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Kisspeptin and fertility [PDF]
Journal of Endocrinology, 2010 The kisspeptins are a family of peptide hormones, which in recent years have been shown to play a critical role in the regulation of the hypothalamic-pituitary-gonadal axis, thus in turn influencing fertility and reproduction. This review examines the physiological role of kisspeptin and the kisspeptin receptor in the control of gonadotrophin and ...
Saira, Hameed +2 more
openaire +2 more sources
#363 : Kisspeptins and Human Reproduction: New Challenges in the Management of Couple Infertility
Fertility & Reproduction, 2023 Background and Aims: Human reproduction is strictly controlled by a complex neurohormonal system including the gonadotropin-releasing hormone (GnRH) production, which stimulates anterior pituitary gonadotropes secretion and thereby gonadal function. Now,
Afifa Sellami +5 more
doaj +1 more source
Expression of kisspeptins and kiss receptors suggests a large range of functions for kisspeptin systems in the brain of the European sea bass. [PDF]
PLoS ONE, 2013 This study, conducted in the brain of a perciform fish, the European sea bass, aimed at raising antibodies against the precursor of the kisspeptins in order to map the kiss systems and to correlate the expression of kisspeptins, kiss1 and kiss2, with ...
Sebastián Escobar +9 more
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MOLECULAR EVOLUTION OF GPCRS: Kisspeptin/kisspeptin receptors [PDF]
Journal of Molecular Endocrinology, 2014 Following the discovery of kisspeptin (Kiss) and its receptor (GPR54 or KissR) in mammals, phylogenetic studies revealed up to three Kiss and four KissR paralogous genes in other vertebrates. The multiplicity of Kiss and KissR types in vertebrates probably originated from the two rounds of whole-genome duplication (1R and 2R) that occurred in early ...
Pasquier, Jérémy +5 more
openaire +4 more sources
Inotropic action of the puberty hormone kisspeptin in rat, mouse and human: cardiovascular distribution and characteristics of the kisspeptin receptor. [PDF]
PLoS ONE, 2011 Kisspeptins, the ligands of the kisspeptin receptor known for its roles in reproduction and cancer, are also vasoconstrictor peptides in atherosclerosis-prone human aorta and coronary artery.
Janet J Maguire +6 more
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BMC Biology, 2022 Background Kisspeptins are neuropeptides that regulate reproductive maturation in mammals via G-protein-coupled receptor-mediated stimulation of gonadotropin-releasing hormone secretion from the hypothalamus.
Nayeli Escudero Castelán +10 more
doaj +1 more source
Current Perspectives on Kisspeptins Role in Behaviour
Frontiers in Endocrinology, 2022 The neuropeptide kisspeptin is now well-established as the master regulator of the mammalian reproductive axis. Beyond the hypothalamus, kisspeptin and its cognate receptor are also extensively distributed in extra-hypothalamic brain regions.
Edouard G. Mills +6 more
doaj +1 more source
Frontiers in Neuroscience, 2018 Genetic manipulation of teleost endocrine systems started with transgenic overexpression of pituitary growth hormone. Such strategies enhance growth and reduce fertility, but the fish still breed.
Vance L. Trudeau
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Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing. [PDF]
PLoS ONE, 2014 KISS1 is a broadly functional secreted proprotein that is then processed into small peptides, termed kisspeptins (KP). Since sequence analysis showed cleavage at KR or RR dibasic sites of the nascent protein, it was hypothesized that enzyme(s) belonging ...
Sitaram Harihar +4 more
doaj +1 more source
The evolution and variety of RFamide-type neuropeptides: insights from deuterostomian invertebrates [PDF]
, 2014 Five families of neuropeptides that have a C-terminal RFamide motif have been identified in vertebrates: (1) gonadotropin-inhibitory hormone (GnIH), (2) neuropeptide FF (NPFF), (3) pyroglutamylated RFamide peptide (QRFP), (4) prolactin-releasing peptide (
Elphick, MR, Mirabeau, O
core +1 more source