Results 21 to 30 of about 6,245 (175)

Pituitary adenylate cyclase activating polypeptide and migraine

Annals of Clinical and Translational Neurology, 2014
AbstractPituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood.
Zagami, AS, Edvinsson, L, Goadsby, PJ
openaire   +5 more sources

Role of pituitary adenylate cyclase‐activating polypeptide in modulating hypothalamic‐pituitary system

Reproductive Medicine and Biology, 2018
Background Pituitary adenylate cyclase‐activating polypeptide (PACAP) is a multifunctional peptide that is isolated and identified from the ovine hypothalamus, whose effects and mechanisms have been elucidated in numerous studies.
Aki Oride, Haruhiko Kanasaki, Satoru Kyo
doaj   +1 more source

Discovery of PACAP and its receptors in the brain

The Journal of Headache and Pain, 2018
Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularly high homology (~ 68%) to VIP.
Takahiro Hirabayashi, Tomoya Nakamachi, Seiji Shioda   +2 more
doaj   +1 more source

Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia [PDF]

Molecular Psychiatry, 2007
Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1: adenylate cyclase-activating polypeptide 1), a neuropeptide with neurotransmission modulating activity, is a promising schizophrenia candidate gene. Here, we provide evidence that genetic variants of the genes encoding PACAP and its receptor, PAC1, are associated with schizophrenia. We
R, Hashimoto, H, Hashimoto, N, Shintani, S, Chiba, S, Hattori, T, Okada, M, Nakajima, K, Tanaka, N, Kawagishi, K, Nemoto, T, Mori, T, Ohnishi, H, Noguchi, H, Hori, T, Suzuki, N, Iwata, N, Ozaki, T, Nakabayashi, O, Saitoh, A, Kosuga, M, Tatsumi, K, Kamijima, D R, Weinberger, H, Kunugi, A, Baba   +24 more
openaire   +2 more sources

Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors. [PDF]

PLoS ONE, 2011
Pituitary adenylate cyclase activating polypeptide (PACAP) is a member of the PACAP/glucagon family of peptide hormones, which controls many physiological functions in the immune, nervous, endocrine, and muscular systems.
Shiva Kumar, Augen Pioszak, Chenghai Zhang, Kunchithapadam Swaminathan, H Eric Xu   +4 more
doaj   +1 more source

Comprehensive behavioral analysis of pituitary adenylate cyclase-activating polypeptide (PACAP) knockout mice

Frontiers in Behavioral Neuroscience, 2012
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide acting as a neurotransmitter, neuromodulator, or neurotrophic factor. PACAP is widely expressed throughout the brain and exerts its functions through the PACAP-specific receptor
Satoko eHattori, Satoko eHattori, Keizo eTakao, Keizo eTakao, Koichi eTanda, Koichi eTanda, Keiko eToyama, Norihito eShintani, Akemichi eBaba, Akemichi eBaba, Hitoshi eHashimoto, Hitoshi eHashimoto, Hitoshi eHashimoto, Tsuyoshi eMiyakawa, Tsuyoshi eMiyakawa, Tsuyoshi eMiyakawa   +15 more
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Pituitary Adenylate Cyclase-Activating Polypeptide Protects Glomerular Podocytes from Inflammatory Injuries

Journal of Diabetes Research, 2015
Diabetic nephropathy (DN) is a leading cause of end-stage kidney disease; however, there are few treatment options. Inflammation plays a crucial role in the initiation and/or progression of DN.
Kenichi Sakamoto, Kyoko Kuno, Minoru Takemoto, Peng He, Takahiro Ishikawa, Shunichiro Onishi, Ryoichi Ishibashi, Emiko Okabe, Mayumi Shoji, Akiko Hattori, Masaya Yamaga, Kazuki Kobayashi, Harukiyo Kawamura, Hirotake Tokuyama, Yoshiro Maezawa, Koutaro Yokote   +15 more
doaj   +1 more source

Pituitary Adenylate-Cyclase Activating Polypeptide Regulates Hunger- and Palatability-Induced Binge Eating

Frontiers in Neuroscience, 2016
While pituitary adenylate cyclase activating polypeptide (PACAP) signaling in the hypothalamic ventromedial nuclei (VMN) has been shown to regulate feeding, a challenge in unmasking a role for this peptide in obesity is that excess feeding can involve ...
Matthew M. Hurley, Brian Maunze, Megan E. Block, Mogen M. Frenkel, Michael J. Reilly, Eugene Kim, Yao Chen, Yan Li, David A. Baker, Qing-Song Liu, SuJean Choi   +10 more
doaj   +1 more source

Genetic analysis and cAMP measurement: comparison between lean and obese anovulating mice [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2015
PURPOSE: To evaluate genes differentially expressed in ovaries from lean (wild type) and obese (ob/ob) female mice and cyclic AMP production in both groups.METHODS: The expression on messenger RNA levels of 84 genes concerning obesity was analyzed ...
Daniela Berguio Vidotti, Beatriz Schnabel, Mariane Secco, Priscila Cardoso Cristovam, Ricardo Carneiro Borra, Ismael Dale Cotrim Guerreiro da Silva   +5 more
doaj   +2 more sources

Antibacterial properties of the pituitary adenylate cyclase-activating polypeptide: A new human antimicrobial peptide. [PDF]

PLoS ONE, 2018
The Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), a polycationic, amphiphilic and helical neuropeptide, is well known for its neuroprotective actions and cell penetrating properties.
Somia Debbabi, Marie-Christine Groleau, Myriam Létourneau, Chitra Narayanan, Laura-Lee Gosselin, Mustapha Iddir, Jacinthe Gagnon, Nicolas Doucet, Eric Déziel, David Chatenet   +9 more
doaj   +1 more source