Results 11 to 20 of about 6,245 (175)

Higher blood pituitary adenylate cyclase‐activating polypeptide levels were causally associated with a decreased risk of Alzheimer's disease [PDF]

Alzheimers Dement
Abstract Background Previous studies in humans and animals have suggested that pituitary adenylate cyclase‐activating polypeptide (PACAP) is associated with Alzheimer's disease (AD) pathology. However, whether blood PACAP levels are causally linked to AD susceptibility remains largely unknown.
Guo X, Li R.
europepmc   +2 more sources

Differential Vulnerability of Oculomotor Versus Hypoglossal Nucleus During ALS: Involvement of PACAP

Frontiers in Neuroscience, 2020
Amyotrophic lateral sclerosis (ALS) is a progressive multifactorial disease characterized by the loss of motor neurons (MNs). Not all MNs undergo degeneration: neurons of the oculomotor nucleus, which regulate eye movements, are less vulnerable compared ...
Grazia Maugeri, Agata Grazia D’Amico, Giovanna Morello, Dora Reglodi, Sebastiano Cavallaro, Velia D’Agata   +5 more
doaj   +1 more source

Tracing the Origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP)

Frontiers in Neuroscience, 2020
Pituitary adenylate cyclase activating polypeptide (PACAP) is a well-conserved neuropeptide characteristic of vertebrates. This pluripotent hypothalamic neuropeptide regulates neurotransmitter release, intestinal motility, metabolism, cell division ...
João C. R. Cardoso, Manuel G. Garcia, Deborah M. Power   +2 more
doaj   +1 more source

Role of PACAP in Migraine Headaches

Pediatric Neurology Briefs, 2014
Investigators at Danish Headache Centre, University of Copenhagen, Glostrup, Denmark, studied the incidence of migraine during and after intravenous infusion of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal ...
J Gordon Millichap, John J Millichap
doaj   +1 more source

Pituitary adenylate cyclase-activating polypeptide (PACAP) in zebrafish models of nephrotic syndrome. [PDF]

PLoS ONE, 2017
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an inhibitor of megakaryopoiesis and platelet function. Recently, PACAP deficiency was observed in children with nephrotic syndrome (NS), associated with increased platelet count and ...
Benedicte Eneman, Mohamed A Elmonem, Lambertus P van den Heuvel, Laleh Khodaparast, Ladan Khodaparast, Chris van Geet, Kathleen Freson, Elena Levtchenko   +7 more
doaj   +1 more source

Markedly Reduced White Adipose Tissue and Increased Insulin Sensitivity in Adcyap1-Deficient Mice

Journal of Pharmacological Sciences, 2008
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide implicated in several metabolic functions, including insulin secretion and sympathoadrenal activation.
Shuhei Tomimoto, Tatsuya Ojika, Norihito Shintani, Hitoshi Hashimoto, Ken-ichi Hamagami, Kazuya Ikeda, Masanori Nakata, Toshihiko Yada, Yusuke Sakurai, Takeshi Shimada, Yoshiko Morita, Chie Ishida, Akemichi Baba   +12 more
doaj   +1 more source

Over-Expression of Pancreatic Pituitary Adenylate Cyclase–Activating Polypeptide (PACAP) Aggravates Cerulein-Induced Acute Pancreatitis in Mice

Journal of Pharmacological Sciences, 2009
.: Development of human chronic pancreatitis is associated with intrapancreatic accumulation of pituitary adenylate cyclase–activating polypeptide (PACAP) accompanied with an altered inflammatory response (Michalski et al., Am J Physiol Gastrointest ...
Ken-ichi Hamagami, Yusuke Sakurai, Norihito Shintani, Naoko Higuchi, Kazuya Ikeda, Hitoshi Hashimoto, Akinobu Suzuki, Hiroshi Kiyama, Akemichi Baba   +8 more
doaj   +1 more source

Pituitary adenylate cyclase-activating polypeptide ameliorates experimental acute ileitis and extra-intestinal sequelae. [PDF]

PLoS ONE, 2014
The neuropeptide Pituitary adenylate cyclase-activating polypeptide (PACAP) plays pivotal roles in immunity and inflammation. So far, potential immune-modulatory properties of PACAP have not been investigated in experimental ileitis.Mice were perorally ...
Markus M Heimesaat, Ildiko R Dunay, Silvia Schulze, André Fischer, Ursula Grundmann, Marie Alutis, Anja A Kühl, Andrea Tamas, Gabor Toth, Miklos P Dunay, Ulf B Göbel, Dora Reglodi, Stefan Bereswill   +12 more
doaj   +1 more source

Pituitary adenylate cyclase‐activating polypeptide inhibits cutaneous immune function [PDF]

European Journal of Immunology, 2003
AbstractEpidermal nerves are closely associated with Langerhans cells (LC) and may be able to release factors, such as calcitonin gene‐related peptide and epinephrine, that affect LC function. LC and the LC‐like cell line XS106 express mRNA for the pituitary adenylate cyclase‐activating polypeptide (PACAP) receptors VPAC1 and VPAC2. We examined whether
Sreedevi, Kodali, Ilyse, Friedman, Wanhong, Ding, Kristina, Seiffert, John A, Wagner, Richard D, Granstein   +5 more
openaire   +2 more sources

Pituitary adenylate cyclase activating polypeptide modulates catecholamine storage and exocytosis in PC12 cells. [PDF]

PLoS ONE, 2014
A number of efforts have been made to understand how pituitary adenylate cyclase activating polypeptide (PACAP) functions as a neurotrophic and neuroprotective factor in Parkinson's disease (PD).
Yan Dong, Gang Ning, Andrew G Ewing, Michael L Heien   +3 more
doaj   +1 more source