Results 41 to 50 of about 1,992 (211)
Kisspeptin Signaling in the Brain [PDF]
Endocrine Reviews, 2009 Abstract Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged as key players in the regulation of reproduction. Mutations in humans or genetically targeted deletions in mice of either Kiss1 or Kiss1r cause profound hypogonadotropic hypogonadism.
Amy E, Oakley +2 more
openaire +2 more sources
Frontiers in Physiology, 2023 Preeclampsia (PE) is a devastating hypertensive disorder of pregnancy closely linked to obesity. Long-term adverse outcomes may occur in offspring from preeclamptic pregnancies.
Viviane C. L. Gomes +8 more
doaj +1 more source
KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion
European Journal of Histochemistry, 2011 KISS1 and its receptor, KISS1R, have both been found to be expressed in central nervous system, but few data are present in the literature about their distribution in peripheral nervous structures.
A. Porzionato +6 more
doaj +1 more source
Kisspeptins inhibit human airway smooth muscle proliferation
JCI Insight, 2022 Sex and gender disparity in asthma is recognized and suggests a modulatory role for sex steroids, particularly estrogen. However, there is a dichotomous role for estrogen in airway remodeling, making it unclear whether sex hormones are protective or ...
Niyati A. Borkar +5 more
doaj +1 more source
Kisspeptin: Beyond the Brain [PDF]
Endocrinology, 2015 The hypothalamic-based kisspeptin-signaling system is a major positive regulator of the neuroendocrine-reproductive axis in mammals. During the last decade, major advances have been made in understanding how this signaling system is regulated and how it can be manipulated clinically to achieve beneficial outcomes in treating sex steroid-dependent ...
Moshmi, Bhattacharya, Andy V, Babwah
openaire +2 more sources
Kisspeptin and seasonality in sheep [PDF]
Peptides, 2009 Sheep are seasonal breeders, experiencing a period of reproductive quiescence during spring and early summer. During the non-breeding period, kisspeptin expression in the arcuate nucleus is markedly reduced. This strongly suggests that the mechanisms that control seasonal changes in reproductive function involve kisspeptin neurons.
Clarke, I.J. +4 more
openaire +3 more sources
, 2022 Kisspeptins, a family of small peptides derived from the Kiss1 gene, have been described in trophoblast cell dynamics, placentation, and pregnancy outcomes.
Leite Gomes, Viviane Cristine
core +1 more source
Inhibitory effect of kisspeptins on insulin secretion from isolated mouse islets.
, 2009 Islet hormone secretion is regulated by a variety of factors, and many of these signal through G protein-coupled receptors (GPCRs). A novel islet GPCR is GPR54, which couples to the Gq isoform of G proteins, which in turn signal through the phospholipase
Vikman, Jenny, Ahrén, Bo
core +1 more source
Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders [PDF]
Endocrinology and Metabolism, 2015 Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of gonadotrophin releasing hormone (GnRH). Loss of kisspeptin signaling
Holly Clarke +2 more
doaj +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto +8 more
wiley +1 more source