Results 241 to 250 of about 25,392 (338)

Snake Venom Protease Detection and Inhibition in Serum

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A fluorescence assay enables sensitive detection of the activities of snake venom metalloproteases (SVMP) and serine proteases (SVSP) from viper venoms in buffer and serum. In combination with effective low‐molecular‐weight inhibitors such as ilomastat and nafamostat, this approach offers new prospects for the rapid diagnosis and adjunctive therapy of ...
Mareike Riedel, Christian Kersten
wiley   +1 more source

Dearomative spirocyclization of ynamides. [PDF]

Chem Sci
Agbaria M, Egbaria N, Nairoukh Z.
europepmc   +1 more source

Identification of 1-{2-[4-chloro-1′-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4′-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y1 antagonist as an antiplatelet agent

, 2014
Yoon Jeon, Wu Yang, Jennifer X. Qiao, Ling Li, Réjean Ruel, Carl Thibeault, Sheldon Hiebert, Tammy C. Wang, Yufeng Wang, Yajun Liu, Charles G. Clark, Henry S. Wong, Juliang Zhu, Dauh‐Rurng Wu, Dawn Sun, Bang‐Chi Chen, Arvind Mathur, Silvi A. Chacko, Mary F. Malley, Xueqing Chen, Hong Shen, Christine Huang, William A. Schumacher, Jeffrey S. Bostwick, Anne B. Stewart, Laura A. Price, Ji Hua, Danshi Li, Paul Lévesque, Dietmar Seiffert, Robert Rehfuss, Ruth R. Wexler, Patrick Y. S. Lam   +32 more
openalex   +1 more source

The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Thalidomide serves as a molecular nexus linking chemistry and biology: advances in synthesis and structural understanding enable protein degradation technologies, while its immunomodulatory activity underpins anti‐inflammatory and anticancer therapies.
Konstantina Nikovia, Michael Kapsalis, Michael Georgoulakis, Athanasios Panousis, Constantinos G. Neochoritis   +4 more
wiley   +1 more source

A new chiral heterocyclic 1,1-enediamine as a precursor to piperidines

ARKIVOC, 2003
Raymond C. F. Jones, Simon C. Hirst
doaj   +1 more source

A Brønsted acid-base approach for the net monoselective C-F substitution of (trifluoromethyl)alkanes. [PDF]

Chem Sci
Coradi NJ, Bandar JS.
europepmc   +1 more source

Piperidine derivatives as nonprostanoid IP receptor agonists 2

, 2016
Ryoji Hayashi, Hiroaki Ito, Takeshi Ishigaki, Yasuhiro Morita, Mitsuko Miyamoto, Masafumi Isogaya   +5 more
openalex   +1 more source

Multifactorial Perspective for Greening Solid‐Phase Peptide Synthesis: Rigid Polyacrylate Macroporous Resin in Combination with Green Solvents

ChemSusChem, Volume 19, Issue 7, 14 April 2026.
A rigid, non‐swelling polyacrylate resin enables greener solid‐phase peptide synthesis by allowing various green solvents during the peptide synthesis and significantly reduced process mass intensity without compromising peptide synthesis efficiency/purity.
Sikabwe Noki, Ashish Kumar, Cheng Zhang, Alesandra Basso, Simona Serban, Xiaokang Kou, Yanjun Li, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio   +9 more
wiley   +1 more source

Synthesis of Chiral Saturated Heterocycles Bearing Quaternary Centers via Enantioselective β-C(sp³)-H Activation of Lactams. [PDF]

J Am Chem Soc
Lu P, Burgenson WR, Simmons BJ, Liu S, Yeung KS, Qiao JX, Yu JQ.   +6 more
europepmc   +1 more source

Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: Development of a [3.3.0]-based series and other piperidine bioisosteres

, 2014
Douglas J. Sheffler, Michael T. Nedelcovych, Richard D. Williams, Stephen C. Turner, Brittany B. Duerk, Megan R. Robbins, Sataya B. Jadhav, Colleen M. Niswender, Carrie K. Jones, P. Jeffrey Conn, R. Nathan Daniels, Craig W. Lindsley   +11 more
openalex   +1 more source