Results 211 to 220 of about 25,392 (338)
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert +13 more
wiley +1 more source
Nickel-Catalyzed Enantioselective Diboration of 1,2-Dihydropyridines: Application and Insight into the Selectivity and Mechanism. [PDF]
Berwanger MR +3 more
europepmc +1 more source
Trithiazacrown Ethers Containing Piperidine Heterocycle: Synthesis, Structural Characterization and Evaluation Of α‐Glucosidase Inhibitory Activity [PDF]
Nguyen Tien Dat +7 more
openalex +1 more source
AlkaPlorer: A database‐driven explorer for natural alkaloids and derivatives
The alkaloid database AlkaPlorer integrates over 130,000 compounds across 12,250 species. By linking chemical structures with biological and evolutionary data, it reveals how these molecules evolve and function. This platform serves as a vital resource for AI‐driven discovery in plant metabolism and modern drug development. ABSTRACT Alkaloids, renowned
Jiahao Li +5 more
wiley +1 more source
Biocatalytic C-H oxidation meets radical cross-coupling: Simplifying complex piperidine synthesis. [PDF]
He J +6 more
europepmc +1 more source
Crystal structure of a new mixed-metal coordination polymer consisting of NiII piperidine-dithiocarbamate and pentanuclear CuI—I cluster units [PDF]
Kento Himoto +7 more
openalex +1 more source
Histone deacetylase 8 (HDAC8) is a clinically validated target in neuroblastoma, where isoform selective inhibition offers a strategy to suppress tumour growth while limiting off‐target toxicity. Hydroxamic acids remain the dominant zinc‐binding group (ZBG) in HDAC inhibitors but are also associated with metabolic instability, suboptimal ...
Nathan Long +3 more
wiley +1 more source
Chronic Ataxic Neuropathy With Disialosyl Antibodies Responsive to Zanubrutinib. [PDF]
Tierro B +7 more
europepmc +1 more source

