Results 231 to 240 of about 25,392 (338)

Peptide Angio‐3 Attenuates Pulmonary Fibrosis Via Modulation of the Coagulation Factor Xa—Protease‐Activated Receptor‐1 Signaling Axis

open access: yesThe FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Schematic illustrating the mechanism by which the peptide Angio‐3 attenuates pulmonary fibrosis. Following lung injury, activation of the coagulation cascade via Factor Xa (FXa) signals through protease‐activated receptor‐1 (PAR‐1) to activate fibroblasts and promote fibrosis.
Dan Wang   +9 more
wiley   +1 more source

REILLY PIPERIDINES [PDF]

open access: yesChemical & Engineering News Archive, 1963
openaire   +1 more source

Probing the Cancer Mutational Landscape of KMT2 Regulatory Subunits

open access: yesThe FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Pipeline to characterize the KMT2 cancer mutational landscape starts with querying genomic databases (top left) for mutations mapping to ASH2L, RbBP5, WDR5, and DPY‐30. Subsequent steps include the expression of these mutants in cell (bottom left), their systemic purification and biochemical characterization using isothermal titration calorimetry ...
Sabrina Grégoire   +9 more
wiley   +1 more source

Synthesis of Polyhydroxylated Pyrrolidinyl Analogs of Sugar Nucleotides. Experimental and Computational Studies on Their Interactions With GalNAC‐T's

open access: yesChemBioChem, Volume 27, Issue 7, 14 April 2026.
A multidisciplinary approach based on organic synthesis supported by quantum mechanical calculations, efficient phosphorylation methods, affinity studies using conventional techniques and saturation transfer difference nuclear magnetic resonance, together with molecular dynamics simulations, has enabled the preparation of nucleotide analogs with ...
Pedro Merino   +10 more
wiley   +1 more source

Regiodivergent C3 and C4 Amination of Quinolines via Radical and Ionic Pathways

open access: yesAngewandte Chemie, Volume 138, Issue 16, 13 April 2026.
A regiodivergent strategy converts a single N‐aminoquinolinium precursor into either C3‐ or C4‐aminated quinolines. Nucleophile‐induced dearomatization diverges into light‐driven N‐centered radical capture (C3) or base‐promoted SNAr (C4), enabling rapid assembly of aminoquinoline libraries and late‐stage diversification.
Ye‐Eun Kim   +3 more
wiley   +2 more sources

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