Results 1 to 10 of about 6,216 (180)
Animals, 2022 The release of reproductive hormones in the hypothalamic–pituitary–gonadal (HPG) axis is regulated by its upstream regulator, kisspeptin, and influenced by external stresses, including heat stress.
Hwan-Deuk Kim +9 more
doaj +1 more source
Pacemaking kisspeptin neurons [PDF]
Experimental Physiology, 2013 New findings What is the topic for this review?This review focuses on analysis of the electrophysiological properties of hypothalamic kisspeptin neurons. What advances does it highlight?Molecular and cellular electrophysiological analysis of kisspeptin neurons reveals that they express the critical pacemaker channels for generating burst‐firing ...
Martin J, Kelly +3 more
openaire +2 more sources
Hypothalamic KiSS1/GPR54 Gene Expressions and Luteinizing Hormone Plasma Secretion in Morphine Treated Male Rats [PDF]
International Journal of Fertility and Sterility, 2018 Background: The inhibitory effects of morphine and the stimulatory influence of kisspeptin signaling have been demonstrated on gonadotropin releasing hormone (GnRH)/luteinizing hormone (LH) release.
Homayoun Khazali +2 more
doaj +1 more source
Kisspeptin and Puberty in Mammals [PDF]
, 2013 Since the discovery of the G-protein coupled receptor 54 (kisspeptin receptor) and its ligand, kisspeptin, our understanding of the neurobiological mechanisms that govern the pituitary-gonadal axis has evolved dramatically. In this chapter, we have reviewed progress regarding the relationship between kisspeptin and puberty, and have proposed a novel ...
Ei, Terasawa +2 more
openaire +2 more sources
Regulation and Possible Functions of Kisspeptin in the Medial Amygdala
Frontiers in Endocrinology, 2017 Kisspeptin, encoded by the Kiss1 gene, is required for reproduction. Humans and mice lacking kisspeptin or its receptor, Kiss1r, have impairments in reproductive physiology and fertility.
Shannon B. Z. Stephens +1 more
doaj +1 more source
Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation [PDF]
Human Reproduction Update, 2018 Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regulators of the mammalian reproductive axis. Accumulating evidence has shown that kisspeptin is able to control both the pulsatile and surge GnRH release, playing fundamental roles in female reproduction, which include ...
Kai-Lun Hu +5 more
openaire +2 more sources
Kisspeptin and Clinical Disorders [PDF]
, 2013 The hypothalamic hormone GnRH has traditionally been viewed as a central driver of the hypothalamic-pituitary-gonadal axis. Pulsatile GnRH release is required for pulsatile gonadotropin secretion, which then modulates gonadal steroid feedback and brings about full fertility in the adult.
Letícia Gontijo, Silveira +2 more
openaire +2 more sources
Seasonal Variation in the Gonadotropin-Releasing Hormone Response to Kisspeptin in Sheep: Possible Kisspeptin Regulation of the Kisspeptin Receptor [PDF]
Neuroendocrinology, 2012 Kisspeptin signaling in the hypothalamus appears critical for the onset of puberty and driving the reproductive axis. In sheep, reproduction is seasonal, being activated by short days and inhibited by long days. During the non-breeding (anestrous) season, gonadotropin-releasing hormone (GnRH) and gonadotropin secretion is reduced, as is the expression ...
Qun, Li +3 more
openaire +2 more sources
Frontiers in Neuroendocrinology, 2022 Kisspeptin, encoded by the KISS1 gene, was first discovered as a potential metastasis suppressor gene. The prepro-kisspeptin precursor is cleaved into shorter mature bioactive peptides of varying sizes that bind to the G protein-coupled receptor GPR54 (=KISS1R).
Mageswary Sivalingam, Ishwar S. Parhar
openaire +2 more sources
International Journal of Endocrinology, 2020 Objective. Kisspeptin, a puberty control neuropeptide, has been discovered to have an additional role in metabolism and glucose homeostasis regulation.
Kochakorn Sithinamsuwan +6 more
doaj +1 more source