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A robust continuous flow chemoenzymatic process was developed for the stereoselective synthesis of cis‐(2R,6R)‐2,6‐disubstituted piperidines, including the natural alkaloid (–)‐pinidinone. The asymmetric transamination of α,β‐unsaturated ketones was catalyzed by immobilized ATA‐117, followed by spontaneous aza‐Michael cyclization, providing the desired
Sara Vicinanza +11 more
wiley +1 more source
Ring Expansions of 1,2-Amino Alcohols to Amine Heterocycles Enabled by Proton-Coupled Electron Transfer. [PDF]
Thach DQ, Knowles RR.
europepmc +1 more source
Reductive Transamination of Pyridinium Salts to N-Aryl Piperidines. [PDF]
Chen Z +8 more
europepmc +1 more source
Diastereoselective Cyclopropanation with Secondary Diazoacetamides to Access <i>endo</i>-Azabicyclo[3.1.0]hexane-6-carboxamides. [PDF]
Nguyen TH +4 more
europepmc +1 more source
Pancreatic ductal adenocarcinoma with ITSN1-ALK fusion: sustained response to alectinib with 19-month progression-free survival. [PDF]
Liu C, Wang X, Chen L.
europepmc +1 more source
Significant improvement with ivarmacitinib after suboptimal response to tofacitinib in severe alopecia areata: a case report and literature review. [PDF]
Wan Z, Wang Y, Yang D.
europepmc +1 more source
The Use of Piperidinium Surfactants in Nematicide Formulations. [PDF]
Kushnazarova R +6 more
europepmc +1 more source
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