Functional studies of kisspeptin analogues and the human kisspeptin receptor [PDF]
, 2023 Kisspeptins and their cognate receptor, the kisspeptin receptor, play pivotal roles in the regulation of the development of puberty and cancer metastasis. However, the signalling pathways activated by kisspeptins and the kisspeptin receptor remain largely to be demonstrated.
Zhang, X
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Kisspeptins and RFRP-3 act in concert to synchronize rodent reproduction with seasons [PDF]
Frontiers in Neuroscience, 2013 Seasonal mammals use the photoperiodic variation in the nocturnal production of the pineal hormone melatonin to synchronize their reproductive activity with seasons. In rodents, the short day profile of melatonin secretion has long been proven to inhibit
Valerie eSimonneaux +3 more
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There is Kisspeptin – And Then There is Kisspeptin [PDF]
Trends in Endocrinology & Metabolism, 2015 While kisspeptin was initially found to function as a metastasis suppressor, after identification of its receptor KISS1R and their expression profiles in tissues such as the hypothalamus and adrenals, kisspeptin and KISS1R were predominantly assigned endocrine functions, including regulating puberty and fertility through their actions on hypothalamic ...
Mehboob A, Hussain +2 more
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Kisspeptin and fertility [PDF]
Journal of Endocrinology, 2010 The kisspeptins are a family of peptide hormones, which in recent years have been shown to play a critical role in the regulation of the hypothalamic-pituitary-gonadal axis, thus in turn influencing fertility and reproduction. This review examines the physiological role of kisspeptin and the kisspeptin receptor in the control of gonadotrophin and ...
Saira, Hameed +2 more
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Kisspeptins and the neuroendocrine control of reproduction: Recent progress and new frontiers in kisspeptin research [PDF]
, 2021 In late 2003, a major breakthrough in our understanding of the mechanisms that govern reproduction occurred with the identification of the reproductive roles of kisspeptins, encoded by the Kiss1 gene, and their receptor, Gpr54 (aka, Kiss1R).
Avendaño, S. +11 more
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Functional examination of novel kisspeptin phosphinic peptides. [PDF]
PLoS ONE, 2018 Kisspeptins acting on their cognate G protein-coupled receptor, kisspeptin receptor, play important roles in the suppression of cancer cell metastasis and regulation of the reproductive system, and therefore are important for therapeutic intervention ...
Xiaoyang Zhang +6 more
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Functional interactions between anteroventral periventricular kisspeptin neurons and gonadotropin-releasing hormone neurons in female mice. [PDF]
J NeuroendocrinolAbstract Kisspeptin neurons in the rostral hypothalamus are hypothesized to initiate preovulatory gonadotropin‐releasing hormone (GnRH) surges by causing estradiol‐dependent activation of GnRH neuron action potential firing and subsequent GnRH release.
Starrett JR +4 more
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Dissecting the KNDy hypothesis: KNDy neuron-derived kisspeptins are dispensable for puberty but essential for preserved female fertility and gonadotropin pulsatility [PDF]
, 2023 BACKGROUNDKiss1 neurons in the hypothalamic arcuate-nucleus (ARC) play key roles in the control of GnRH pulsatility and fertility. A fraction of ARC Kiss1 neurons, termed KNDy, co-express neurokinin B (NKB; encoded by Tac2).
Velasco Immaculada +19 more
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Arcuate kisspeptin neurons display two types of calcium events: Regulation by sex, gonads, and senktide. [PDF]
J NeuroendocrinolAbstract The pattern of gonadotropin‐releasing hormone (GnRH) release controls reproduction in vertebrates and is regulated by feedback from the gonads. Evidence is accumulating that steroid‐sensitive hypothalamic arcuate kisspeptin–neurokinin B–dynorphin (KNDy) neurons drive GnRH pulses.
DeFazio RA +4 more
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MOLECULAR EVOLUTION OF GPCRS: Kisspeptin/kisspeptin receptors [PDF]
Journal of Molecular Endocrinology, 2014 Following the discovery of kisspeptin (Kiss) and its receptor (GPR54 or KissR) in mammals, phylogenetic studies revealed up to three Kiss and four KissR paralogous genes in other vertebrates. The multiplicity of Kiss and KissR types in vertebrates probably originated from the two rounds of whole-genome duplication (1R and 2R) that ...
Pasquier, Jérémy +5 more
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