#363 : Kisspeptins and Human Reproduction: New Challenges in the Management of Couple Infertility
Fertility & Reproduction, 2023 Background and Aims: Human reproduction is strictly controlled by a complex neurohormonal system including the gonadotropin-releasing hormone (GnRH) production, which stimulates anterior pituitary gonadotropes secretion and thereby gonadal function. Now,
Afifa Sellami +5 more
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Expression of kisspeptins and kiss receptors suggests a large range of functions for kisspeptin systems in the brain of the European sea bass. [PDF]
PLoS ONE, 2013 This study, conducted in the brain of a perciform fish, the European sea bass, aimed at raising antibodies against the precursor of the kisspeptins in order to map the kiss systems and to correlate the expression of kisspeptins, kiss1 and kiss2, with ...
Sebastián Escobar +9 more
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Kisspeptin/Kisspeptin Receptor System in the Ovary [PDF]
Frontiers in Endocrinology, 2018 Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating ovulation in sexually mature females via the central control of the hypothalamic–pituitary–gonadal axis.
Kai-Lun Hu +4 more
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Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio). [PDF]
PLoS ONE, 2014 Kisspeptin1 (product of the Kiss1 gene) is the key neuropeptide that gates puberty and maintains fertility by regulating the gonadotropin-releasing hormone (GnRH) neuronal system in mammals.
Yali Zhao +4 more
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Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor Development
Frontiers in Endocrinology, 2018 KiSS-1 was first described as a metastasis suppressor gene in malignant melanoma. KiSS-1 encodes a 145 amino-acid residue peptide that is further processed, producing the 54 amino acid metastin and shorter peptides collectively named kisspeptins (KPs ...
Federica Fratangelo +3 more
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, 2010 In recent years, a substantial body of evidence has accumulated suggesting that the hypothalamic peptide hormone kisspeptin and its cognate receptor, G-protein-coupled receptor 54, play a fundamental role both as gatekeepers for the initiation of puberty and in the regulation of the hypothalamic-pituitary-gonadal axis.
Saira, Hameed, Waljit S, Dhillo
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Kisspeptins and RFRP-3 act in concert to synchronize rodent reproduction with seasons [PDF]
Frontiers in Neuroscience, 2013 Seasonal mammals use the photoperiodic variation in the nocturnal production of the pineal hormone melatonin to synchronize their reproductive activity with seasons. In rodents, the short day profile of melatonin secretion has long been proven to inhibit
Valerie eSimonneaux +3 more
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, 2008 The G-protein coupled receptor GPR54 has an essential role in the initiation and maintenance of mammalian fertility. Humans and mice with mutations in GPR54 have hypogonadotropic hypogonadism characterized by absence of sexual maturation and low levels of gonadotropic hormones (LH and FSH).
W. H. Colledge
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Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography-High-Resolution Mass Spectrometry for Doping Control Purposes. [PDF]
Drug Test AnalSensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Krombholz S +3 more
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Sexual Dimorphism in Kisspeptin Signaling
Cells, 2022 Kisspeptin (KP) and kisspeptin receptor (KPR) are essential for the onset of puberty, development of gonads, and maintenance of gonadal function in both males and females.
Eun Bee Lee +6 more
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