Results 61 to 70 of about 2,088 (213)

Kisspeptins: Bridging energy homeostasis and reproduction

, 2010
Body energy reserves and metabolic state are relevant modifiers of puberty onset and fertility; forms of metabolic stress ranging from persistent energy insufficiency to morbid obesity are frequently linked to reproductive disorders.
Manuel Tena-Sempere, Tena-Sempere, Manuel, Agnete H. Bentsen, Bentsen, Agnete H, Jens D. Mikkelsen, Mikkelsen, Jens D, Castellano, Juan M, Juan M. Castellano   +7 more
core   +1 more source

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, Volume 160, Issue 1, Page 7-23, 1 January 2027.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source

Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation [PDF]

Human Reproduction Update, 2018
Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regulators of the mammalian reproductive axis. Accumulating evidence has shown that kisspeptin is able to control both the pulsatile and surge GnRH release, playing fundamental roles in female reproduction, which include ...
Kai-Lun Hu, Hsun-Ming Chang, Hong-Cui Zhao, Yang Yu, Rong Li, Jie Qiao   +5 more
openaire   +2 more sources

Markers of Genetic Variation in Blue Gourami (Trichogaster trichopterus) as a Model for Labyrinth Fish

Biology, 2021
Markers of genetic variation between species are important for both applied and basic research. Here, various genes of the blue gourami (Trichogaster trichopterus, suborder Anabantoidei, a model labyrinth fish), many of them involved in growth and ...
Gad Degani, Isana Veksler-Lublinsky, Ari Meerson   +2 more
doaj   +1 more source

The Role of Kisspeptin in Sexual Behavior [PDF]

Seminars in Reproductive Medicine, 2019
AbstractSexual behavior is essential for the perpetuation of a species. In female rodents, mate preference and lordosis behavior depend heavily on the integration of olfactory cues into the neuroendocrine brain, yet its underlying neural circuits are not well understood.
Hellier, Vincent, Brock, Olivier, Bakker, Julie   +2 more
openaire   +4 more sources

The effect of ghrelin on Kiss-1 and KissR gene transcription and insulin secretion in rat islets of Langerhans and CRI-D2 cell line [PDF]

Iranian Journal of Basic Medical Sciences, 2017
Objective(s): Ghrelin is a peptide hormone that has been shown to have numerous central and peripheral effects. The central effects including GH secretion, food intake, and energy homeostasis are partly mediated by Kiss1- KissR signaling pathway. Ghrelin
Mandana Mahmoodzaeh Sagheb, Negar Azarpira, Mokhtar Mokhtary   +2 more
doaj   +1 more source

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Journal of Internal Medicine, Volume 300, Issue 5, Page 590-609, November 2026.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede   +5 more
wiley   +1 more source

Kisspeptin and Puberty in Mammals [PDF]

, 2013
Since the discovery of the G-protein coupled receptor 54 (kisspeptin receptor) and its ligand, kisspeptin, our understanding of the neurobiological mechanisms that govern the pituitary-gonadal axis has evolved dramatically. In this chapter, we have reviewed progress regarding the relationship between kisspeptin and puberty, and have proposed a novel ...
Ei, Terasawa, Kathryn A, Guerriero, Tony M, Plant   +2 more
openaire   +2 more sources

Design and synthesis of fluorescent probes for GPR54. [PDF]

, 2014
Kisspeptins are neuropeptides that induce the secretion of gonadotropin-releasing hormone via the activation of the cognate receptor, G-protein coupled receptor 54 (GPR54).
Uenoyama, Yoshihisa, Kaneda, Masato, Fujii, Nobutaka, Ohno, Hiroaki, Misu, Ryosuke, Maeda, Kei-ichiro, Ieda, Nahoko, Oishi, Shinya, Hirasawa, Akira, Tsukamura, Hiroko   +9 more
core   +1 more source

Intratesticular signals regulate germ cell progression and production of qualitatively mature spermatozoa in vertebrates

Frontiers in Endocrinology, 2014
Spermatogenesis, a highly conserved process in vertebrates, is mainly under the hypothalamic-pituitary control, being regulated by the secretion of pituitary gonadotropins, FSH and LH, in response to stimulation exerted by Gonadotropin Releasing Hormone (
Rosaria eMeccariello, Rosanna eChianese, Teresa eChioccarelli, Vincenza eCiaramella, Silvia eFasano, Riccardo ePierantoni, Gilda eCobellis   +6 more
doaj   +1 more source