Results 61 to 70 of about 1,456 (263)
Advanced Science, EarlyView.RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu +13 more
wiley +1 more source
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Journal of World-Systems Research, 2016 This article uses world-systems analysis to examine the role that pirates and privateers played in the competition between European core states in the Atlantic and Caribbean frontier during the seventeenth and eighteenth centuries. Piracy was an integral
P. Nick Kardulias, Emily Butcher
doaj +1 more source
Advanced Science, EarlyView.A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang +9 more
wiley +1 more source
Advanced Science, EarlyView.A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo +13 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Viruses often hijack host developmental programs to promote infection, but the mechanistic links between reproductive regulation and antiviral immunity remain incompletely understood. Here, we identify a virus‐triggered hierarchical degradation cascade that links antiviral immunity and fertility regulation in rice. We show that the rice grassy
Yuansheng Wu +13 more
wiley +1 more source
Punishing the sea wolf: corsairs and cannibals in the early modern Caribbean
NWIG, 2003 Looks at how Western law was interpreted and applied to perceived cannibals and corsairs in the Spanish Caribbean in the 16th and 17th c., by Spanish jurists in the period, and at the development of the cannibal and corsair image in Spanish culture ...
Kris Lane
doaj
Anna Tarwacka, Romans and Pirats. Legal Perspective, 2009
Czasopismo Prawno-Historyczne, 2011 Recenzja: Anna Tarwacka, Romans and Pirates. Legal Perspective, Wydawnictwo Uniwersytetu Kardynała Stefana Wyszyńskiego, Warszawa 2009, ss. 199.
Piotr Κołodko
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A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates
Advanced Science, EarlyView.Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao +7 more
wiley +1 more source
Assessment of global shipping risk caused by maritime piracy. [PDF]
Heliyon, 2023 He Z, Wang C, Gao J, Xie Y.
europepmc +1 more source