Results 151 to 160 of about 248,144 (357)
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
Modulation of Pituitary Luteinizing Hormone Releasing Hormone Receptors by Sex Steroids and Luteinizing Hormone Releasing Hormone in the Rat [PDF]
MARCHETTI, Bianca Maria +3 more
openaire +3 more sources
Opioids in breast cancer: Between analgesia and modulation of tumour progression
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun +2 more
wiley +1 more source
Homo sapiens, industrialisation and the environmental mismatch hypothesis
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley +1 more source
ABSTRACT Introduction Over 10 million thyroid function tests (TFTs) are carried out in England each year, most requests coming from primary care. Our previous work showed that only 25% of results for patients being treated with Levothyroxine fell within the TSH/FT4 boundary circumscribing 75% of untreated individuals.
Adrian H. Heald +8 more
wiley +1 more source
Possible Involvement of Hypothalamic Dysfunction in Long COVID Patients Characterized by Delayed Response to Gonadotropin-Releasing Hormone. [PDF]
Otsuka Y +14 more
europepmc +1 more source
University Exams and Psychosocial Stress: Effects on Cortisol Rhythmicity in Students
ABSTRACT Background University exams are recognised as naturalistic stressors that may elicit psychosocial and physiological responses in students. This pilot study investigated the short‐ and long‐term effects of exam‐related stress on hypothalamic–pituitary–adrenal (HPA) axis activity, focusing on cortisol production and rhythmicity.
Filipy Borghi +6 more
wiley +1 more source
Automated competitive protein binding analysis and radioimmunoassay of serum cortisol without prior organic solvent extraction [PDF]
Braun, J. +2 more
core +1 more source

