Results 71 to 80 of about 1,456 (263)
Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication
Advanced Science, EarlyView.NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan +7 more
wiley +1 more source
A Contemporary Approach to the Oldest International Crime
Utrecht Journal of International and European Law, 2017 Maritime piracy began to re-emerge a decade ago, mostly off the coast of Somalia, thereby presenting major economic, security and humanitarian concerns. Prosecuting piracy raises many issues, not in the least because traditional maritime piracy from 200 ...
Michael Scharf, Mistale Taylor
doaj +1 more source
Advanced Science, EarlyView.A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li +5 more
wiley +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
, 2011 I watch pirate television. Will you forgive me some narcissography in this first blog, given that enticing new status? I live in Mexico City, the biggest in the world. It also lays claim to more political demonstrations than anywhere else, more film clubs than Paris, more abortions than London, and the region's most corrupt police force.
openaire +2 more sources
Advanced Science, EarlyView.This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan +6 more
wiley +1 more source
TERMIN „PIRAT” W PISMACH CYCERONA – INWEKTYWA CZY COŚ WIĘCEJ?
Zeszyty Prawnicze, 2016 The Term ‘Pirate’ in Cicero’s Works – Invective or More? Summary Being a remarkably acute politician, Cicero was aware of the fact that in order to discredit his opponents he had to appeal to his audience’s deepest fears.
Anna Tarwacka
doaj +1 more source
Advanced Science, EarlyView.This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai +12 more
wiley +1 more source
NWIG, 2000 [First paragraph] Women Pirates and the Politics of the Jolly Roger. ULRIKE KLAUSMANN, MARION MEINZERIN & GABRIEL KUHN. New York: Black Rose Books, 1997. x + 280 pp. (Paper US$ 23.99) Pirates!
Kris Lane
doaj
Marcus Rediker, Outlaws of the Atlantic. Sailor, Pirates, and Motley Crews in the Age of Sail (2014)
Archivos de Historia del Movimiento Obrero y la Izquierda, 2016 Reseña de Marcus Rediker, Outlaws of the Atlantic. Sailor, Pirates, and Motley Crews in the Age of Sail, Londres: Verso, 2014, 241 pgs.
Lucas Poy
doaj +1 more source