Results 41 to 50 of about 182,979 (366)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Characteristics of the micropseudokarst landforms in Pâclele Mari mud volcanic area (Romania)

Acta Carsologica
In this paper, we present the results of the geomorphological study of the micro pseudokarst landfoms developed on Pâclele Mari mud volcanic site that belongs to the famous mud volcanic area Berca-Arbănași, Buzău Subcarpathians, Romania.
Janos Moga, Katalin Fehér, Daniela Strat   +2 more
doaj   +1 more source

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source

Validation of the Pediatric Arthritis Ultrasound Scoring System for the Elbow, Wrist, and Finger Joints in Children With Juvenile Idiopathic Arthritis

Arthritis Care &Research, EarlyView.
Objective We aimed to validate the Pediatric Arthritis Ultrasound Scoring System (PAUSS) for upper extremity joints in children with juvenile idiopathic arthritis (JIA). Methods Children with JIA were evaluated for elbow, wrist, or finger arthritis by clinical examination (CE) and musculoskeletal ultrasound (MSUS) with images scored according to the ...
Patricia Vega‐Fernandez, Pinar Ozge Avar‐Aydin, Kelly Rogers, Daniel J. Lovell, Jennifer Huggins, Alexei Grom, Hermine I. Brunner, Grant S. Schulert, Sheila T. Angeles‐Han, Mekibib Altaye, Amy Cassedy, Arthur B. Meyers, Tracy V. Ting   +12 more
wiley   +1 more source

Investigation on ultimate strength of thin wall tee pipe for sodium cooled fast reactor under seismic loading

Mechanical Engineering Journal, 2016
It is important to investigate the failure mode and ultimate strength of piping components in order to evaluate the seismic integrity of piping. Many failure tests of thick wall and high pressure piping for Light Water Reactors (LWRs) have been ...
Tomoyoshi WATAKABE, Kazuyuki TSUKIMORI, Akihito OTANI, Makoto MORIIZUMI, Naoaki KANEKO   +4 more
doaj   +1 more source

Leakage of gasoil from side cut piping in crude distillation unit of a petroleum refinery

Journal of Pipeline Science and Engineering, 2022
This paper reports failure of elbow from side cut piping after three years of refinery gasoil service and piping metallurgy was SS316L austenitic stainless steel.
Chidambaram Subramanian
doaj   +1 more source

Piping in newsprint rolls [PDF]

, 1988
The problem is concerned with the formation of 'piping' or 'moisture welts' on rolls of newsprint; The goal was to develop a mathematical model which would explain why and how these defects occurred, and what might be done to alleviate ...
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Integrating Patient‐Reported Quality Measures in SLE: Development of the American College of Rheumatology Implementation Guide

Arthritis Care &Research, Accepted Article.
Objective To support high‐quality, patient‐centered care for systemic lupus erythematosus (SLE), the American College of Rheumatology (ACR) developed evidence‐based measures incorporating clinical and patient‐reported outcomes measures (PROMs). Using the Consolidated Framework for Implementation Research (CFIR), we conducted semi‐structured interviews ...
Catherine Nasrallah, Cherish Wilson, Christine Hariz, Christie M Bartels, Shanthini Kasturi, Wambui Machua, Amy Bennett, Kate Chiseri, Allison Plitman, Starla Hairston Blanks, April Jorge, Patti Katz, Jinoos Yazdany, Shivani Garg   +13 more
wiley   +1 more source

Experimental approach for understanding the dynamic behaviors of bentonite buffer piping erosion

Mechanical Engineering Journal, 2020
In Japan, as in other countries, bentonite-based buffer materials are expected to play roles in reducing stress from rock masses and mitigating nuclide migration in the geological disposal of high-level radioactive waste.
Tomoko ISHII, Masahiro KAWAKUBO, Ichizo KOBAYASHI, Yuichi NIIBORI   +3 more
doaj   +1 more source