Kisspeptin and seasonality in sheep [PDF]
Peptides, 2009 Sheep are seasonal breeders, experiencing a period of reproductive quiescence during spring and early summer. During the non-breeding period, kisspeptin expression in the arcuate nucleus is markedly reduced. This strongly suggests that the mechanisms that control seasonal changes in reproductive function involve kisspeptin neurons.
Clarke, I.J. +4 more
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Frontiers in Physiology, 2023 Preeclampsia (PE) is a devastating hypertensive disorder of pregnancy closely linked to obesity. Long-term adverse outcomes may occur in offspring from preeclamptic pregnancies.
Viviane C. L. Gomes +8 more
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Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells [PDF]
, 2013 Reproduction is integrated by interaction of neural and hormonal signals converging on hypothalamic neurons for controlling gonadotropin-releasing hormone (GnRH).
Glidewell-Kenney, Christine +9 more
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KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion
European Journal of Histochemistry, 2011 KISS1 and its receptor, KISS1R, have both been found to be expressed in central nervous system, but few data are present in the literature about their distribution in peripheral nervous structures.
A. Porzionato +6 more
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Molecular Coevolution of Neuropeptides Gonadotropin-Releasing Hormone and Kisspeptin with their Cognate G Protein-Coupled Receptors [PDF]
, 2012 The neuropeptides gonadotropin-releasing hormone (GnRH) and kisspeptin (KiSS), and their receptors gonadotropin-releasing hormone receptor (GnRHR) and kisspeptin receptor (KiSSR) play key roles in vertebrate reproduction.
Dong-Kyu Kim +7 more
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Pacemaking kisspeptin neurons [PDF]
Experimental Physiology, 2013 New findings What is the topic for this review?This review focuses on analysis of the electrophysiological properties of hypothalamic kisspeptin neurons. What advances does it highlight?Molecular and cellular electrophysiological analysis of kisspeptin neurons reveals that they express the critical pacemaker channels for generating burst‐firing ...
Martin J, Kelly +3 more
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Kisspeptins inhibit human airway smooth muscle proliferation
JCI Insight, 2022 Sex and gender disparity in asthma is recognized and suggests a modulatory role for sex steroids, particularly estrogen. However, there is a dichotomous role for estrogen in airway remodeling, making it unclear whether sex hormones are protective or ...
Niyati A. Borkar +5 more
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Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio). [PDF]
PLoS ONE, 2014 Kisspeptin1 (product of the Kiss1 gene) is the key neuropeptide that gates puberty and maintains fertility by regulating the gonadotropin-releasing hormone (GnRH) neuronal system in mammals.
Yali Zhao +4 more
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Role of neurokinin B in the control of female puberty and Its modulation by metabolic status [PDF]
, 2012 [Abstract] Human genetic studies have revealed that neurokinin B (NKB) and its receptor, neurokinin-3 receptor (NK3R), are essential elements for normal reproduction; however, the precise role of NKB–NK3R signaling in the initiation of puberty remains ...
Castellano, Juan M. +12 more
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Kisspeptin: Beyond the Brain [PDF]
Endocrinology, 2015 The hypothalamic-based kisspeptin-signaling system is a major positive regulator of the neuroendocrine-reproductive axis in mammals. During the last decade, major advances have been made in understanding how this signaling system is regulated and how it can be manipulated clinically to achieve beneficial outcomes in treating sex steroid-dependent ...
Moshmi, Bhattacharya, Andy V, Babwah
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