Results 61 to 70 of about 884,861 (334)

Sexual Differentiation of Circadian Clock Function in the Adrenal Gland [PDF]

, 2016
Sex differences in glucocorticoid production are associated with increased responsiveness of the adrenal gland in females. However, the adrenal-intrinsic mechanisms that establish sexual dimorphic function remain ill defined. Glucocorticoid production is
Evans, Jennifer A., Gasser, Paul J, Klement, Claire, Kloehn, Ian, Officer, Laurel, Pillai, Savin B.   +5 more
core   +2 more sources

Single-cell transcriptomics identifies divergent developmental lineage trajectories during human pituitary development

Nature Communications, 2020
The anterior pituitary gland plays a central role in regulating various physiological processes, including body growth, reproduction, metabolism and stress response.
Shu Zhang, Yueli Cui, Xinyi Ma, Jun Yong, Liying Yan, Ming Yang, Jie Ren, Fuchou Tang, Lu Wen, J. Qiao   +9 more
semanticscholar   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Shell Neurons of the Master Circadian Clock Coordinate the Phase of Tissue Clocks Throughout the Brain and Body [PDF]

, 2015
Background: Daily rhythms in mammals are programmed by a master clock in the suprachiasmatic nucleus (SCN). The SCN contains two main compartments (shell and core), but the role of each region in system-level coordination remains ill defined.
Baba, Kenkichi, Baker, Kimberly M., Bartness, Timothy J., Callif, Ben L., Castanon-Cervantes, Oscar, Davidson, Alec J., Ehlen, J. Christopher, Evans, Jennifer A., Kloehn, Ian, Leise, Tanya, Mitchell, Andrew S., Paul, Ketema N., Suen, Ting-Chung, Teubner, Brett J.W., Tosini, Gianluca   +14 more
core   +2 more sources

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

Ectopic pituitary adenoma: The lost track of ciurea or the right man at wrong place

Interdisciplinary Neurosurgery, 2020
The aberrant development of pituitary gland may leave functioning or nonfunctioning tissues anywhere along the craniopharyngeal canal. Ectopic pituitary adenoma is extremely rare with a reported incidence of only 0.5% in the literature.
Suyash Singh, Gagandeep Attri, Kuntal Kanti Das, Sushila Jaiswal, Awadhesh Kumar Jaiswal   +4 more
doaj   +1 more source

Prolactin is a strong candidate for the regulation of luteal steroidogenesis in vizcachas (Lagostomus maximus) [PDF]

, 2018
Prolactin (PRL) is essential for the maintenance of the corpora lutea and the production of progesterone (P4) during gestation of mice and rats, which makes it a key factor for their successful reproduction.
Charif, Santiago Elías, Corso, María Clara, Cortasa, Santiago Andrés, Di Giorgio, Noelia Paula, Dorfman, Verónica Berta, Halperin, Julia, Inserra, Pablo Ignacio Felipe, Lux Lantos, V., Proietto, Sofia, Schmidt, Alan Raul, Vitullo, Alfredo Daniel   +10 more
core   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Regulation of Prolactin Release at the End Stage of Chicken Embryogenesis

The Journal of Poultry Science, 2022
Difference of onset of increase of PRL content in the anterior pituitary gland and plasma PRL concentration during the late stage of chicken embryogenesis is well known. To investigate the disagreement, changes in PRL content and PRL mRNA levels, and the
Norio Kansaku, Shin Wakui, Tomohiro Sasanami, Takeshi Ohkubo   +3 more
doaj   +1 more source

Acromegaly: pathogenesis & treatment [PDF]

, 2019
Acromegaly is a multi-system disorder whose etiology is most often traced back to a growth hormone-secreting pituitary adenoma (PA). Growth hormone (GH) secretion promotes insulin-like growth factor 1 (IGF-1) release from peripheral tissues, leading to ...
Tilvawala, Megha
core