Kisspeptin-mediated improvement of sensitivity to BRAF inhibitors in vemurafenib-resistant melanoma cells [PDF]
Frontiers in Oncology, 2023 Metastatic dissemination is still one of the major causes of death of melanoma’s patients. KiSS1 is a metastasis suppressor originally identified in melanoma cells, known to play an important physiological role in mammals’ development and puberty. It has
Carlotta Guzzetti +7 more
doaj +2 more sources
Functional examination of novel kisspeptin phosphinic peptides. [PDF]
PLoS ONE, 2018 Kisspeptins acting on their cognate G protein-coupled receptor, kisspeptin receptor, play important roles in the suppression of cancer cell metastasis and regulation of the reproductive system, and therefore are important for therapeutic intervention ...
Xiaoyang Zhang +6 more
doaj +6 more sources
Sex-specific association between urinary kisspeptin and pubertal development [PDF]
Endocrine Connections, 2022 Kisspeptins play a crucial role during pubertal development, but little is known about how their peripheral concentrations relate to sexual maturation.
Rafaella Sales de Freitas +2 more
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Intratesticular signals regulate germ cell progression and production of qualitatively mature spermatozoa in vertebrates [PDF]
Frontiers in Endocrinology, 2014 Spermatogenesis, a highly conserved process in vertebrates, is mainly under the hypothalamic-pituitary control, being regulated by the secretion of pituitary gonadotropins, FSH and LH, in response to stimulation exerted by Gonadotropin Releasing Hormone (
Rosaria eMeccariello +6 more
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Kisspeptin Is Upregulated at the Maternal-Fetal Interface of the Preeclamptic-like BPH/5 Mouse and Normalized after Synchronization of Sex Steroid Hormones [PDF]
Reproductive Medicine, 2022 Insufficient invasion of conceptus-derived trophoblast cells in the maternal decidua is a key event in the development of early-onset preeclampsia (PE), a subtype of PE associated with high maternal and fetal morbidity and mortality.
Viviane C. L. Gomes +9 more
doaj +2 more sources
Increased expression of kisspeptin and GnRH forms in the brain of scombroid fish during final ovarian maturation and ovulation [PDF]
Reproductive Biology and Endocrinology, 2012 Background Kisspeptins (Kiss) are prime players in the control of reproductive function through their regulation of gonadotropin-releasing hormone (GnRH) expression in the brain.
Selvaraj Sethu +7 more
doaj +2 more sources
The Expression of Kisspeptins and Matrix Metalloproteinases in Extragenital Endometriosis [PDF]
BiomedicinesEndometriosis is characterized by a condition where endometrial tissue grows outside the uterine cavity. The mechanisms of endometrium growth during endometriosis might be similar to the development of a tumor.
Tatiana Kleimenova +5 more
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The role of neonatal kisspeptin in long-term social behavior in mammals [PDF]
Communications BiologyKisspeptins (Kiss) are key regulators of the hypothalamic-pituitary-gonadal axis, influencing testosterone surges essential for brain masculinization and behavioral development in mammals.
João R. Neves +2 more
doaj +2 more sources
Effect of Pre-Incubation of Cryopreserved Sperm with either Kisspeptin or Glutathione to Mitigate Freeze-Thaw Damage [PDF]
Iranian Journal of Medical Sciences, 2023 Background: Sperm cryopreservation reduces sperm quality. Kisspeptin (KP) has beneficial effects on sperm functions. This study compares the effect of KP and Glutathione (GSH) on mitigating the detrimental effects of the freeze-thaw cycle on sperm ...
Tayebeh Kermani +3 more
doaj +1 more source
Effect of Vitex agnus-castus ethanolic extract on hypothalamic KISS-1 gene expression in a rat model of polycystic ovary syndrome [PDF]
Avicenna Journal of Phytomedicine, 2021 Objective: Polycystic ovary syndrome (PCOS) is an endocrine system disruption that affects 6-10% of women. Some studies have reported the effect of Vitex agnus-castus (Vitagnus) on the hypothalamic-pituitary-gonad axis (HPG).
Zoleykha Feizollahi +4 more
doaj +1 more source