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Anticonvulsant Activity and Neurotoxicity of Piperonyl Butoxide in Mice
Epilepsia, 1984Summary: Piperonyl butoxide, a microsomal monooxygenase inhibitor, administered intraperitoneally to mice exerts peak anti‐maximal electroshock activity and peak neurotoxicity at 5 and 7 h, respectively. The median neurotoxic dose is 1,690 mg/kg. In the maximal electroshock seizure test, the median effective dose (ED50) is 457 mg/kg and the protective
S B, Ater +3 more
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Piperonyl butoxide mutagenicity in human RSa cells
Mutation Research/Genetic Toxicology, 1995Piperonyl butoxide (PB) is used as a pesticide synergist and food additive. Its chemically induced mutagenicity was found in cultured human RSa cells by determination of ouabain-resistant (Ouar) phenotypic mutation, with the highest frequency at the concentration of 0.2 microgram/ml.
H, Suzuki, N, Suzuki
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Hepatotoxicity of piperonyl butoxide in male F344 rats
Toxicology, 1993Male F344 rats were given 0, 0.6, 1.2 or 2.4% of piperonyl butoxide in the diet. At 1, 2, 4 or 12 weeks after the beginning of the experiment, liver and kidney weight and serum clinical parameters were determined and livers and kidneys were examined with light microscopy.
T, Fujitani, Y, Tada, M, Yoneyama
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Effects of piperonyl butoxide on F1 generation mice
Toxicology Letters, 1992Piperonyl butoxide (PB), used in Japan as a pesticide synergist and food additive, was administered to mice from 5 weeks of age in the F0 generation to 9 weeks of age in the F1 generation, in the diet at levels of 0 (control), 0.15, 0.30 and 0.60%, and some reproductive, developmental and behavioral parameters were measured.
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Piperonyl butoxide, a synergist of pesticides can elicit male-mediated reproductive toxicity
Reproductive Toxicology, 2021Woo-Sung Kwon, Jeong-Won Bae
exaly
Piperonyl butoxide induces hepatocellular carcinoma in male CD-1 mice
Archives of Toxicology, 1994S Oishi, T Fujitani
exaly

