Results 281 to 290 of about 811,244 (395)

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Polysomes of bovine anterior pituitary gland and their role in hormone and protein biosynthesis.

, 1968
P. R. Adiga, Robert O. Hussa, May C. Robertson, Hans R. Hohl, Theodore Winnick   +4 more
openalex   +1 more source

The intricate relationship between stress and animal welfare: from historical perspective to new avenues

Biological Reviews, EarlyView.
ABSTRACT We discuss the intricate relationship between the evolution of the concept of stress and the development of the concept of animal welfare. After a brief review of the main concepts of animal welfare, we analyse important steps in the evolution of the concept of stress, starting from the mechanistic approach of the General Adaptation Syndrome ...
Feifan Wu, Alan Tilbrook, Shane K. Maloney, Dominique Blache   +3 more
wiley   +1 more source

TWO METABOLICALLY ACTIVE PEPTIDES FROM PORCINE PITUITARY GLANDS

, 1961
E. B. Astwood, Richard J. Barrett, Henry G. Friesen   +2 more
openalex   +1 more source

GWAS Identifies SNPs Associated With Severe Adverse Events and Efficacy in Advanced Renal Cell Carcinoma Treated With Nivolumab

Cancer Science, EarlyView.
This study highlights the importance of germline genetic markers in predicting severe trAEs caused by nivolumab. Our findings support their potential to guide personalized immunotherapy and improve treatment safety and efficacy in advanced ccRCC and other cancers.
Tokiyoshi Tanegashima, Masaki Shiota, Shusuke Akamatsu, Hideaki Miyake, Masayuki Takahashi, Mototsugu Oya, Norihiko Tsuchiya, Naoya Masumori, Hideyasu Matsuyama, Wataru Obara, Nobuo Shinohara, Kiyohide Fujimoto, Masahiro Nozawa, Kojiro Ohba, Chikara Ohyama, Katsuyoshi Hashine, Tomomi Kamba, Koji Mita, Momokazu Gotoh, Shuichi Tatarano, Masato Fujisawa, Yoshihiko Tomita, Shoichiro Mukai, Keiichi Ito, Shoji Tokunaga, Masatoshi Eto, SNiP‐RCC investigators   +26 more
wiley   +1 more source

FOXO1 regulates expression of Neurod4 in the pituitary gland. [PDF]

Mol Cell Endocrinol
Stallings CE, Das P, Athul SW, Ukagwu AE, Jensik PJ, Ellsworth BS.   +5 more
europepmc   +1 more source

Granular-Cell Myoblastoma of the Pituitary Gland in an Old Rat: A Case Report

, 1968
G. J. V. Swaen, A E Becker
openalex   +1 more source

Reprimo (RPRM): A Tumor Suppressor That Induces Extrinsic Apoptosis via YAP Signaling

Cancer Science, EarlyView.
Reprimo (encoded by RPRM) is a p53 target gene that acts as a tumor suppressor and is frequently silenced by promoter hypermethylation in various cancers. Although previously known to function intracellularly as a tumor suppressor, recent studies revealed that secreted Reprimo also induces apoptosis in neighboring cells through a novel p53‐Reprimo ...
Masahiro Takikawa, Rieko Ohki
wiley   +1 more source

The 2022 WHO classification of tumors of the pituitary gland: An update on aggressive and metastatic pituitary neuroendocrine tumors. [PDF]

Brain Pathol
Casar-Borota O, Burman P, Lopes MB.
europepmc   +1 more source

Significance of Exogenous Estradiol on Plasma Cortisol and Salivary Cortisol During Adrenocorticotropic Hormone Stimulation in Women With Pituitary Insufficiency

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Oral estrogens increase the levels of cortisol binding globulin (CBG) potentially affecting test results for adrenal insufficiency. The objective was to evaluate the influence of oral and transdermal estradiol on total plasma (p) and salivary cortisol in hypogonadal women with secondary adrenal insufficiency or at risk of developing ...
Laura S. Aagaard, Jesper Krogh, Signe Perlman, Marianne Klose, Mikkel Andreassen   +4 more
wiley   +1 more source