Results 61 to 70 of about 86,601 (265)

Delimitation of the final pit of open-pit mines using the maximum flow Pseudoflow method [PDF]

open access: yesInternational Journal of Mining and Geo-Engineering
The primary aim of this study was to define the final pit boundaries utilizing the maximum flow Pseudoflow method in an open-pit mining context. Our methodology encompassed exploratory data analysis (EDA), establishing geomechanical and economic factors,
Jairo Marquina Araujo   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Controlled mining technology of multi-weak bedding down-dipping soft rock slope

open access: yesMeikuang Anquan
Aiming at the problem of coal at the lower part of multi-weak bedding down-dipping soft rock slope, from the perspective of controllable slope deformation risk and the maximization of resource recovery, based on the analysis of geological data and weak ...
Jiao WANG   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Noclegi pracowników delegowanych finansowane przez pracodawcę a przychód ze stosunku pracy. Glosa aprobująca do wyroku NSA z 1 sierpnia 2023 r., II FSK 270/21, LEX nr 3612004

open access: yesKrytyka Prawa
Wide definition of “employment income” set out in Polish Personal Income Act of 26 July 1991 makes it challenging for the tax authorities and administrative courts to qualify remuneration items as taxable income.
Robert Zieliński, Mateusz Zawadka
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

The recovery of mitotic disturbances in the root systems of gamma-ray irradiated peas

open access: yesAgricultural and Food Science, 1967
Dormant seeds of a green pea variety Rondo were irradiated with 7000 rads of gamma rays from Co60 source. The frequency of mitotic disturbances in root tip cells was analysed during the first three weeks of growth. In agreement with earlier works a rapid
E. I. Kivi, J. T. H. Barkman
doaj  

Vestiges de chasse au Néolitique récent. La fosse de Vignely en bord de Marne

open access: yesArchéopages, 2010
Excavations in Vignely on an isolated cylindrical pit dating from the Late Neolithic have pro-duced numerous artefacts. The pit comprised five layers and was filled within a short period of time.
Paul Brunet   +5 more
doaj   +1 more source

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