun, Honglin Chen, Yin Kwan Wong, Jiayun Chen, Junzhe Zhang, Huan Tang, Qiaoli Shi, Yongping Zhu, Shengnan Shen, Guang Han, Chengchao Xu, Lingyun Dai, Jigang Wang   +18 more
doaj   +1 more source

Characterization of artemisinin resistance in plasmodium falciparum

, 2017
Artemisinins are an important class of antimalarials because of their remarkable antimalarial activity and exceptional safety profile. However, the decline in efficacy of artemisinin-based drugs jeopardizes global efforts that aim to control and ...
Rocamora, Frances Maureen C.
core   +1 more source

The Effects of Pharmacogenetics on Pharmacokinetics\ud of Artemisinin-Based Combinations in Malaria Patients [PDF]

, 2009
Malaria is a vector-borne infectious disease caused by protozoan parasites of the genus Plasmodium. If not treated appropriately, human P. falciparum malaria can quickly become life-threatening, leading to an estimated 900’000 annual deaths globally. Key
Hodel, Eva Maria
core  

Evaluating the cost-effectiveness of artemisinin-based combination antimalarial drugs and malaria rapid diagnostic tests within the context of effective vector control : case study of Southern Africa [PDF]

, 2006
Includes bibliographical references (p. 253-265)This study seeks to use the techniques of cost-effectiveness analysis to evaluate, within the context of effective vector control, the change to artemisinin-based combination therapies (ACTs) as first ...
Zikusooka, Charlotte Muheki
core  

Artemisinin Resistance in Southeast Asia [PDF]

Clinical Infectious Diseases, 2016
openaire   +2 more sources