Results 131 to 140 of about 741,920 (302)

GHRH-stimulated pituitary small extracellular vesicles inhibit hepatocyte proliferation and IGF-1 expression by its cargo miR-375-3p

Journal of Nanobiotechnology
Small extracellular vesicles (sEV) have emerged as a novel mode of intercellular material transport and information transmission. It has been suggested hormones may regulate the production and function of sEV.
Jiali Xiong, Yuxuan Wang, Hailong Wang, Junyi Luo, Ting Chen, Jiajie Sun, Qianyun Xi, Yongliang Zhang   +7 more
doaj   +1 more source

Bringing the Lab to the Field: Exploring Water‐Borne Corticosterone as a Physiological Indicator in Captive and Wild Common Frog Larvae (Rana temporaria)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Assessing physiological condition in wild populations is important for understanding how environmental variation shapes organismal performance. Water‐borne corticosterone (WB‐CORT) sampling shows promise for studying amphibian stress physiology, but its ecological relevance and limitations require evaluation, particularly when methods ...
Fabian Bartels, Katharina Ruthsatz
wiley   +1 more source

Sex‐Specific Early Life Corticosterone Stress‐Coping Capacity Is Linked to Mitochondrial Content and Telomere Maintenance

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Glucocorticoids are upregulated during acute challenges, contributing to maintenance of energy balance. However, if this upregulation exceeds a threshold or becomes chronic, it can lead to harmful effects. Investigating the factors behind between‐individual variation in the magnitude of the response to acute stress and how effectively ...
Mauricio Guillen‐Parra, Alberto Velando, Bibiana Montoya, Roxana Torres   +3 more
wiley   +1 more source

The hypothalamic effects of PACAP on the hypothalamic-pituitary-gonadal axis in male mice

Frontiers in Endocrinology
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a member of the vasoactive intestinal peptide (VIP) neuropeptide family and plays a role in the regulation of several releasing hormones and tropic hormones. The hypothalamic-pituitary-gonadal
Péter Faludi, Klaudia Barabás, Ferenc Lengyel, Ildikó Udvarácz, Dániel Pham, Olivér Kisjós, Zsuzsanna Nagy, Dóra Reglődi, Gergely Kovács   +8 more
doaj   +1 more source

Personalized multimodal physiological modeling of menstrual cycle dynamics using endocrine, metabolic and wearable signals

Journal of Intelligent Medicine, EarlyView.
Abstract Menstrual cycle tracking remains challenged by the limited physiological scope and inconsistent generalizability of existing wearable‐based approaches, which often rely on individual sensing modalities that incompletely capture the complexity of menstrual physiology.
Ejay Nsugbe, Georgianna Lin
wiley   +1 more source

Hypothalamic LH-Releasing Hormone: Chemistry, Physiology and Effect in Humans

, 1970
There is now good evidence that the secretion of LH and FSH from the anterior pituitary gland is controlled principally by the central nervous system and a feedback system, involving sex steroids [1, 2].
Y. Baba, Schally, Andrew V., J. J. Reeves, W. F. White, Aj, Kastin, A. J. Kastin, Bowers, C. Y., White, W. F., Reeves, J. J., C. Y. Bowers, A. Arimura, Baba, Y., Arimura, A., A. V. Schally   +13 more
core   +1 more source

When the Number Matters: Contextualising Australian Reference Values for 99ᵐTc‐Pertechnetate Thyroid Uptake

Journal of Medical Radiation Sciences, EarlyView.
Are the historical 1%–4% thyroid uptake reference values still valid in modern practice? This editorial examines why contemporary Australian and international data suggest otherwise and situates the new reference range reported by Wornes (https://doi.org/10.1002/jmrs.70078) and colleagues within the broader international literature.
Geoffrey Schembri, Jeremy Hoang
wiley   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Incretin‐Based Therapies: A Testable Hypothesis Linking Incretin Signaling, Mitochondrial Redox, and OXPHOS Efficiency

Obesity, EarlyView.
ABSTRACT Objective Incretin‐based obesity therapies (IBTs), especially GLP‐1 receptor agonists (GLP‐1 RAs), effectively treat obesity and improve comorbidities. However, their impact on energy metabolism is unclear. A recent case of acute generalized muscle weakness in a patient with mitochondrial myopathy after tirzepatide exposure raises concerns ...
Bryn Falahee, Caroline M. Apovian, Nawfal Istfan   +2 more
wiley   +1 more source

Association of Depression and Anxiety With Postoperative Complications After Septoplasty With Turbinoplasty

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objectives Evaluate the association between comorbid depression and anxiety and postoperative complications following septoplasty with turbinoplasty, and assess whether treatment of these conditions influences surgical outcomes. Study Design Retrospective cohort study with propensity‐score matched analysis. Setting Multi‐institutional database
Amala Nayak, Iman Adibi, Suhas Rao Velichala, Michael F. Armstrong, Theodore Schuman   +4 more
wiley   +1 more source