Results 181 to 190 of about 770,455 (417)

Corrin Ring Modification in Peptide Drug Development – a Brief History of “Corrination”

open access: yesChemMedChem, EarlyView.
This review highlights the applications of vitamin B12 conjugation (“corrination”) to peptides in the field of peptide‐based therapeutics, focusing on improved physio‐chemical properties, targeted/localized drug delivery, and enhanced oral bioavailability.
Nancy Cham, Robert P. Doyle
wiley   +1 more source

GUMMA OF THE PITUITARY BODY [PDF]

open access: green, 1909
C. E. Wood
openalex   +1 more source

Residual Tumor Confers a 10-Fold Increased Risk of Regrowth in Clinically Nonfunctioning Pituitary Tumors. [PDF]

open access: yes, 2019
ObjectiveWe evaluated tumor recurrence and regrowth rates following endoscopic transnasal transsphenoidal (TNTS) surgical removal in a consecutive series of clinically nonfunctioning pituitary adenomas (CNFTs).DesignRetrospective chart review of clinical,
Bergsneider, Marvin   +10 more
core   +1 more source

Management of Acromegaly With Pasireotide LAR: A Case Study of Sustained Biochemical Control and Tumor Volume Reduction Without Worsening of Glycemia

open access: yesAACE Clinical Case Reports, 2016
: Objective: Pasireotide long-acting release (LAR), a next-generation, multireceptor-targeted somatostatin analogue with high binding affinity to somatostatin receptor type 5, has been shown to be superior to octreotide LAR in inducing biochemical ...
Kevin C.J. Yuen, MD, FRCP (UK)
doaj  

PitVQA: Image-grounded Text Embedding LLM for Visual Question Answering in Pituitary Surgery [PDF]

open access: yesarXiv
Visual Question Answering (VQA) within the surgical domain, utilizing Large Language Models (LLMs), offers a distinct opportunity to improve intra-operative decision-making and facilitate intuitive surgeon-AI interaction. However, the development of LLMs for surgical VQA is hindered by the scarcity of diverse and extensive datasets with complex ...
arxiv  

Inorganic Metal Nanoparticles in Reproductive Biology: Applications, Toxicities and Future Prospects

open access: yesChemPlusChem, EarlyView.
Metal nanoparticles (MNPs) have shown great promise in the livestock industry such as semen collection, nano‐purification, cryopreservation, sex sorting, bioimaging, drug and gene delivery. However, reproductive toxicity induced by MNP has adverse effects on various sexual functions including poor sperm parameters, testicular damage, ovary injury, and ...
Sangita Kundu   +3 more
wiley   +1 more source

A single-center prospective study evaluating the relationship of tumor consistency on remission in acromegaly patients

open access: yesScientific Reports
The nature of somatotroph adenomas has not been clearly revealed in studies. We consider that there are macroscopic differences in intraoperative tumor consistency in acromegaly patients.
Eren Yilmaz   +11 more
doaj   +1 more source

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