Results 211 to 220 of about 25,392 (338)

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 10, Page 2307-2323, May 2026.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert   +13 more
wiley   +1 more source

Trithiazacrown Ethers Containing Piperidine Heterocycle: Synthesis, Structural Characterization and Evaluation Of α‐Glucosidase Inhibitory Activity [PDF]

open access: bronze
Nguyen Tien Dat   +7 more
openalex   +1 more source

AlkaPlorer: A database‐driven explorer for natural alkaloids and derivatives

open access: yesJournal of Integrative Plant Biology, Volume 68, Issue 5, Page 1384-1398, May 2026.
The alkaloid database AlkaPlorer integrates over 130,000 compounds across 12,250 species. By linking chemical structures with biological and evolutionary data, it reveals how these molecules evolve and function. This platform serves as a vital resource for AI‐driven discovery in plant metabolism and modern drug development. ABSTRACT Alkaloids, renowned
Jiahao Li   +5 more
wiley   +1 more source

Crystal structure of a new mixed-metal coordination polymer consisting of NiII piperidine-dithiocarbamate and pentanuclear CuI—I cluster units [PDF]

open access: gold, 2018
Kento Himoto   +7 more
openalex   +1 more source

Fair and Square: Design, Synthesis and Biological Evaluations of Squaric Acid Derivatives as Novel HDAC8 Inhibitors

open access: yesChemMedChem, Volume 21, Issue 8, 28 April 2026.
Histone deacetylase 8 (HDAC8) is a clinically validated target in neuroblastoma, where isoform selective inhibition offers a strategy to suppress tumour growth while limiting off‐target toxicity. Hydroxamic acids remain the dominant zinc‐binding group (ZBG) in HDAC inhibitors but are also associated with metabolic instability, suboptimal ...
Nathan Long   +3 more
wiley   +1 more source

Chronic Ataxic Neuropathy With Disialosyl Antibodies Responsive to Zanubrutinib. [PDF]

open access: yesEur J Neurol
Tierro B   +7 more
europepmc   +1 more source

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