Results 211 to 220 of about 97,443 (299)

Synergistic effects of core-shell structured piperazine pyrophosphate microcapsules on fire safety and mechanical property in styrenic thermoplastic elastomer.

Journal of Colloid and Interface Science, 2023
In this study, core-shell structured piperazine pyrophosphate (PAPP) is designed to enhance the fire safety and mechanical property of styrenic thermoplastic elastomer (TPE) composites. The PAPP is microencapsulated with carbon nanotube modified melamine-
Min Zhu, P. Jia, Guisheng Yang, Lei Song, Yuan Hu, Bibo Wang   +5 more
semanticscholar   +1 more source

Design, Synthesis, and Antifungal Activity of Novel Chalcone Derivatives Containing a Piperazine Fragment.

Journal of Agricultural and Food Chemistry, 2022
In an attempt to find the biorational pesticides, 20 novel chalcone derivatives containing a piperazine fragment were designed and synthesized. Their fungicidal activities and preliminarily action mechanism against Rhizoctonia solani were evaluated ...
Qing Zhou, Xu Tang, Shuai Chen, W. Zhan, Die Hu, Ran Zhou, Nan Sun, Yongjun Wu, Wei Xue   +8 more
semanticscholar   +1 more source

Novel piperazine-containing oligomer as flame retardant and crystallization induction additive for thermoplastics polyurethane

Chemical Engineering Journal, 2020
In flame-retarding polymer field, it is very difficult to achieve simultaneous outstanding flame retardancy and excellent mechanical properties, thus causing the serious lack of high-performance flame-retarded polymers.
Cong Deng, Yu-Zhong Wang
exaly   +2 more sources

The piperazine scaffold for novel drug discovery efforts: the evidence to date

Expert Opinion on Drug Discovery, 2022
Introduction Piperazine is a structural element present in drugs belonging to various chemical classes and used for numerous different therapeutic applications; it has been considered a privileged scaffold for drug design.
M. Romanelli, D. Manetti, Laura Braconi, S. Dei, Alessio Gabellini, E. Teodori   +5 more
semanticscholar   +1 more source

Flame retardancy of biodegradable polylactic acid with piperazine pyrophosphate and melamine cyanurate as flame retardant

Journal of fire sciences, 2022
A flame-retardant polylactic acid composite added with piperazine pyrophosphate and melamine cyanurate was developed. Piperazine pyrophosphate and melamine cyanurate showed synergistic effect in the polylactic acid composites.
Hongxu Chen, Wei Xia, Nan Wang, Yang Liu, Penghui Fan, Song Wang, Sanxi Li, Jie Liu, Tao Tang, Ailing Zhang, Zhan Ding, Wei Wu, Qi Chen   +12 more
semanticscholar   +1 more source

Piperazine-Based Mitochondria-Immobilized pH Fluorescent Probe for Imaging Endogenous ONOO- and Real-Time Tracking of Mitophagy.

ACS Applied Bio Materials, 2022
ONOO- is mainly produced in mitochondria, and dysfunctional and damaged mitochondria are degraded in lysosomes through autophagy, so it is important to synthesize a single probe for dual detection of ONOO- and mitophagy.
Minglu Li, Yue Huang, Shengmei Song, S. Shuang, C. Dong   +4 more
semanticscholar   +1 more source

Piperazine derivatives with potent drug moiety as efficient acetylcholinesterase, butyrylcholinesterase, and glutathione S‐transferase inhibitors

Journal of biochemical and molecular toxicology, 2022
Cholinesterases catalyze the breakdown of the neurotransmitter acetylcholine (ACh), a naturally occurring neurotransmitter, into choline and acetic acid, allowing the nervous system to function properly.
M. Karaytuğ, Neslihan Balcı, F. Türkan, Mahmut Gurbuz, M. Demirkol, Z. Namlı, L. Tamam, I. Gulcin   +7 more
semanticscholar   +1 more source

Piperazine, a Key Substructure for Antidepressants: Its Role in Developments and Structure‐Activity Relationships

ChemMedChem, 2021
Depression is the single largest contributor to global disability with a huge economic and social burden on the world. There are a number of antidepressant drugs on the market, but treatment‐resistant depression and relapse of depression in a large ...
R. Kumar, Bhaskar Sahu, S. Pathania, P. Singh, M. Akhtar, B. Kumar   +5 more
semanticscholar   +1 more source

Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment.

Bioorganic chemistry (Print), 2021
We synthesized eleven new amiridine-piperazine hybrids 5a-j and 7 as potential multifunctional agents for Alzheimer's disease (AD) treatment by reacting N-chloroacetylamiridine with piperazines. The compounds displayed mixed-type reversible inhibition of
G. Makhaeva, S. Lushchekina, N. Kovaleva, Tatiana Yu Astakhova, N. Boltneva, E. Rudakova, O. Serebryakova, A. Proshin, I. Serkov, T. P. Trofimova, V. Tafeenko, E. Radchenko, V. Palyulin, V. Fisenko, J. Korábečný, O. Soukup, R. Richardson   +16 more
semanticscholar   +1 more source

Biphenyl-3-oxo-1,2,4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory.

Bioorganic chemistry (Print), 2019
A series of novel piperazine tethered biphenyl-3-oxo-1,2,4-triazine derivatives were designed, and synthesized. Amongst the synthesized analogs, compound 6g showed significant non-competitive inhibitory potential against acetylcholinesterase (AChE, IC50;
P. N. Tripathi, Pavan Srivastava, Piyoosh Sharma, M. Tripathi, Ankit Seth, Avanish Tripathi, S. Rai, S. P. Singh, S. Shrivastava   +8 more
semanticscholar   +1 more source