Kisspeptin-mediated improvement of sensitivity to BRAF inhibitors in vemurafenib-resistant melanoma cells [PDF]
Frontiers in Oncology, 2023 Metastatic dissemination is still one of the major causes of death of melanoma’s patients. KiSS1 is a metastasis suppressor originally identified in melanoma cells, known to play an important physiological role in mammals’ development and puberty. It has
Carlotta Guzzetti +7 more
doaj +2 more sources
Sex-specific association between urinary kisspeptin and pubertal development [PDF]
Endocrine Connections, 2022 Kisspeptins play a crucial role during pubertal development, but little is known about how their peripheral concentrations relate to sexual maturation.
Rafaella Sales de Freitas +2 more
doaj +2 more sources
Frontiers in Endocrinology, 2018 The European eel (Anguilla anguilla) presents a blockade of sexual maturation at a prepubertal stage due to a deficient production of gonadotropins.
Antonio Moreno-Herrera +2 more
exaly +3 more sources
Current Perspectives on Kisspeptins Role in Behaviour
Frontiers in Endocrinology, 2022 The neuropeptide kisspeptin is now well-established as the master regulator of the mammalian reproductive axis. Beyond the hypothalamus, kisspeptin and its cognate receptor are also extensively distributed in extra-hypothalamic brain regions.
Waljit Dhillo +2 more
exaly +3 more sources
The role of neonatal kisspeptin in long-term social behavior in mammals [PDF]
Communications BiologyKisspeptins (Kiss) are key regulators of the hypothalamic-pituitary-gonadal axis, influencing testosterone surges essential for brain masculinization and behavioral development in mammals.
João R. Neves +2 more
doaj +2 more sources
The Expression of Kisspeptins and Matrix Metalloproteinases in Extragenital Endometriosis [PDF]
BiomedicinesEndometriosis is characterized by a condition where endometrial tissue grows outside the uterine cavity. The mechanisms of endometrium growth during endometriosis might be similar to the development of a tumor.
Tatiana Kleimenova +5 more
doaj +2 more sources
Kisspeptins Regulating Fertility: Potential Future Therapeutic Approach in Infertility Treatment [PDF]
Journal of Clinical MedicineKonstantinos Nikolettos +2 more
exaly +2 more sources
Effect of Vitex agnus-castus ethanolic extract on hypothalamic KISS-1 gene expression in a rat model of polycystic ovary syndrome [PDF]
Avicenna Journal of Phytomedicine, 2021 Objective: Polycystic ovary syndrome (PCOS) is an endocrine system disruption that affects 6-10% of women. Some studies have reported the effect of Vitex agnus-castus (Vitagnus) on the hypothalamic-pituitary-gonad axis (HPG).
Zoleykha Feizollahi +4 more
doaj +1 more source
Effect of Pre-Incubation of Cryopreserved Sperm with either Kisspeptin or Glutathione to Mitigate Freeze-Thaw Damage [PDF]
Iranian Journal of Medical Sciences, 2023 Background: Sperm cryopreservation reduces sperm quality. Kisspeptin (KP) has beneficial effects on sperm functions. This study compares the effect of KP and Glutathione (GSH) on mitigating the detrimental effects of the freeze-thaw cycle on sperm ...
Tayebeh Kermani +3 more
doaj +1 more source
Serum kisspeptin levels mainly depend on ovarian expression of Kiss1 mRNA in female rats
Frontiers in Physiology, 2022 The hypothalamic kisspeptin/KISS1 receptor system is essential for puberty onset and reproductive development. Although serum kisspeptin might be associated with puberty, its levels, according to developmental stage, and its origin still remain unclear ...
Ahreum Kwon +7 more
doaj +1 more source