Results 51 to 60 of about 6,245 (175)
Frontiers in Neuroscience, 2019 Pituitary adenylate cyclase-activating polypeptide (PACAP1-38) is a highly conserved member of the secretin/glucagon/VIP family. The repressive effect of PACAP1-38 on the apoptotic machinery has been an area of active research conferring a significant ...
Robert Gábriel +3 more
doaj +1 more source
Neurons in a Dish: A Review of In Vitro Cell Models for Studying Neurogenesis
Journal of Neurochemistry, Volume 170, Issue 1, January 2026.Different in vitro cell models are valuable to study the different steps of neurogenesis, from the proliferation of neural stem and progenitor cells to the maturation of neurons. Pluripotent stem cells (including embryonic stem cells and induced pluripotent stem cells), immortalized human neuroblastoma cell lines (SH‐SY5Y, IMR‐32), and primary brain ...
Mariana Vassal +3 more
wiley +1 more source
Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.Abstract Cardiac fibrosis is characterized by an excessive accumulation of extracellular matrix proteins and occurs in a variety of cardiac diseases, such as the highly prevalent syndrome heart failure with preserved ejection fraction (HFpEF) and other cardiac disorders.
J. M. Schubart +11 more
wiley +1 more source
The Neuropeptide Pituitary Adenylate Cyclase–Activating Polypeptide and Islet Function [PDF]
Diabetes, 2001 The neuropeptide pituitary adenylate cyclase–activating polypeptide (PACAP) is ubiquitously distributed in both the central and peripheral nervous systems and exerts a variety of effects. PACAP is a neuropeptide in pancreatic islets, where it has been suggested as a parasympathetic and sensory neurotransmitter.
K, Filipsson, M, Kvist-Reimer, B, Ahrén
openaire +2 more sources
Acta Neurologica Scandinavica, Volume 2026, Issue 1, 2026.Background This study presents a comprehensive analysis of the trends and challenges in cluster headache research from 1936 to 2022, highlighting the increasing study trend and the significant contributions from the United States, Italy, and England.
Mohsen Hoseinnezhad +4 more
wiley +1 more source
Effect of Pituitary Adenylate Cyclase–Activating Polypeptide in Islet Transplantation [PDF]
Transplantation Proceedings, 2009 Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet substance serving as an intra-islet amplifier of glucose-induced insulin secretion similar to exendin-4. It has been reported that systemic administration of PACAP maintained beta-cell mass, delayed the onset of hyperglycemia, and protected beta cells from glucose toxicity. Moreover,
Y, Sakuma +10 more
openaire +2 more sources
生物医学转化Objective To investigate the neuroprotective effects and mechanisms of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Parkinson's Disease (PD) animal models.
Pei Lijuan +5 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2020 Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1) dysregulation has been associated with multiple stress-related psychopathologies that may be related to altered hippocampal function.
Gregory C. Johnson +3 more
doaj +1 more source
Pharmacoepidemiology and Drug Safety, Volume 34, Issue 12, December 2025.ABSTRACT Background Mounting evidence indicates that Type 2 diabetes mellitus (T2DM) is a public health challenge globally, and its occurrence is anticipated to surge in the forthcoming years. Dipeptidyl peptidase‐4 (DPP‐4) serves as a target for its treatment, with its inhibitors effectively preserving the levels of glucose‐dependent insulinotropic ...
Chinyere Aloke +4 more
wiley +1 more source
Small Science, Volume 5, Issue 12, December 2025.The authors propose a novel use for the conventional hypoglycemic drug, dipeptidyl peptidase IV (DPP4+) inhibitor sitagliptin. Sitagliptin prevents scar formation during wound healing through fibroblast‐to‐adipocyte conversion at least by preventing DPP4‐mediated truncation of IGF‐1.
Ju‐Lei Zhang +14 more
wiley +1 more source