Results 31 to 40 of about 6,245 (175)

Novel Therapeutic Targets for Migraine

Biomedicines, 2023
Migraine, a primary headache disorder involving a dysfunctional trigeminal vascular system, remains a major debilitating neurological condition impacting many patients’ quality of life.
Areeba Nisar, Zubair Ahmed, Hsiangkuo Yuan   +2 more
doaj   +1 more source

Pituitary adenylate cyclase–activating polypeptide is reduced in Alzheimer disease [PDF]

Neurology, 2014
There is growing evidence that pituitary adenylate cyclase-activating polypeptide (PACAP) is associated with Alzheimer disease (AD) pathology in animal models, but human studies are needed.We studied the brains of patients with pathologically confirmed late-onset AD and age-matched cognitively normal (CN) subjects to investigate the expression of PACAP
Pengcheng, Han, Winnie, Liang, Leslie C, Baxter, Junxiang, Yin, Zhiwei, Tang, Thomas G, Beach, Richard J, Caselli, Eric M, Reiman, Jiong, Shi   +8 more
openaire   +2 more sources

ADCYAP1 (adenylate cyclase activating polypeptide 1 (pituitary)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2017
ADCYAP1 (adenylate cyclase activating polypeptide 1 (pituitary))
openaire   +2 more sources

Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: Cumulative mRNA Expression of PACAP and BDNF Genes Controlled by Calcium and cAMP Signals in Neurons

Journal of Pharmacological Sciences, 2005
Although it is widely accepted that an activity-dependent gene transcription is induced by the calcium (Ca2+) signals in neurons, it is still unclear how the particular mRNA moieties are transiently accumulated in response to synaptic transmission that ...
Mamoru Fukuchi, Akiko Tabuchi, Masaaki Tsuda   +2 more
doaj   +1 more source

From CGRP to PACAP, VIP, and Beyond: Unraveling the Next Chapters in Migraine Treatment

Cells, 2023
Migraine is a neurovascular disorder that can be debilitating for individuals and society. Current research focuses on finding effective analgesics and management strategies for migraines by targeting specific receptors and neuropeptides.
Masaru Tanaka, Ágnes Szabó, Tamás Körtési, Délia Szok, János Tajti, László Vécsei   +5 more
doaj   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Postulated Role of Vasoactive Neuropeptide-Related Immunopathology of the Blood Brain Barrier and Virchow-Robin Spaces in the Aetiology of Neurological-Related Conditions

Mediators of Inflammation, 2008
Vasoactive neuropeptides (VNs) such as pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) have critical roles as neurotransmitters, vasodilators including perfusion and hypoxia regulators, as well as immune
D. R. Staines, E. W. Brenu, S. Marshall-Gradisnik   +2 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

On the existence of possible pituitary adenylate cyclase-activating polypeptide adenylate type 1 receptor in earthworms [PDF]

Invertebrate Survival Journal, 2015
LETTER TO EDITOR (No Abstract)
L Molnár, E Pollák, I Somogyi, P Engelmann   +3 more
doaj   +2 more sources

Novel optimization of multi‐mechanistic approaches for the acute treatment of a migraine attack: A review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To highlight key factors required to optimize multi‐mechanistic approaches with oral combination treatments for the acute management of a migraine attack. Background Given the complex multi‐factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compared to monotherapies, but ...
Stephen Silberstein, Alan M. Rapoport
wiley   +1 more source