Results 1 to 10 of about 9,855 (261)

Elucidating the Three‐Dimensional Structure of Piracetam through Rotational Spectroscopy [PDF]

ChemistryOpen
Herein we report on the most stable structures adopted by piracetam, a nootropic drug, in isolated conditions. A chirped pulse Fourier transform microwave spectrometer (CP‐FTMW) coupled with a laser ablation source has been employed to explore the ...
S. Mato, S. Municio, Prof. J. L. Alonso, Dr. E. R. Alonso, Dr. I. León   +4 more
doaj   +3 more sources

Protective effect of co-administration of caffeine and piracetam on scopolamine-induced amnesia in Wistar rats

Current Research in Pharmacology and Drug Discovery, 2021
Alzheimer's disease is a cerebrovascular disorder characterized by progressive loss of the mental capabilities. The novel therapeutic agent piracetam is a cyclic derivative of γ-aminobutyric acid and one of the oldest recognized synthetic nootropics ...
Subhash Chaturvedi, Aditya Ganeshpurkar, Abhishek Shrivastava, Nazneen Dubey   +3 more
doaj   +2 more sources

The comparison of levetiracetam and piracetam effectiveness on breath-holding spells in children: A randomized controlled clinical trial

Advanced Biomedical Research, 2021
Background: We aimed to compare the effectiveness of Levetiracetam and Piracetam on the severity and frequency of spells in children with severe breath-holding spells (BHS), i.e.
Mohammad Reza Ghazavi, Mohammad Mehdi Salehi, Jafar Nasiri, Omid Yaghini, Vahid Mansouri, Neda Hoseini   +5 more
doaj   +2 more sources

Hepatic encephalopathy complications are diminished by piracetam via the interaction between mitochondrial function, oxidative stress, inflammatory response, and locomotor activity

Heliyon, 2023
Background: of the study: Hepatic encephalopathy (HE) is a complication in which brain ammonia (NH4+) levels reach critically high concentrations because of liver failure.
Hossein Niknahad, Ali Mobasheri, Abdollah Arjmand, Elahe Rafiei, Sepideh Alidaee, Hadi Razavi, Sara Bagheri, Heresh Rezaei, Samira Sabouri, Asma Najibi, Forouzan Khodaei, Seyyed Mohammad Amin Kashani, Mohammad Mehdi Ommati, Reza Heidari   +13 more
doaj   +2 more sources

Development and Optimization of Piracetam and Shatavarin IV-Loaded Nanoemulsion for Alzheimer's Disease Therapy: In Silico and Experimental Analysis. [PDF]

ACS Omega
Alzheimer’s disease (AD) presents a significant challenge due to cognitive decline resulting from nerve cell degeneration. Shatavarin IV, a prominent bioactive compound fromAsparagus racemosus and Piracetam, has been investigated for its neuroprotective ...
Nadeem M, Majid H, Ansari MD, Ahmad FJ, Parvez S, Akhtar M, Ahmad S, Najmi AK.   +7 more
europepmc   +2 more sources

Solid lipid nanoparticles enhance piracetam’s neuroprotective action in streptozotocin-induced cognitive dysfunction [PDF]

Discover Nano
Diabetes-induced cognitive dysfunction remains an unaddressed medical concern across the globe with limited options left with conventional drug therapy.
Abhishek Mishra, Bhabani Sankar Satapathy, Pratap Kumar Sahu   +2 more
doaj   +2 more sources

Piracetam as a Therapeutic Agent for Doxorubicin-Induced Cognitive Deficits by Enhancing Cholinergic Functions and Reducing Neuronal Inflammation, Apoptosis, and Oxidative Stress in Rats

Pharmaceuticals, 2022
Cancer chemotherapy is known to cause cognitive defects in patients. Our study investigated the effect of piracetam (PIRA; 200 or 400 mg/kg) against doxorubicin (DOX)-induced cognitive deficits in a rat model. The cognitive parameters were analyzed using
Vasudevan Mani, Syed Imam Rabbani, Ali Shariq, Palanisamy Amirthalingam, Minhajul Arfeen   +4 more
doaj   +2 more sources

Pharmacokinetics and Bioequivalence Evaluation of Piracetam Tablet: A Randomized, Single-Dose, Two-Period, Crossover Study in Healthy Chinese Participants Under Fasting and Fed Conditions [PDF]

Drugs in R&D
Background Piracetam, a nootropic drug, is widely used for treating cognitive impairments. However, pharmacokinetic and bioequivalence data for piracetam formulations in the Chinese population are limited.
Hegui Yan, Ming Zhou, Zhixiang Pan, Yu Peng, Jie Wang, Xiuwen Li, Yafang Xie, Qianying Liu, Cuiping Huang, Qiuhong Wang, Guan Liu   +10 more
doaj   +2 more sources

Investigation of the Formation Process of Two Piracetam Cocrystals during Grinding

Pharmaceutics, 2011
Cocrystal formation rates during dry grinding and liquid-assisted grinding were investigated by X-ray powder diffractometry and Raman spectroscopy. Two polymorphic forms of piracetam were used to prepare known piracetam cocrystals as model substances, i ...
Keith Gordon, Thomas Rades, Claudia S. Leopold, Clare J. Strachan, Marten Klukkert, Albrecht Sakmann, Korbinian A. M. Löbmann, Sönke Rehder   +7 more
doaj   +3 more sources

Influence of Piracetam on Gliclazide—Glycated Human Serum Albumin Interaction. A Spectrofluorometric Study

Molecules, 2018
Advanced Glycation End-Products (AGEs) are created in the last step of protein glycation and can be a factor in aging and in the development or worsening of many degenerative diseases (diabetes, chronic kidney disease, atherosclerosis, Alzheimer’s ...
Agnieszka Szkudlarek, Jadwiga Pożycka, Małgorzata Maciążek-Jurczyk   +2 more
doaj   +2 more sources